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Application of cyclodextrins to chiral analysis by 1H NMR spectroscopy (1988)

Casy, A. F. ; Mercer, A. D.

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 26 (1988), S. 765-774

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ISSN: 0749-1581

Keywords: Inclusion comploxes ; Cyclodextrins ; Chiral antihistamines ; Chiral analgesics ; Chiral analysis ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The influence of inclusion complex formation between cyclodextrins (chiefly the β-polymer) and a variety of chiral antihistaminic and analgesic agents on the 1H NMR features of both guest and host partners is reported. In many cases equivalent protons of antipodes give resonances which differ in chemical shift after inclusion, and the potential value of the data to chiral analysis and to elucidation of the structures of the inclusion complexes is demonstrated.

Additional Material: 6 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/mrc.1260260908

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