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  • Springer Science + Business Media
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  • 101
    Publication Date: 2017-04-04
    Description: For 5 months before the 2001 Mt. Etna eruption, a progressive gravity decrease was measured along a profile of stations on the southern slope of the volcano. Between January and July 2001, the amplitude of the change reached 80 μGal, while the wavelength of the anomaly was of the order of 15 km. Elevation changes observed through GPS measurements during a period encompassing the 5-month gravity decrease, remained within 4–6 cm over the entire volcano and within 2–4 cm in the zone covered by the microgravity profile. We review both gravity and elevation changes by a model assuming the formation of new cracks, uniformly distributed in a rectangular prism. The inversion problem was formulated following a global optimization approach based on the use of Genetic Algorithms. Although it is possible to explain the observed gravity changes by means of the proposed analytical formulation, the results show that calculated elevation changes are significantly higher than those observed. Two alternative hypotheses are proposed to account for this apparent discrepancy: (1) that the assumptions behind the analytical formulation, used to invert the data, are fallacious at Etna, and thus, numerical models should be utilized; (2) that a second process, enabling a considerable mass decrease to occur without deformation, acted together with the formation of new cracks in the source volume.
    Description: Published
    Description: 553–562
    Description: 2.6. TTC - Laboratorio di gravimetria, magnetismo ed elettromagnetismo in aree attive
    Description: JCR Journal
    Description: reserved
    Keywords: Gravity ; Elastic modeling ; 04. Solid Earth::04.03. Geodesy::04.03.05. Gravity variations
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 102
    Publication Date: 2017-04-04
    Description: This work presents a methodology to study the interannual variability associated with summertime months in which extremely hot temperatures are frequent. Daily time series of maximum and minimum temperature fields (T max and T min, respectively) are used to define indexes of extreme months based on the number of days crossing thresholds. An empirical orthogonal function (EOF) analysis is applied to the monthly indexes. EOF loadings give information about the geographical areas where the number of days per month with extreme temperatures has the largest variability. Correlations between the EOF principal components and the time series of other fields allow plotting maps highlighting the anomalies in the large scale circulation and in the SSTs that are associated with the occurrence of extreme events. The methodology is used to construct the “climatology” of the extremely hot summertime months over Europe. In terms of both interannual and intraseasonal variability, there are three regions in which the frequency of the extremely hot days per month homogeneously varies: north-west Europe, Euro-Mediterranean and Eurasia region. Although extremes over those regions occur during the whole summer (June to August), the anomalous climatic conditions associated with frequent heatwaves present some intraseasonal variability. Extreme climate events over the north-west Europe and Eurasia are typically related to the occurrence of blocking situations. The intraseasonal variability of those patterns is related to the amplitude of the blocking, the relative location of the action centre and the wavetrain of anomalies downstream or upstream of the blocking. During June and July, blocking situations which give extremely hot climate conditions over north-west Europe are also associated with cold conditions over the eastern Mediterranean sector. The Euro-Mediterranean region is a transition area in which extratropical and tropical systems compete, influencing the occurrence of climate events: blockings tend to be related to extremely hot months during June while baroclinic anomalies dominate the variability of the climate events in July and August. We highlight that our method could be easily applied to other regions of the world, to other fields as well as to model outputs to assess, e.g. the potential change of extreme climate events in a warmer climate.
    Description: Published
    Description: 77-98
    Description: 3.7. Dinamica del clima e dell'oceano
    Description: JCR Journal
    Description: open
    Keywords: Extreme events ; Heatwaves ; Temperature anomalies ; climate variability ; 01. Atmosphere::01.01. Atmosphere::01.01.02. Climate
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 103
    Publication Date: 2017-04-04
    Description: The main purpose of this paper is to introduce a Bayesian event tree model for eruption forecasting (BET_EF). The model represents a flexible tool to provide probabilities of any specific event at which we are interested in, by merging all the relevant available information, such as theoretical models, a priori beliefs, monitoring measures, and any kind of past data. BET_EF is based on a Bayesian procedure and it relies on the fuzzy approach to manage monitoring data. The method deals with short- and long-term forecasting, therefore it can be useful in many practical aspects, as land use planning, and during volcanic emergencies. Finally, we provide the description of a free software package that provides a graphically supported computation of short- to long-term eruption forecasting, and a tutorial application to the recent MESIMEX exercise at Vesuvius.
