Publication Date:
1998-03-28
Description:
T cells with variable region Vdelta1 gammadelta T cell receptors (TCRs) are distributed throughout the human intestinal epithelium and may function as sentinels that respond to self antigens. The expression of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization. MICA and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vdelta1 gammadelta TCRs. These interactions involved the alpha1alpha2 domains of MICA and MICB but were independent of antigen processing. With intestinal epithelial cell lines, the expression and recognition of MICA and MICB could be stress-induced. Thus, these molecules may broadly regulate protective responses by the Vdelta1 gammadelta T cells in the epithelium of the intestinal tract.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Groh, V -- Steinle, A -- Bauer, S -- Spies, T -- P01 CA18221/CA/NCI NIH HHS/ -- R01 AI30581/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1998 Mar 13;279(5357):1737-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Avenue North, Seattle, WA 98109, USA. vgroh@fred.fhcrc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9497295" target="_blank"〉PubMed〈/a〉
Keywords:
Antigen Presentation
;
Carrier Proteins/analysis/*immunology
;
Cell Line
;
Cytotoxicity, Immunologic
;
Heat-Shock Response
;
Histocompatibility Antigens Class I/analysis/*immunology
;
Hot Temperature
;
Humans
;
Immunophenotyping
;
Intestinal Mucosa/cytology/*immunology
;
Ligands
;
Receptors, Antigen, T-Cell, gamma-delta/*immunology
;
T-Lymphocyte Subsets/*immunology
;
Transfection
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
