ISSN:
0935-6304
Keywords:
Supercritical fluid extraction
;
SFE modifiers
;
pseudoephedrine
;
suphedrine
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
---The effect of modifier and additive composition upon pseudoephedrine recovery from spiked-sand and Suphedrine tablets was examined. Recovery was shown to be dependent on CO2 density as well as on the addition of an ion pairing agent to the matrix. The presence of methanol in the extraction vessel prior to SFE was shown to play a significant role in the ion-pair extraction process. Recovery was also shown to be a function of ion-pairing reagent composition and concentration. The most successful recovery was obtained in the presence of 1-heptanesulfonic acid (HSA), sodium salt in methanol at a 5:1 molar ratio (reagent to drug). The increased extractability in the presence of ion-pairing reagent was attributed to reduced analyte polarity and analyte-matrix displacement. Alternatively, a matrix-spiked mixture of methanol and 1% water by itself was just as effective as a matrix-spiked mixture of methanol and HSA for attaining efficient extraction. Several in-cell (e. g. to the matrix) and in-line (e. g. to the fluid) modifiers were examined for the extraction of pseudoephedrine from Suphedrine tablets. The greatest pseudoephedrine recovery from Suphedrine tablets of 82% (7.0%) was achieved with 10% (l% H2O) methanol-modified CO2 in the presence of 400 μL of methanol (l% H2O). Finally AgCl tests and infrared analyses were performed on two tablet extracts. It was confirmed that even in the absence of any in-cell modifier, a small fraction of pseudoephedrine hydrochloride could be extracted.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
