ISSN:
0899-0042
Schlagwort(e):
Pseudomonas cepacia
;
lipase PS
;
transesterification
;
kinetic resolution
;
2-substituted 3-hydroxy ester
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Kinetic resolution of 2-substituted 3-hydroxy esters was examined by lipase PS catalyzed transesterification using vinyl acetate as an acyl donor. Resolution of (±)-syn- and -anti-1a, -1e possessing a small methyl group at the C-3 position was accomplished enantioselectively. The outcome of the resolution seems to be related to the differences in size of the substituents at the stereocenter bearing a secondary hydroxy group. Chirality 10:693-698, 1998. © 1998 Wiley-Liss, Inc.
Zusätzliches Material:
1 Ill.
Materialart:
Digitale Medien
