ISSN:
0001-1541
Keywords:
Chemistry
;
Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
A slow enzyme deactivation process taking place in parallel with the main enzymatic reaction in a continuous stirred-tank reactor can cause a departure from the optimal operating conditions, or, even a reactor failure. One way of minimizing productivity losses and maintaining optimal reactor conditions is by properly manipulating the flow rate of the reactor. The optimal flow-control policy for typical enzyme kinetics with parallel enzyme deactivation is derived. Both the complete and an approximate analytical solution are presented. The approximate solution, which is actually a quasisteady-state solution, is a very good approximation when the deactivation process is slow compared to the main enzymatic reaction and can be easily implemented as a feedback control based on the current state of the reactor. If the deactivation kinetics is the same as that of the main reaction and the cost of the reactant is negligible compared to that of the product, the quasisteady-state solution is indeed the exact solution.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aic.690290311
