Publication Date:
1996-12-06
Description:
The DPY-26 protein is required in the nematode Caenorhabditis elegans for X-chromosome dosage compensation as well as for proper meiotic chromosome segregation. DPY-26 was shown to mediate both processes through its association with chromosomes. In somatic cells, DPY-26 associates specifically with hermaphrodite X chromosomes to reduce their transcript levels. In germ cells, DPY-26 associates with all meiotic chromosomes to mediate its role in chromosome segregation. The X-specific localization of DPY-26 requires two dosage compensation proteins (DPY-27 and DPY-30) and two proteins that coordinately control both sex determination and dosage compensation (SDC-2 and SDC-3).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lieb, J D -- Capowski, E E -- Meneely, P -- Meyer, B J -- GM30702/GM/NIGMS NIH HHS/ -- HD24324/HD/NICHD NIH HHS/ -- T32 GM07127/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 6;274(5293):1732-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8939869" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Caenorhabditis elegans/embryology/genetics/*physiology
;
*Caenorhabditis elegans Proteins
;
Carrier Proteins/physiology
;
Cell Nucleus/chemistry
;
Chromosomes/*physiology
;
Disorders of Sex Development
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*Dosage Compensation, Genetic
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Embryonic Development
;
Female
;
Gene Expression
;
Genes, Helminth
;
Germ Cells/physiology
;
Helminth Proteins/analysis/genetics/*physiology
;
Male
;
*Meiosis
;
Molecular Sequence Data
;
Mutation
;
Nuclear Proteins/physiology
;
X Chromosome/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
