ISSN:
0947-3440
Keywords:
Carbohydrates
;
Saccharides
;
Glycosyltransferases
;
Trichloroacetimidates
;
Transferases
;
Enzymes
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Building Units of Oligosaccharides, CIX. - Synthesis of Modified Oligosaccharides of N-Glycoproteins for Substrate Specificity Studies of N-Acetylglucosaminyltransferase IA series of modified derivatives of the trisaccharide octyl α-D-Man(1→3)-[α-D-Man(1→6)]-β-D-Man were synthesized for substrate specificity studies of N-acetylglucosaminyltransferase I (GlcNAc-T I). The hydroxyl groups at C-3, C-4 and C-6 of the α(1→3)-linked Mannose were replaced by hydrogen and methoxy groups. At the α(1→6)-linked mannose the hydroxyl group at C-2 was deoxygenated and the hydroxyl groups at C-3, C-4 and C-6 were replaced by methoxy groups. The syntheses of the ten trisaccharides were carried out by the interchangeable combination of modified building blocks. The trichloroacetimidate method was favourable for all glycosylation steps.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199519950109