ISSN:
0030-4921
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Nitrogen-14 nuclear quadrupole resonance (NQR) spectra of nicotinic acid derivatives, known as antitumor agents, are reported and analyzed in the framework of the Townes and Dailey theory. A strong correlation exists between the charge difference σNC - π at the pyridinic nitrogen and the inhibition of acetylcholinesterase by nicotinic acid derivatives, in which the inhibition potency (pI50) increases as the charge difference σNC - π increases. There are significant differences between 14N NQR spectra for the pyridinic nitrogen sites of nicotinic acid and nicotinamide; these can be explained in terms of the differences in hydrogen bond lengths.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1270150411