    Description: Published
    Description: 623-632
    Description: 4.3. TTC - Scenari di pericolosità vulcanica
    Description: JCR Journal
    Description: partially_open
    Keywords: eruption forecasting ; event tree ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 104
    Publication Date: 2017-04-04
    Description: Fluorine is one of the many environmental harmful elements released by volcanic activity. The content of total, oxalate extractable and water extractable fluorine was determined in 96 topsoils of three active volcanic systems of southern Italy (Mt. Etna, Stromboli and Vulcano). Total fluorine content (FTOT) ranges from 112 to 7430 mg kg-1, F extracted with oxalate (FOX) ranges from 16 to 2320 mg kg-1 (2 – 93 % of FTOT) and F extracted with distilled water (FH2O) ranges from 1.7 to 159 mg kg-1 (0.2 – 40 % of FTOT). Fluorine in the sampled topsoils derives both from the weathering of volcanic rocks and ashes and from enhanced deposition due to volcanic gas emissions either from open-conduit passive degassing (Mt. Etna and Stromboli) or from a fumarolic field (Vulcano). Fluorine accumulation in the studied soils does generally not present particular environmental issues except for a few anomalous sites at Vulcano where measured contents could be dangerous both for vegetation and for grazing animals.
    Description: Published
    Description: 413-423
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: reserved
    Keywords: soil fluorine ; oxalate extractable F ; water extractable F ; environmental impact of volcanic F ; Sicily ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 105
    Publication Date: 2017-04-04
    Description: While the seismicity of the Southern Alps is high in the Eastern sector, corresponding to the Veneto and Friuli regions, it decreases towards West up to the Adda River. In the sector between the Lessini Mts. and Eastern Friuli the damaging earthquakes are clustered in a well defined seismic belt, where seismogenic sources responsible for earthquakes with Mw 6 have been defined in recent works. In contrast, the knowledge of the Southalpine sector West of this area is sparser; the area experienced some earthquakes with Mw〉5.5 and varied events with 4.8≤Mw≤5.5 the distribution of which is, apparently, random. For the area roughly defined by the basins of the Adda River to the West and the middle Adige River to the East, this paper reappraises the background knowledge of the earthquakes occurred before 1700. The investigation and the results are presented according to two successive periods, up to 1995 and from 1995 on. In the research performed up to 1995, the most important achievements concerned two different aspects: i) the assessement of several “fake quakes”, some of which were the object of paradigmatic case-histories; ii) the resizing and relocation of several, presumed damaging earthquakes. Though this round of investigation changed significantly the picture of the seismicity with respect to the Seventies, the research continued. For the period from 1995 on, the discussion focuses on the reliability of the available information; material that received little or no consideration before, new historical findings and comments to the seismological interpretation as in the most recent literature are also presented. This part includes also the discussion of archaeoseismological evidence of damage related to past earthquakes.
    Description: Published
    Description: 93-129
    Description: 3.10. Sismologia storica e archeosismologia
    Description: reserved
    Keywords: historical seismology ; Adda and Middle Adige River Basins ; Southern Alps ; archaeoseismology ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 106
    Publication Date: 2017-04-04
    Description: National seismic risk maps are an important risk mitigation tool as they can be used for the prioritization of regions within a country where retrofitting of the building stock or other risk mitigation measures should take place. The production of a seismic risk map involves the convolution of seismic hazard data, vulnerability predictions for the building stock and exposure data. The seismic risk maps produced in Italy over the past 10 years are compared in this paper with recent proposals for seismic risk maps based on state-of-the-art seismic hazard data and mechanics-based vulnerability assessment procedures. The aim of the paper is to open the discussion for the way in which future seismic risk maps could be produced, making use of the most up-to-date information in the fields of seismic hazard evaluation and vulnerability assessment.
