Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Preparation and Reactions of N-Phenacyl-N-tosylhydroxylamines and -hydrazinesO-Alkyl-N-phenacyl-N-tosylhydroxylamines 3 were prepared in two steps from O-alkylhydroxylamines 1. In the presence of a base the N-tosylhydroxylamines 3 undergo rearrangement and cleavage to N-tosylphenacylamine (5) and aldehydes 6. N-Alkul-N′-phenacyl-N,N′-ditosylhydrazines 12 were obtained by stepwise treating of N,N′-ditosylhydrazine with alkyl halide and phenacyl bromide/potassium tert-butoxide/DMF.
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