ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Yeast reduction of rac-ethyl 2-methyl-6-oxocylohexanecarboxylate (rac-1) yielded selectively (+)-ethyl 2-hydroxy-6-methylcyclohexane carboxylate (+)-2 (Scheme 1) which has been alkylated with 5-iodo-2-methylbut-2-ene by (the dianion method to furnish the 4-methylbut-3-enyl derivat 3 (Scheme 3)). NaBH4 reduction of (+)-1 led to three hydroxy-carboxylates (-)-2, (+)-5, and (-)-6 (Scheme 4). Allylation of the dianion of (+)-5 afforded (+)-7.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19890720821