    Description: Italian Ministry of Research and Higher Education (MIUR—Ministero dell’Università e della Ricerca) through the financing of the project AIRPLANE (Advancing Interdisciplinary Research PLAtform on volcanoes aNd Earthquakes)
    Description: In press
    Description: 4.2. TTC - Scenari e mappe di pericolosità sismica
    Description: JCR Journal
    Description: reserved
    Keywords: Seismic risk ; Seismic hazard ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 107
    Publication Date: 2017-04-03
    Description: The Valtiberina region (central Italy) has a seismic record going back to the Middle Ages and including five Io 〉 VIII MCS earthquakes, the earliest of which (1352, 1389, 1458). though recently and extensively studied, remain rather poorly known. This makes it all the more important to ensure that the later ones (1789, 1917) are as throughly studied as possible. The 1789 earthquake is listed by the current Italian catalogue (CPTI Working Group 2004) with Io VIII-IX MCS and Mm 5.8. These parameters were assessed from a database of 28 macroseismic intensity data points (Castelli et al. 1996), which is less than plentiful for a late 18th century earthquake. An analysis of the historical context of the 1789 earthquake and its influence on the production of contemporary accounts evidences a few research paths that previous studies either did not or could not take. Following them, the macroseismic database of the 1789 earthquake can be noticeably improved, providing the catalogue compiler with a mean to check the reliability of its current parameters.
    Description: Published
    Description: 249-260
    Description: 5.1. TTC - Banche dati e metodi macrosismici
    Description: open
    Keywords: Historical Seismicity ; 1789 Valtiberina Earthquake ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 108
    Publication Date: 2017-04-04
    Description: We consider the process of slow extrusion of very viscous magma that forms lava domes. Dome-building eruptions are commonly associated with hazardous phenomena, in- cluding pyroclastic flows generated by dome collapses, explosive eruptions and volcanic blasts. These eruptions commonly display fairly regular alternations between pe- riods of high and low or no activity with time scales from hours to years. Usually hazardous phenomena are asso- ciated with periods of high magma discharge rate, thus, understanding the causes of pulsatory activity during ex- trusive eruptions is an important step towards forecasting volcanic behavior, especially the transition to explosive ac- tivity when magma discharge rate increases by a few orders of magnitude. In recent years the risks have increased be- cause the population density in the vicinity of many active volcanoes has increased.
    Description: Published
    Description: 3.6. Fisica del vulcanismo
    Description: open
    Keywords: Volcanic Eruptions ; Cyclicity ; During Lava ; 04. Solid Earth::04.01. Earth Interior::04.01.99. General or miscellaneous ; 04. Solid Earth::04.08. Volcanology::04.08.04. Thermodynamics ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 109
    Publication Date: 2017-04-04
    Description: We show the magnetic model of the Selli-Vavilov region. The Selli Line is known as the northwestern edge of the southern Tyrrhenian basin. The tectonic evolution of the Tyrrhenian basin is dominated by a Tortonian - Quaternary extension through the eastward movement of the Apennine subduction system. This migration has generated a diffuse stretching of the continental crust with the emplacement of new oceanic material. This latter occurred in several localized zones where the eastward retreating of the Ionian subduction system produced a strong depletion of the crust with formation of basins and correlated spreading. Nowadays the presence of oceanic crust is confirmed through direct drilling investigation but a complete mapping of the oceanic crustal distribution is still lacking. The Selli-Vavilov region shows a differentiated crustal setting where seamount structures, the oceanic basement portions and continental crust blocks are superimposed. To this aim, a 2D inversion of the magnetic data of this region was conducted to define buried structures. The magnetic susceptibility pattern was computed by solving the least squares problem of the misfit between the predicted and real data for separated wavebands. This method produced two 2D models of the high and low frequency fields of the Selli-Vavilov region. The two apparent susceptibility maps provide different information for distinct ranges of depth. The results of the inversions were also combined with seismic data of the Selli region highlighting the position of the highly-magnetized buried bodies. The results confirm a role for the Selli Line as a deep crustal boundary dividing the Sardinian passive domain from the easternmost active region where different oceanic structures are located. The Selli Line has worked as a detachment fault system which has moved eastward. Finally, the Selli-Vavilov region may be interpreted as a tectonic result due to a passive asymmetrical rift occurred between the Tortonian and Pliocene.
