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Phase II trial of piroxantrone in gastric carcinoma (1994)

Hantel, Alexander ; Tangen, Catherine ; Gluck, William L. ; [et al.]

Springer

Investigational new drugs 12 (1994), S. 159-161

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ISSN: 1573-0646

Keywords: piroxantrone ; gastric adenocarcinoma

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Twenty-one evaluable patients with advanced gastric adenocarcinoma were treated with piroxantrone at a dose of 150 mg/m2 intravenously every 21 days. One objective response was seen for an overall response rate of 5% (95% confidence interval 0–24%). Toxicities of grade ≥ 3 were primarily hematologie and seen in 13/21 patients. Piroxantrone has minimal activity against gastric adenocarcinoma and no further investigation of this agent on this schedule in this disease is recommended.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00874449

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