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The effect of nisin on murein synthesis (1980)

Reisinger, Peter ; Seidel, Heinz ; Tschesche, Harald ; [et al.]

Springer

Archives of microbiology 127 (1980), S. 187-193

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ISSN: 1432-072X

Keywords: Antibiotics ; Murein (peptidoglycan) synthesis ; Nisin

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract Nisin inhibits murein synthesis with concomitant accumulation of undecaprenyl-pyrophospho-MurNAc(pentapeptide) (lipid intermediate I). This inhibition is caused by the formation of a complex between the antibiotic and lipid intermediate I. Undecaprenyl-pyrophospho-MurNAc(pentapeptide)-GlcNAc (lipid intermediate II) also forms a complex with nisin. However, when murein synthesis is inhibited by nisin, this latter complex is not formed since lipid intermediate II is no longer synthesized.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00427192

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