ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The fused pentacyclic alkaloid 2-bromoleptoclinidinone (1) isolated from an ascidian possesses a bidentate chelating site. Complexation of 1 with [cis-RuCl2{(D8)bpy}2] · 2H2O forms an octahedral complex which was isolated both as hexafluorophosphate 2 and chloride 3 salts. Intercalation of 3 in calf-thymus DNA was shown to occur as well as photoactivated cleavage of double-strand supercoiled DNA pBR322 under visible-light irradiation.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19910740711