ISSN:
1432-1041
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In nine subjects representing a majority (75 percent) of the population tested, ten milligrams of Dexoxadrol combined with 600 mg of acetylsalicylic acid (ASA) was essentially equivalent to 20 or 30 mg of Dexoxadrol pooled sample when tested by ischemic arm method, both doses being significantly more potent than ASA alone one hour after dosage. Three hours after dosage, all doses of Dexoxadrol were still significantly above ASA alone or lactose placebo indicating a more prolonged action of this drug. The stimulating effect of lactose placebo is postulated to explain the temporary rise (1 h) noted by use of this substance. When all twelve subjects are considered, because of three negative reactors, only statistically significant differences between ten milligrams of Dexoxadrol plus 600 mg of ASA are distinguishable from ASA alone or placebo at the end of one hour. At all dosage levels some side effects similar to alcohol were noted, numbness, dizziness, drowsiness, etc., as described by (LASAGNA and PEARSON, 1965). The 30 and 20 mg dosage produced more prominent psychic effects, while the 10 mg dosage with ASA produced a minimum of such effects and was virtually as effective as the higher dosage in nine of twelve subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00404660
