ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The role of the β-turns in the peptide interaction with several cations was investigated. In this work we report the solution studies of four linear peptides: Z-Aib-Aib-Aib-L-Val-OMe, Boc-D-alle-L-Ile-D-alle-L-Ile-OMe, Boc-L-Leu-L-Leu-L-Leu-L-Leu-OMe, and Boc-L-Phe-B-Phe-L-Phe-D-Phe-OMe.CD and 1H-nmr spectra reveal the presence of multiple ion-bounding equilibria. The stoichiometry and binding constant of the four peptide in the presence of Ca2+ ions in acetonitrile solution has been determined.Variable-temperature nmr spectra in the absence and in thepresence of a large excess of cation have shown that the complexation process is not critically dependent on the conformation of the peptide.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.360300119
