ISSN:
0360-6376
Keywords:
Physics
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The polymerization of α-amino acid N-carboxy anhydrides (NCAs) initiated by 4-aminoethylimidazole (histamine) was studied in order to synthesize poly(amino acids) containing an imidazole nucleus at the end of polymer chain. On the basis of the kinetical measurements, it was found that the rate of polymerization is proportional to the first order in both NCA and initiator concentrations and that the initiation reaction is predominantly caused by the primary amine with the highest basicity in a histamine molecule. Binding of the histamine fragment to the end of polymer chain was confirmed by elementary analysis, nuclear magnetic resonance spectroscopy, and measuring the number-average molecular weight of the resulting polymers. It was thus possible to prepare poly(amino acids) with a pendant histamine. In addition, the lowering of the number-average degree of polymerization of the polymers prepared was observed under the condition that the initial molar ratio of NCA to histamine was larger. It was caused by the reinitiation of polymerization by the imidazole nucleus at the chain end.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/pol.1975.170130801
