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Über einige β-Dialkylaminobuttersäureamide mit anästhetischer Wirkung (1953)

Hofstetter, Emil ; Smith, A. E. Wilder

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 36 (1953), S. 1698-1705

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ISSN: 0018-019X

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The preparation of some β-alkylaminobutyric-acid-amides from the corresponding crotonic acid amides and dimethyl or diethylamine under pressure at 100-150° is described. Two diethylamino acetic acid amides were prepared by reacting N-benzyl-chloracetamide or N-(pethoxybenzyl)-chloracetamide with diethylamine. All these β-dialkyl-aminobutyric and dialkylaminoacetic acid amides show local anaesthetic activity. Two of them (β-diethylaminobutyric acid anilide and β-diethylamino-butyric acid-p-phenetidide) show promise as long acting anaesthetics of low toxicity for nerve block anaesthesia, and are under clinical investigation.

Additional Material: 3 Tab.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/hlca.19530360703

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