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Fast atom bombardment mass spectra of the bis-guanosine adduct with cisplatin (1982)

Puzo, G. ; Promé, J. C. ; Macquet, J. P. ; [et al.]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 9 (1982), S. 552-556

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ISSN: 0306-042X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Cisplatin, cis-Pt(NH3)2Cl2, is used as an anticancer drug. In the present work, we show that fast atom bombardment mass spectrometry is a useful technique in the structural investigation of a complex containing one molecule of cisplatin and two guanosine molecules. Elemental composition and structures of characteristic ions have been postulated and confirmed by direct isotopic analysis, by the study of their collisional induced dissociation and their metastable spectra. Thus, fast atom bombardment mass spectrometry seems to be a useful tool for the characterization of platinum-nucleosides adducts.

Additional Material: 7 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/bms.1200091210

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