    Description: Published
    Description: 251-266
    Description: 2.6. TTC - Laboratorio di gravimetria, magnetismo ed elettromagnetismo in aree attive
    Description: 3.4. Geomagnetismo
    Description: 3.5. Geologia e storia dei sistemi vulcanici
    Description: JCR Journal
    Description: reserved
    Keywords: Geomagnetism ; Tectonics ; Geodynamics ; Inversion ; Oceanic crust ; Volcanic structure ; 04. Solid Earth::04.05. Geomagnetism::04.05.04. Magnetic anomalies ; 04. Solid Earth::04.07. Tectonophysics::04.07.02. Geodynamics ; 05. General::05.01. Computational geophysics::05.01.03. Inverse methods
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 110
    Publication Date: 2017-04-04
    Description: Cross-spectral analysis of ULF wave measurements recorded at ground magnetometer stations closely spaced in latitude allows accurate determinations of magnetospheric field line resonance (FLR) frequencies. This is a useful tool for remote sensing temporal and spatial variations of the magnetospheric plasma mass density. The spatial configuration of the South European GeoMagnetic Array (SEGMA, 1.56 〈 L 〈 1.89) offers the possibility to perform such studies at low latitudes allowing to monitor the dynamical coupling between the ionosphere and the inner plasmasphere. As an example of this capability we present the results of a cross-correlation analysis between FLR frequencies and solar EUV irradiance (as monitored by the 10.7-cm solar radio flux F10.7) suggesting that changes in the inner plasmasphere density follow the short-term (27-day) variations of the solar irradiance with a time delay of 1–2 days. As an additional example we present the results of a comparative analysis of FLR measurements, ionospheric vertical soundings and vertical TEC measurements during the development of a geomagnetic storm.
    Description: Published
    Description: 25-27
    Description: 1.6. Osservazioni di geomagnetismo
    Description: 1.7. Osservazioni di alta e media atmosfera
    Description: 3.9. Fisica della magnetosfera, ionosfera e meteorologia spaziale
    Description: JCR Journal
    Description: reserved
    Keywords: ULF waves ; Field line resonance ; Remote sensing ; Solar activity ; Plasmasphere ; Ionosphere ; 01. Atmosphere::01.02. Ionosphere::01.02.02. Dynamics ; 01. Atmosphere::01.02. Ionosphere::01.02.04. Plasma Physics ; 01. Atmosphere::01.03. Magnetosphere::01.03.03. Magnetospheric physics ; 05. General::05.07. Space and Planetary sciences::05.07.01. Solar-terrestrial interaction
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 111
    Publication Date: 2017-04-04
    Description: Following the 2001 and 2002–2003 flank eruptions, activity resumed at Mt. Etna on 7 September 2004 and lasted for about 6 months. This paper presents new petrographic, major and trace element, and Sr–Nd isotope data from sequential samples collected during the entire 2004–2005 eruption. The progressive change of lava composition allowed defining three phases that correspond to different processes controlling magma dynamics inside the central volcano conduits. The compositional variability of products erupted up to 24 September is well reproduced by a fractional crystallization model that involves magma already stored at shallow depth since the 2002–2003 eruption. The progressive mixing of this magma with a distinct new one rising within the central conduits is clearly revealed by the composition of the products erupted from 24 September to 15 October. After 15 October, the contribution from the new magma gradually becomes predominant, and the efficiency of the mixing process ensures the emission of homogeneous products up to the end of the eruption. Our results give insights into the complex conditions of magma storage and evolution in the shallow plumbing system of Mt. Etna during a flank eruption. Furthermore, they confirm that the 2004–2005 activity at Etna was triggered by regional movements of the eastern flank of the volcano. They caused the opening of a complex fracture zone extending ESE which drained a magma stored at shallow depth since the 2002–2003 eruption. This process favored the ascent of a different magma in the central conduits, which began to be erupted on 24 September without any significant change in eruptive style, deformation, and seismicity until the end of eruption.
