ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Isoquinolines, 1. Synthesis of 3,3-Dialkyl Substituted 3,4-Dihydro- and 1,2,3,4-TetrahydroisoquinolinesDialkyl benzyl carbonium ions 12 react with nitriles under the conditions of the Graf-Ritter reaction to give 3,3-dialkyl-3,4-dihydroisoquinolines 9. 3,3-Dialkyl-1,2,3,4-tetrahydroisoquinolines 26 are prepared by reduction of dihydroisoquinolines as well as by Pictet-Spengler ring closure.
Notes:
Dialkyl-benzyl-carbonium-Ionen 12 reagieren mit Nitrilen unter den Bedingungen der Graf-Ritter-Reaktion zu 3.3-dialkylsubstituierten 3.4-Dihydro-isochinolinen 9. 3.3-Dialkylsubstituierte 1.2.3.4-Tetrahydro-isochinoline 26 lassen sich außer durch Reduktion entsprechender Dihydro-isochinoline auch durch Pictet-Spengler-Ringschluß darstellen.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19701030604
