Publication Date:
2005-04-23
Description:
In eukaryotes, 21- to 24-nucleotide-long RNAs engage in sequence-specific interactions that inhibit gene expression by RNA silencing. This process has regulatory roles involving microRNAs and, in plants and insects, it also forms the basis of a defense mechanism directed by small interfering RNAs that derive from replicative or integrated viral genomes. We show that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells. PFV-1 also encodes a protein, Tas, that suppresses microRNA-directed functions in mammalian cells and displays cross-kingdom antisilencing activities. Therefore, through fortuitous recognition of foreign nucleic acids, cellular microRNAs have direct antiviral effects in addition to their regulatory functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lecellier, Charles-Henri -- Dunoyer, Patrice -- Arar, Khalil -- Lehmann-Che, Jacqueline -- Eyquem, Stephanie -- Himber, Christophe -- Saib, Ali -- Voinnet, Olivier -- New York, N.Y. -- Science. 2005 Apr 22;308(5721):557-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS Unite Propre de Recherche (UPR) 2357, Institut de Biologie Moleculaire des Plantes, 12 rue du General Zimmer, 67084 Strasbourg Cedex, France. charles.lecellier@infobiogen.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15845854" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antiviral Agents/*physiology
;
Arabidopsis/genetics
;
Cell Line
;
Cricetinae
;
DNA-Binding Proteins/genetics/metabolism
;
Genes, Reporter
;
Green Fluorescent Proteins/genetics
;
HeLa Cells
;
Humans
;
MicroRNAs/*physiology
;
Oligonucleotides, Antisense
;
Plants, Genetically Modified
;
Protein Biosynthesis
;
*RNA Interference
;
RNA, Viral
;
Retroviridae Proteins/genetics/metabolism
;
Spumavirus/*genetics/*physiology
;
Trans-Activators/genetics/metabolism
;
Transfection
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
