ISSN:
0009-2851
Schlagwort(e):
Chemistry
;
Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
In the last decade, major advances in the understanding of the biology of aging were made. Studies in worms, flies and yeast led to the identification of several life-extending genes. In mammals, two genes were found which, when mutated, shorten life span. Previous studies in rodents reporting life span prolongation by caloric restriction were confirmed and extended to lower organisms. The studies arc consistent with and supportive of the free radical theory of aging, which secs reactive oxygen species as the main contributor to aging. A refinement of this theory puts mitochondrial DNA into the center of the aging process. It appears that mitochondrial DNA may be both, a yardstick for the biological age and a signalling device to tell the organism when to die. A diet low in calories and high in antioxidants promises to lead to a better quality of life at old age and possibly to increased life span for humans.
Zusätzliches Material:
2 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/ciuz.19990330407
