ISSN:
1573-4927
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract An abnormal human fetal hemoglobin not only may be either aGγ- or anAγ-chain variant but also may be present in a different proportion of the total fetal hemoglobin.Gγ-Chain variants contribute either about one-fourth or one-eighth to the total production of HbF in the heterozygote, whereas theAγ-chain variants approximate either one-eighth or one-sixteenth of the total HbF. These observations may indicate the presence of four nonallelic Hbγ structural genes (termed $$Hb_{_m^G \gamma } ,Hb_{_1^G \gamma } ,Hb_{_m^A \gamma } ,andHb_{_1^A \gamma } $$ ) which produce γ chains in an approximate ratio of 4 : 2 : 2 : 1. HbF Malta I is considered to be the product of a mutant of the $$Hb_{_m^G \gamma } $$ locus, an undefined HbFx that of the $$Hb_{_1^G \gamma }$$ locus, HbF Hull and HbF Jamaica products of mutated $$Hb_{_m^A \gamma }$$ loci, and the newly discovered HbF Malta II a mutant of the $$Hb_{_1^A \gamma }$$ gene.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00486084
