Publication Date:
1997-04-25
Description:
The gene encoding the BCL-6 transcriptional repressor is frequently translocated and mutated in diffuse large cell lymphoma. Mice with a disrupted BCL-6 gene developed myocarditis and pulmonary vasculitis, had no germinal centers, and had increased expression of T helper cell type 2 cytokines. The BCL-6 DNA recognition motif resembled sites bound by the STAT (signal transducers and activators of transcription) transcription factors, which mediate cytokine signaling. BCL-6 could repress interleukin-4 (IL-4)-induced transcription when bound to a site recognized by the IL-4-responsive transcription factor Stat6. Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dent, A L -- Shaffer, A L -- Yu, X -- Allman, D -- Staudt, L M -- New York, N.Y. -- Science. 1997 Apr 25;276(5312):589-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9110977" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocytes/immunology
;
Cells, Cultured
;
Cytokines/*biosynthesis
;
DNA-Binding Proteins/genetics/*physiology
;
Ficoll/analogs & derivatives/immunology
;
Germinal Center/*immunology
;
Hemocyanin/immunology
;
Immunoglobulins/biosynthesis
;
Inflammation/*immunology/pathology
;
Interferon-gamma/biosynthesis
;
Interleukin-4/metabolism
;
Interleukins/biosynthesis/metabolism
;
Lymphocyte Activation
;
Mice
;
Myocarditis/immunology/pathology
;
Proto-Oncogene Proteins/genetics/*physiology
;
Proto-Oncogene Proteins c-bcl-6
;
Receptors, IgE/genetics
;
STAT6 Transcription Factor
;
Signal Transduction
;
Spleen/immunology
;
T-Lymphocytes/immunology
;
Th2 Cells/immunology
;
Trans-Activators/metabolism
;
Transcription Factors/genetics/*physiology
;
Transcription, Genetic
;
Trinitrobenzenes/immunology
;
Vasculitis/immunology/pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
