ISSN:
0360-6376
Keywords:
Physics
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
New polymeric cinchona alkaloids having favorable structures and properties for asymmetric catalysts have been prepared by radical copolymerization of the alkaloids with acrylonitrile using azobisisobutyronitrile (AIBN) as an initiator. Of the many reaction solvents tried, dimethylformamide (DMF) was found to be the solvent of choice especially for a large-scale synthesis. Alkaloid monomers employed were free dalkaloids, such as quinine, quinidine, cinchonidine, and cinchonine, and modified ones including 9-O-ethoxycarbonylquinine and quinine salts. The copolymers were thermally stable powders, soluble in DMF and DMSO, and insoluble in common organic solvents. They were found to be converted into water-soluble polymeric alkaloids by hydrolysis with alkaline hydrogen peroxide.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/pol.1980.170180120
