Publication Date:
1995-10-06
Description:
Major histocompatibility complex (MHC) class I molecules bind peptides that are delivered from the cytosol into the endoplasmic reticulum by the MHC-encoded transporter associated with antigen processing (TAP). Peptide capture by immature heterodimers of class I heavy chains and beta 2-microglobulin may be facilitated by their physical association with TAP. A genetic defect in a human mutant cell line causes the complete failure of diverse class I heterodimers to associate with TAP. This deficiency impairs the ability of the class I heterodimers to efficiently capture peptides and results from loss of function of an unidentified gene or genes linked to the MHC.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grandea, A G 3rd -- Androlewicz, M J -- Athwal, R S -- Geraghty, D E -- Spies, T -- AI30581/AI/NIAID NIH HHS/ -- AI38508/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1995 Oct 6;270(5233):105-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569935" target="_blank"〉PubMed〈/a〉
Keywords:
ATP-Binding Cassette Transporters/*metabolism
;
Amino Acid Sequence
;
Calcium-Binding Proteins/metabolism
;
Calnexin
;
Cell Line
;
Endoplasmic Reticulum/metabolism
;
HLA Antigens/metabolism
;
HLA-A1 Antigen/metabolism
;
HLA-B Antigens/metabolism
;
HLA-B8 Antigen/metabolism
;
HLA-G Antigens
;
Histocompatibility Antigens Class I/*metabolism
;
Humans
;
Ligands
;
*Major Histocompatibility Complex/genetics
;
Molecular Sequence Data
;
Mutation
;
Peptides/*metabolism
;
Transfection
;
beta 2-Microglobulin/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
