ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 8-substituted xanthines 1-21 (including compound S 9795), caffeine (22), and the three isomeric dimethyl-xanthines 23-25 (see Table 1), were examined for their lipophilic behaviour using a reversed-phase HPLC technique. A number of flexible compounds showed a smaller-than-expected lipophilicity which based on conformational and tautomeric calculations were ascribed to the predominance of folded forms. A QSAR analysis of the phosphodiesterase-inhibitory potency of several compounds showed favourable factors to be a low lipophilicity and the absence of a substituent on the N7 position.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19890720314