ISSN:
0018-019X
Schlagwort(e):
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
The mixed azines 4 and 5 were prepared by reaction of naloxazone (2) with either oxymorphone (6) or 14-O-methyloxymorphone (7) and tested in vitro using opioid receptor binding assays and in vivo using the AcOH-writhing test in mice. Compound 4 was found to be a partial agonist, while compound 5 was a potent opioid agonist with higher potency than morphine.
Zusätzliches Material:
2 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/hlca.19940770412