Publication Date:
1987-12-04
Description:
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leppert, M -- Dobbs, M -- Scambler, P -- O'Connell, P -- Nakamura, Y -- Stauffer, D -- Woodward, S -- Burt, R -- Hughes, J -- Gardner, E -- CA40641/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Dec 4;238(4832):1411-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Human Genetics, University of Utah Medical Center, Salt Lake City 84132.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3479843" target="_blank"〉PubMed〈/a〉
Keywords:
Chromosome Mapping
;
*Chromosomes, Human, Pair 5
;
Colonic Polyps/*genetics
;
Female
;
Gardner Syndrome/genetics
;
*Genes
;
Genetic Markers
;
Humans
;
Lod Score
;
Male
;
Neoplasms, Multiple Primary/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
