Publication Date:
2010-04-17
Description:
When the food intake of organisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fed a normal diet. A similar effect is seen when the activity of nutrient-sensing pathways is reduced by mutations or chemical inhibitors. In rodents, both dietary restriction and decreased nutrient-sensing pathway activity can lower the incidence of age-related loss of function and disease, including tumors and neurodegeneration. Dietary restriction also increases life span and protects against diabetes, cancer, and cardiovascular disease in rhesus monkeys, and in humans it causes changes that protect against these age-related pathologies. Tumors and diabetes are also uncommon in humans with mutations in the growth hormone receptor, and natural genetic variants in nutrient-sensing pathways are associated with increased human life span. Dietary restriction and reduced activity of nutrient-sensing pathways may thus slow aging by similar mechanisms, which have been conserved during evolution. We discuss these findings and their potential application to prevention of age-related disease and promotion of healthy aging in humans, and the challenge of possible negative side effects.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607354/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607354/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fontana, Luigi -- Partridge, Linda -- Longo, Valter D -- AG025135/AG/NIA NIH HHS/ -- AG20642/AG/NIA NIH HHS/ -- GM075308/GM/NIGMS NIH HHS/ -- P30 DK056341/DK/NIDDK NIH HHS/ -- P30DK056341/DK/NIDDK NIH HHS/ -- R01 AG020642/AG/NIA NIH HHS/ -- UL1 RR024992/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO 63110, USA. lfontana@dom.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20395504" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Caenorhabditis elegans/genetics/physiology
;
*Caloric Restriction
;
Drosophila/genetics/physiology
;
Eating
;
Haplorhini
;
Humans
;
*Longevity
;
Mice
;
Saccharomyces cerevisiae/genetics/physiology
;
*Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
