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Characterization of a membrane permeation system for controlled drug delivery studies (1985)

Tojo, K. ; Sun, Y. ; Ghannam, M. M. ; [et al.]

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 31 (1985), S. 741-746

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Hydrodynamic characteristics of an in vitro membrane permeation system for controlled drug delivery studies were investigated by measuring dissolution rates of benzoic acid in various aqueous solutions of polyethylene glycol 400. The mass transfer coefficient was well correlated in terms of three dimensionless numbers: Sherwood, Schmidt, and Reynolds numbers. By using the correlation equation, the intrinsic permeation rate of testosterone through silicone membranes was precisely extracted from the experimental data obtained under various nonideal flow conditions.

Additional Material: 8 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/aic.690310506

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