Publication Date:
2006-07-22
Description:
Brassinosteroids, the steroid hormones of plants, are perceived at the plasma membrane by a leucine-rich repeat receptor serine/threonine kinase called BRI1. We report a BRI1-interacting protein, BKI1, which is a negative regulator of brassinosteroid signaling. Brassinosteroids cause the rapid dissociation of BKI1-yellow fluorescent protein from the plasma membrane in a process that is dependent on BRI1-kinase. BKI1 is a substrate of BRI1 kinase and limits the interaction of BRI1 with its proposed coreceptor, BAK1, suggesting that BKI1 prevents the activation of BRI1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Xuelu -- Chory, Joanne -- New York, N.Y. -- Science. 2006 Aug 25;313(5790):1118-22. Epub 2006 Jul 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Plant Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16857903" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Arabidopsis/*metabolism
;
Arabidopsis Proteins/chemistry/genetics/*metabolism
;
Brassinosteroids
;
Cell Membrane/*metabolism
;
Cholestanols/*metabolism/pharmacology
;
Gene Expression Regulation, Plant
;
Meristem/metabolism
;
Molecular Sequence Data
;
Nuclear Proteins/metabolism
;
Phosphorylation
;
Plants, Genetically Modified
;
Protein Binding
;
Protein Kinases/chemistry/genetics/*metabolism
;
Protein Structure, Tertiary
;
RNA Interference
;
Recombinant Fusion Proteins/metabolism
;
*Signal Transduction
;
Steroids, Heterocyclic/*metabolism/pharmacology
;
Two-Hybrid System Techniques
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