    Description: Published
    Description: 781–793
    Description: 2.3. TTC - Laboratori di chimica e fisica delle rocce
    Description: JCR Journal
    Description: reserved
    Keywords: Geochemistry ; Isotopic compositions ; Magma feeding system ; Magma mixing ; Mt. Etna ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 112
    Publication Date: 2019-01-30
    Description: Within the framework of the European LESSLOSS Project “Risk Mitigation for Earthquakes and Landslides”, finite-fault seismological models have been proposed for the computation of earthquake scenarios for three urban areas: Istanbul (Turkey), Lisbon (Portugal) and Thessaloniki (Greece). For each case study, ground motion scenarios were developed for the two most probable events with different return periods (generally 50 and 500 years), locations and magnitudes that were derived from historical and geological data. The ground motion simulations were performed in the frequency band of engineering interest (0.5-20 Hz) by two numerical finite-fault methods: a hybrid deterministic-stochastic method, DSM, used for all of the cases investigated, and a non-stationary stochastic finite-fault simulation method, RSSIM, applied only in the case of Lisbon. In the present study, the results with respect to bedrock and surface are presented in terms of peak ground acceleration (PGA) for the city of Lisbon and the surrounding area, using earthquake scenarios from the onshore source area of the Lower Tagus Valley, and from the offshore source area of the Marques de Pombal fault, which is one of the possible sources of the 1755 Lisbon earthquake. Site effects are evaluated by means of a properly designed equivalent stochastic non-linear one-dimensional ground response analyses of stratified soil profile units. The requirements of the users (e.g., engineers, local administrators) constrain the choice of the scenario that can be adopted as input for disaster scenario predictions and loss modelling; in the case of Lisbon, the maximum values of shaking were assumed as the criteria for the reference scenarios.
    Description: Published
    Description: 233-243
    Description: 3T. Storia Sismica
    Description: open
    Keywords: Simulating Earthquake Scenarios ; European LESSLOSS project ; The Case of Lisbon ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 113
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    Springer
    In:  EPIC3The Andes - Active Subduction Orogeny, Frontiers in Earth Sciences, Springer, pp. 3-27, ISBN: 978-3-540-24329-8
    Publication Date: 2014-04-15
    Description: We quantitatively analyse the spatial pattern of deformation partitioning and of temporal accumulation of deformation in the Central Andes (15–26° S) with the aim of identifying those mechanisms responsible for initiating and controlling Cenozoic plateau evolution in this region. Our results show that the differential velocity between upper plate velocity and oceanic plate slab rollback velocity is crucial for determining the amount and rate of shortening, as well as their lateral variability at the leading edge of the upper plate. This primary control is modulated by factors affecting the strength balance between the upper plate lithosphere and the Nazca/South American Plate interface. These factors particularly include a stage of reduced slab dip (33 to 20 Ma) that accelerated shortening and an earlier phase (45 to 33 Ma) of higher trenchward sediment flux that reduced coupling at the plate interface, resulting in slowed shortening and enhanced slab rollback. Because high sediment flux and transfer of convergence into upper plate shortening constitute a negative feedback, we suggest that interruption of this feedback is critical for sustaining high shortening transfer, as observed for the Andes. Although we show that climate trends have no influence on the evolution of the Central Andes, the position of this region in the global arid belt in a low erosion regime is the key that provides this interruption; it inhibits high sediment flux into the trench despite the formation of relief from ongoing shortening. Along-strike variations in Andean shortening are clearly related to changes of the above factors. The spatial pattern of distribution of deformation in the Central Andes, as well as the synchronization of fault systems and the total magnitude of shortening, was mainly controlled by large-scale, inherited upper plate features that constitute zones of weakness in the upper plate leading edge. In summary, only a very particular combination of parameters appears to be able to trigger plateau-style deformation at a convergent continental margin. The combination of these parameters (in particular, differential trench-upper plate velocity evolution, high plate interface coupling from low trench infill, and the lateral distribution of weak zones in the upper plate leading edge) was highly uncommon during the Phanerozoic. This led to very few plateau-style orogens at convergent margins like the Cenozoic Central Andes in South America or, possibly, the Laramide North American Cordillera.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Inbook , peerRev
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  • 114
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    Springer
    In:  EPIC3Naturwissenschaften, Springer, 71(12), pp. 599-608, ISSN: 0028-1042
    Publication Date: 2014-06-04
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , notRev
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  • 115
    Publication Date: 2021-05-19
    Description: Metal concentrations of 37 soil samples taken from mining areas (abandoned mine pits and transport routes) in Kpogamé and Hahotoé (southern Togo) range from 0.2-43 ppm for Cd, 15-115 ppm for Pb, 182-1,029 ppm for Cr, 18-356 ppm for Cu, 15-342 pm for Ni, 90-513 ppm for V, 35-536 ppm for Zn, 80-469 ppm for Zr and 266-3,161 ppm for Sr. The tropical alteration of the ore waste plays an important role in the distribution of trace elements in the studied soils. Because the alteration affects the element mobility, generally old abandoned mining areas, which , together with soils near the transport routes, show a higher degree of contamination. Under low pH and oxidising conditions in studied soils Cd, Ni and Zn are generally easily mobilised and are thus available to the environment.
