Publication Date:
2005-04-30
Description:
Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yarovinsky, Felix -- Zhang, Dekai -- Andersen, John F -- Bannenberg, Gerard L -- Serhan, Charles N -- Hayden, Matthew S -- Hieny, Sara -- Sutterwala, Fayyaz S -- Flavell, Richard A -- Ghosh, Sankar -- Sher, Alan -- 1R01AI045806-01A1/AI/NIAID NIH HHS/ -- AI05093/AI/NIAID NIH HHS/ -- R01-AI59440/AI/NIAID NIH HHS/ -- R01-GM38765/GM/NIGMS NIH HHS/ -- Intramural NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2005 Jun 10;308(5728):1626-9. Epub 2005 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunobiology Section, Laboratory of Parasitic Diseases; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. fyarovinsky@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860593" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptor Proteins, Signal Transducing
;
Amino Acid Motifs
;
Amino Acid Sequence
;
Animals
;
Antigens, Differentiation/genetics/metabolism
;
Contractile Proteins/chemistry/*immunology/isolation & purification/metabolism
;
Dendritic Cells/*immunology
;
Genes, Protozoan
;
Immunity, Innate
;
Interleukin-12/biosynthesis/blood
;
Ligands
;
Membrane Glycoproteins/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Microfilament Proteins/chemistry/*immunology/isolation & purification/metabolism
;
Molecular Sequence Data
;
Myeloid Differentiation Factor 88
;
NF-kappa B/metabolism
;
Profilins
;
Protozoan Proteins/chemistry/*immunology/isolation & purification/metabolism
;
Receptors, Cell Surface/*metabolism
;
Receptors, Immunologic/genetics/metabolism
;
Recombinant Proteins/immunology
;
Signal Transduction
;
Toll-Like Receptors
;
Toxoplasma/genetics/*immunology
;
Toxoplasmosis, Animal/*immunology
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
