ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Hits per page

hit 1 - 1 | 1 hit

Select All Export

Electronic Resource

Herstellung, optische Reinheit und Konfiguration der Flecainid-Enantiomeren (1985)

Blaschke, Gottfried ; Scheidemantel, Ursula ; Walther, Bernd

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 118 (1985), S. 4616-4619

add to mindlist on the mindlist

Details

ISSN: 0009-2940

Keywords: Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Preparation, Optical Purity and Configuration of the Enantiomers of FlecainideThe chiral antiarrhythmic drug flecainide (rac-1) was resolved by fractional crystallization of the diastereomeric salts with optically active mandelic acid. Derivatization with (+)-1-phenylethyl isocyanate and analytical separation of the diastereomers 3 by HPLC on silica gel confirmed the optical purity of the enantiomers. CD-Spectra of the N-chloro derivatives established the absolute configuration: (-)-1 is R-, (+)-1 S-configurated.

Additional Material: 1 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/cber.19851181132

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

hit 1 - 1 | 1 hit