    Description: Published
    Keywords: Heavy metals ; Pollution ; Heavy metals ; Mining ; Phosphorite ; Pollution
    Repository Name: AquaDocs
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  • 116
    Publication Date: 2022-05-25
    Description: © 2008 The Author. This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License. The definitive version was published in Environmental Fluid Mechanics 8 (2008): 551-560, doi:10.1007/s10652-008-9076-5.
    Description: Experiments are reviewed in which a two-layer salt-stratified tank of water was mixed by turbulence. The density profile began as a single step and evolved to a smooth mixed profile. The turbulence was generated by many excursions of a horizontally moving vertical rod with Richardson number Ri 〉 0.9 and Reynolds Number Re 〉 600. There was almost perfect collapse of all the profiles to one universal profile as a function of a similarity variable. We develop a theoretical model for a simple mixing law with a buoyancy flux that is a function of internal Richardson number Rii. A similarity equation is found. A flux law that increases with small Rii and decreases with large Rii is considered next. Since no analytical solution is known, the similarity concept is tested by numerically integrating the equations in space and time. With buoyancy flux monotonically increasing with internal Richardson number, the similarity approach is valid for a profile starting from a slightly smoothed step. However, a shock forms for a mixing law with higher initial Rii (so that buoyancy flux decreases with Richardson number) and the similarity approach is invalid for those initial conditions.
    Keywords: Turbulence ; Mixing ; Stratified ; Similarity solution ; Layered fluid
    Repository Name: Woods Hole Open Access Server
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  • 117
    Publication Date: 2022-05-25
    Description: Author Posting. © Annual Reviews, 2003. This article is posted here by permission of Annual Reviews for personal use, not for redistribution. The definitive version was published in Annual Review of Environment and Resources 28 (2003): 521-558, doi:10.1146/annurev.energy.28.011503.163443.
    Description: Agriculture and industrial development have led to inadvertent changes in the natural carbon cycle. As a consequence, concentrations of carbon dioxide and other greenhouse gases have increased in the atmosphere and may lead to changes in climate. The current challenge facing society is to develop options for future management of the carbon cycle. A variety of approaches has been suggested: direct reduction of emissions, deliberate manipulation of the natural carbon cycle to enhance sequestration, and capture and isolation of carbon from fossil fuel use. Policy development to date has laid out some of the general principles to which carbon management should adhere. These are summarized as: how much carbon is stored, by what means, and for how long. To successfully manage carbon for climate purposes requires increased understanding of carbon cycle dynamics and improvement in the scientific capabilities available for measurement as well as for policy needs. The specific needs for scientific information to underpin carbon cycle management decisions are not yet broadly known. A stronger dialogue between decision makers and scientists must be developed to foster improved application of scientific knowledge to decisions. This review focuses on the current knowledge of the carbon cycle, carbon measurement capabilities (with an emphasis on the continental scale) and the relevance of carbon cycle science to carbon sequestration goals.
    Description: The National Center for Atmospheric Research is supported by the National Science Foundation.
    Keywords: Carbon sequestration ; Measurement techniques ; Climate ; Kyoto protocol
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 118
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    Annual Reviews
    Publication Date: 2022-05-25
    Description: Author Posting. © Annual Reviews, 2006. This article is posted here by permission of Annual Reviews for personal use, not for redistribution. The definitive version was published in Annual Review of Fluid Mechanics 38 (2006): 395-425, doi:10.1146/annurev.fluid.38.050304.092129.
