ISSN:
0947-6539
Keywords:
biomimetic chemistry
;
EXAFS spectroscopy
;
ferritin
;
iron homeostasis
;
nanoparticles
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Structural models for the hydroxo(oxo)iron core of ferritin include extended mineral structures and cluster systems such as [Fe11O6(OH)6(O2CPh)15] ( = Fe11) and two clusters that crystallise in the same lattice (compound 1), namely, [Fe17(m̈3-O)4(m̈3-OH) 6(m̈2-OH)10(heidi)8(H2O)12]3+and[Fe19(m̈3-O)6(m̈3-OH)6(m̈2-OH)8(heidi)10(H2O)12]1+. The suitability of these systems as models for the structure of the core of ferritin has been tested by comparing their Fe K-edge EXAFS and X-ray crystallographic results with the Fe K-edge EXAFS data on horse spleen ferritin. The interpretative procedure for the EXAFS analysis was optimised by using the X-ray crystallographic data for compound 1 as a basis. This protocol was then used to interpret the Fe K-edge EXAFS spectra of α- and γ-Fe(O)OH and to reinterpret that previously recorded for horse spleen ferritin. The published Fe K-edge EXAFS data on Fe11 were also considered. The Fe⃛Fe distances provide a clear indication of the nature of the hydroxo(oxo)iron assembly. It was found that the iron-iron interactions are the most reliable guide. Clusters are shown to be more appropriate than infinite lattices as structural models for the core of ferritin.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.1460020604
