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Bay K 8644 induce enhancement of K+ current in both single heart cell and smooth muscle cell (1989)

Renaud, J -F ; Bkaily, G. ; Benabderrazik, M. ; [et al.]

Springer

Molecular and cellular biochemistry 80 (1989), S. 73-78

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ISSN: 1573-4919

Keywords: heart cells ; smooth muscle Bay K 8644 ; K+ current ; patch clamp

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Summary The effects of the Ca2+ agonist Bay K 8644 on outward potassium currents have been studied in single ventricular cells of chick embryo and aortic single cells of rabbit using the whole-cell patch clamp technique. Bay K 8644 was found to increase lK in both heart and aortic single cells. This effect of Bay K 8644 on both muscle was reversed by Mn2+ and blocked by 20 mM TEA. The Bay K 8644 potassium I/V curve of single heart cell had a N shape, which is Ca2+ dependent. These data strongly suggest that Bay K 8644 increases a gK(ca) in both aortic and heart muscle.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00231005

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