ISSN:
0887-624X
Schlagwort(e):
poly-γ-D-glutamic acid
;
biopolymer
;
covalent modification
;
Chemistry
;
Polymer and Materials Science
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Methods for the covalent modification in aqueous solution of poly-γ-D-glutamic acid from Bacillus licheniformis have been studied. Co-derivatization of a synthetic UV-absorbent amine and ethanolamine, using a water-soluble carbodi-imide coupling agent, yielded a water-soluble modified polymer. Derivatization of the polymer was accompanied by cleavage of the γ-linked polypeptide backbone, and a reduction in molecular mass from 170 to 10 kDa. A procedure was developed for the removal of noncovalently bound ligands by treatment with 5 M CaCl2. The polymer sidechains also reacted in aqueous solution with p-nitrophenyl acetate to form covalent linkages. © 1998 John Wiley & Sons, Inc. J. Polym. Sci. A Polym. Chem. 36: 1995-1999, 1998
Zusätzliches Material:
4 Ill.
Materialart:
Digitale Medien
