Publication Date:
2002-11-02
Description:
Ion channels on the mitochondrial inner membrane influence cell function in specific ways that can be detrimental or beneficial to cell survival. At least one type of potassium (K+) channel, the mitochondrial adenosine triphosphate-sensitive K+ channel (mitoKATP), is an important effector of protection against necrotic and apoptotic cell injury after ischemia. Here another channel with properties similar to the surface membrane calcium-activated K+ channel was found on the mitochondrial inner membrane (mitoKCa) of guinea pig ventricular cells. MitoKCa significantly contributed to mitochondrial K+ uptake of the myocyte, and an opener of mitoKCa protected hearts against infarction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Wenhong -- Liu, Yongge -- Wang, Sheng -- McDonald, Todd -- Van Eyk, Jennifer E -- Sidor, Agnieszka -- O'Rourke, Brian -- NIHR01HL54598/HR/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):1029-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411707" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/metabolism
;
Animals
;
Benzimidazoles/pharmacology
;
Calcium/*metabolism
;
Charybdotoxin/pharmacology
;
*Cytoprotection
;
Guinea Pigs
;
Heart/physiology/physiopathology
;
Hemodynamics
;
Intracellular Membranes/*metabolism
;
Ion Transport
;
Large-Conductance Calcium-Activated Potassium Channels
;
Mitochondria, Heart/*metabolism
;
Myocardial Infarction/*prevention & control
;
Myocardial Ischemia/pathology/physiopathology
;
Myocytes, Cardiac/*physiology/ultrastructure
;
Patch-Clamp Techniques
;
Potassium/*metabolism
;
Potassium Channels, Calcium-Activated/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
