Publication Date:
2009-07-11
Description:
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812811/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812811/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Colman, Ricki J -- Anderson, Rozalyn M -- Johnson, Sterling C -- Kastman, Erik K -- Kosmatka, Kristopher J -- Beasley, T Mark -- Allison, David B -- Cruzen, Christina -- Simmons, Heather A -- Kemnitz, Joseph W -- Weindruch, Richard -- P01 AG-11915/AG/NIA NIH HHS/ -- P01 AG011915/AG/NIA NIH HHS/ -- P01 AG011915-11A29002/AG/NIA NIH HHS/ -- P51 RR000167/RR/NCRR NIH HHS/ -- RR020141-01/RR/NCRR NIH HHS/ -- RR15459-01/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2009 Jul 10;325(5937):201-4. doi: 10.1126/science.1173635.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. rcolman@primate.wisc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19590001" target="_blank"〉PubMed〈/a〉
Keywords:
*Aging
;
Animals
;
Atrophy/epidemiology/prevention & control
;
Body Weight
;
Brain/*pathology
;
*Caloric Restriction
;
Cardiovascular Diseases/epidemiology/*prevention & control
;
Diabetes Mellitus/epidemiology/*prevention & control
;
Female
;
Glucose/metabolism
;
Incidence
;
*Longevity
;
Macaca mulatta
;
Male
;
Neoplasms/epidemiology/*prevention & control
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
