Publication Date:
1998-04-29
Description:
After the vertebrate lens is induced from head ectoderm, lens-specific genes are expressed. Transcriptional regulation of the lens-specific alphaA-crystallin gene is controlled by an enhancer element, alphaCE2. A gene encoding an alphaCE2-binding protein, L-maf(lens-specific maf), was isolated. L-maf expression is initiated in the lens placode and is restricted to lens cells. The gene product L-Maf regulates the expression of multiple genes expressed in the lens, and ectopic expression of this transcription factor converts chick embryonic ectodermal cells and cultured cells into lens fibers. Thus, vertebrate lens induction and differentiation can be triggered by the activation of L-Maf.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ogino, H -- Yasuda, K -- New York, N.Y. -- Science. 1998 Apr 3;280(5360):115-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0101, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9525857" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Basic-Leucine Zipper Transcription Factors
;
Cell Differentiation
;
Cells, Cultured
;
Chick Embryo
;
Crystallins/genetics
;
DNA, Complementary
;
DNA-Binding Proteins/chemistry/genetics
;
Ectoderm
;
Enhancer Elements, Genetic
;
Eye Proteins/genetics
;
G-Box Binding Factors
;
*Gene Expression Regulation, Developmental
;
Genes, Reporter
;
Intermediate Filament Proteins/genetics
;
Lens, Crystalline/*cytology/*embryology/metabolism
;
Maf Transcription Factors
;
Molecular Sequence Data
;
Promoter Regions, Genetic
;
Recombinant Fusion Proteins/metabolism
;
Transcription Factors/chemistry/genetics/*metabolism
;
*Transcription, Genetic
;
Transcriptional Activation
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
