Publication Date:
1992-10-23
Description:
Advanced glycosylation end products (AGEs) form spontaneously from glucose-derived Amadori products and accumulate on long-lived tissue proteins. AGEs have been implicated in the pathogenesis of several of the complications of aging and diabetes, including atherosclerosis and renal disease. With the use of recently developed AGE-specific antibodies, an AGE-modified form of human hemoglobin has been identified. Termed hemoglobin-AGE (Hb-AGE), this modified species accounts for 0.42 percent of circulating hemoglobin in normal individuals but increases to 0.75 percent in patients with diabetes-induced hyperglycemia. In a group of diabetic patients treated with the advanced glycosylation inhibitor aminoguanidine, Hb-AGE levels decreased significantly over a 1-month period. Hemoglobin-AGE measurements may provide an index of long-term tissue modification by AGEs and prove useful in assessing the contribution of advanced glycosylation to a variety of diabetic and age-related complications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makita, Z -- Vlassara, H -- Rayfield, E -- Cartwright, K -- Friedman, E -- Rodby, R -- Cerami, A -- Bucala, R -- DK19655-15/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1992 Oct 23;258(5082):651-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Picower Institute for Medical Research, Manhasset, NY 11030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1411574" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Aging/*blood
;
Biomarkers/blood
;
Diabetes Mellitus, Type 1/*blood/drug therapy
;
Diabetes Mellitus, Type 2/*blood/drug therapy
;
Enzyme-Linked Immunosorbent Assay
;
Glycosylation
;
Guanidines/*therapeutic use
;
Hemoglobins/*analysis
;
Humans
;
Middle Aged
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
