Publication Date:
2003-03-01
Description:
Although curvature of biological surfaces has been considered from mathematical and biophysical perspectives, its molecular and developmental basis is unclear. We have studied the cin mutant of Antirrhinum, which has crinkly rather than flat leaves. Leaves of cin display excess growth in marginal regions, resulting in a gradual introduction of negative curvature during development. This reflects a change in the shape and the progression of a cell-cycle arrest front moving from the leaf tip toward the base. CIN encodes a TCP protein and is expressed downstream of the arrest front. We propose that CIN promotes zero curvature (flatness) by making cells more sensitive to an arrest signal, particularly in marginal regions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nath, Utpal -- Crawford, Brian C W -- Carpenter, Rosemary -- Coen, Enrico -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1404-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610308" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Antirrhinum/cytology/*genetics/*growth & development/metabolism
;
Base Sequence
;
Cell Cycle
;
Cell Differentiation
;
Cell Division
;
Cell Size
;
Cyclin D3
;
Cyclins/genetics/metabolism
;
Gene Deletion
;
*Gene Expression Regulation, Plant
;
*Genes, Plant
;
Histones/genetics/metabolism
;
Molecular Sequence Data
;
Mutagenesis, Insertional
;
Mutation
;
Plant Leaves/anatomy & histology/cytology/*growth & development/metabolism
;
Plant Proteins/chemistry/genetics/metabolism
;
Surface Properties
;
Transcription Factors/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
