Publication Date:
2010-10-30
Description:
Prions are an unusual form of epigenetics: Their stable inheritance and complex phenotypes come about through protein folding rather than nucleic acid-associated changes. With intimate ties to protein homeostasis and a remarkable sensitivity to stress, prions are a robust mechanism that links environmental extremes with the acquisition and inheritance of new traits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Halfmann, Randal -- Lindquist, Susan -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Oct 29;330(6004):629-32. doi: 10.1126/science.1191081.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21030648" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological
;
Biological Evolution
;
*Epigenesis, Genetic
;
Genetic Variation
;
Homeostasis
;
Peptide Termination Factors/chemistry/metabolism/physiology
;
Phenotype
;
Prions/*chemistry/metabolism/*physiology
;
Protein Conformation
;
Protein Folding
;
Protein Structure, Tertiary
;
Saccharomyces cerevisiae/genetics/metabolism
;
Saccharomyces cerevisiae Proteins/chemistry/metabolism/physiology
;
Stress, Physiological
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
