ISSN:
0030-4921
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Carbon-13 chemical shifts and 1J(CH) coupling constants of piperidine, 4-t-butylpiperidine, five C-methyl substituted piperidines and of the corresponding N-methyl compounds have been measured. These NMR parameters have also been determined for the fourteen corresponding hydrochlorides. The N-methyl-C-methyl piperidinium salts showed two stereoisomers on the positive nitrogen atom. The effect of protonation is discussed in relation to charge and steric effects and the methyl substituent effects are compared with those of methyl-substituted cyclohexanes. Deviations from the general tendencies in the series are correlated with changes in ring conformations around the highly crowded substituted carbons.
Additional Material:
9 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1270110811
