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Liposome/white-cell interactions in vivo (1983)

Norman Palmer, T. ; Warner, James P.

Springer

Bioscience reports 3 (1983), S. 479-485

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ISSN: 1573-4935

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract The purpose of this study was to establish whether liposomes administered via the intravenous route promote granulocyte aggregation and pulmonary leucostasis. White cells (labelled with [IIIln]tropolanate) and positively and negatively charged liposomes (containing entrapped [99mTc]DTPA) were administered i.v. to rats. The blood clearance and tissue distribution ofIIIIn label was not altered by the administration of liposomes (and vice versa) and it is inferred that on intravenous liposome administration liposome/white-cell interactions are unlikely to compromise lung function.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01121960

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