ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The distinction between derivatives of penicilloic acids with modified α-carboxyl function and the corresponding penicilloic acids themselves by means of a photometric test is described. The procedure involves conversion of the penicillin derivatives to penamaldates by the action of mercuric chloride, and comparison of the stability of the extinction at 282 nm in phosphate buffer at pH 7,4. The stabilities of the free penamaldates made from penicilloic acids are quite low (half life 4 to 5 minutes) and contrast with the high stabilities of penamaldoyl derivatives obtained from the α-derivatives of penicilloic acids. Some characteristics of the method are discussed, and its potential usefulness for the quantitative analysis of mixtures of penicilloic acid and α-derivatives of penicilloic acid is demonstrated.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19660490531
