Publication Date:
2010-11-13
Description:
Experience-dependent brain plasticity typically declines after an early critical period during which circuits are established. Loss of plasticity with closure of the critical period limits improvement of function in adulthood, but the mechanisms that change the brain's plasticity remain poorly understood. Here, we identified an increase in expression of Lynx1 protein in mice that prevented plasticity in the primary visual cortex late in life. Removal of this molecular brake enhanced nicotinic acetylcholine receptor signaling. Lynx1 expression thus maintains stability of mature cortical networks in the presence of cholinergic innervation. The results suggest that modulating the balance between excitatory and inhibitory circuits reactivates visual plasticity and may present a therapeutic target.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387538/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387538/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morishita, Hirofumi -- Miwa, Julie M -- Heintz, Nathaniel -- Hensch, Takao K -- 1 DP1 OD003699-01/OD/NIH HHS/ -- DA-17279/DA/NIDA NIH HHS/ -- DP1 OD003699/OD/NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Nov 26;330(6008):1238-40. doi: 10.1126/science.1195320. Epub 2010 Nov 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉FM Kirby Neurobiology Center, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21071629" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Amblyopia/metabolism
;
Animals
;
Cholinesterase Inhibitors/pharmacology
;
Dominance, Ocular
;
Evoked Potentials, Visual
;
Mecamylamine/pharmacology
;
Membrane Glycoproteins/*genetics/metabolism/*physiology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Neural Inhibition
;
*Neuronal Plasticity
;
Neuropeptides/*genetics/metabolism/*physiology
;
Nicotinic Antagonists/pharmacology
;
Physostigmine/pharmacology
;
Receptors, Nicotinic/genetics/*metabolism
;
Sensory Deprivation
;
Signal Transduction
;
*Vision, Ocular
;
Visual Cortex/*physiology
;
Visual Pathways
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