    Description: Over the past four decades, the combination of in situ and remote sensing observations has demonstrated that long nonlinear internal solitary-like waves are ubiquitous features of coastal oceans. The following provides an overview of the properties of steady internal solitary waves and the transient processes of wave generation and evolution, primarily from the point of view of weakly nonlinear theory, of which the Korteweg-de Vries equation is the most frequently used example. However, the oceanographically important processes of wave instability and breaking, generally inaccessible with these models, are also discussed. Furthermore, observations often show strongly nonlinear waves whose properties can only be explained with fully nonlinear models.
    Description: KRH acknowledges support from NSF and ONR and an Independent Study Award from the Woods Hole Oceanographic Institution. WKM acknowledges support from NSF and ONR, which has made his work in this area possible, in close collaboration with former graduate students at Scripps Institution of Oceanography and MIT.
    Keywords: Solitary waves ; Nonlinear waves ; Stratified flow ; Physical Oceanography
    Repository Name: Woods Hole Open Access Server
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  • 119
    Publication Date: 2022-05-25
    Description: This paper is not subject to U.S. copyright. The definitive version was published in Geo-Marine Letters 29 (2009): 395-404, doi:10.1007/s00367-009-0159-1.
    Description: A program of geophysical mapping and vibracoring was conducted to better understand the geologic evolution of Apalachicola Bay. Analyses of the geophysical data and sediment cores along with age control provided by 34 AMS 14C dates on marine shells and wood reveal the following history. As sea level rose in the early Holocene, fluvial deposits filled the Apalachicola River paleochannel, which extended southward under the central part of the bay and seaward across the continental shelf. Sediments to either side of the paleochannel contain abundant wood fragments, with dates documenting that those areas were forested at 8,000 14C years b.p. As sea level continued to rise, spits formed of headland prodelta deposits. Between ~6,400 and ~2,500 14C years b.p., an Apalachicola prodelta prograded and receded several times across the inner shelf that underlies the western part of the bay. An eastern deltaic lobe was active for a shorter time, between ~5,800 and 5,100 14C years b.p. Estuarine benthic foraminiferal assemblages occurred in the western bay as early as 6,400 14C years b.p., and indicate that there was some physical barrier to open-ocean circulation and shelf species established by that time. It is considered that shoals formed in the region of the present barrier islands as the rising sea flooded an interstream divide. Estuarine conditions were established very early in the post-glacial flooding of the bay.
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  • 120
    Publication Date: 2022-05-25
    Description: © 2009 The Authors. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License. The definitive version was published in Marine Biology 156 (2009): 1049-1056, doi:10.1007/s00227-009-1149-6.
    Description: Behavioral observations using a remotely operated vehicle (ROV) in the Gulf of California in March, 2003, provided insights into the vertical distribution, feeding and anatomy of the rare and delicate ctenophore Thalassocalyce inconstans. Additional archived ROV video records from the Monterey Bay Aquarium Research Institute of 288 sightings of T. inconstans and 2,437 individual observations of euphausiids in the Gulf of California and Monterey Canyon between 1989 and 2005 were examined to determine ctenophore and euphausiid prey depth distributions with respect to temperature and dissolved oxygen concentration [dO]. In the Gulf of California most ctenophores (96.9%) were above 350 m, the top of the oxygen minimum layer. In Monterey Canyon the ctenophores were more widely distributed throughout the water column, including the hypoxic zone, to depths as great as 3,500 m. Computer-aided behavioral analysis of two video records of the capture of euphausiids by T. inconstans showed that the ctenophore contracted its bell almost instantly (0.5 s), transforming its flattened, hemispherical resting shape into a closed bi-lobed globe in which seawater and prey were engulfed. Euphausiids entrapped within the globe displayed a previously undescribed escape response for krill (‘probing behavior’), in which they hovered and gently probed the inner surfaces of the globe with antennae without stimulating further contraction by the ctenophore. Such rapid bell contraction could be effected only by a peripheral sphincter muscle even though the presence of circumferential ring musculature was unknown for the Phylum Ctenophora. Thereafter, several live T. inconstans were collected by hand off Barbados and microscopic observations confirmed that assumption.
    Description: Supported by the David and Lucile Packard Foundation and NOAA Grant #NA06OAR4600091.
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  • 121
    Publication Date: 2022-05-25
    Description: © 2008 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License. The definitive version was published in Environmental Fluid Mechanics 8 (2008): 495-509, doi:10.1007/s10652-008-9107-2.
    Description: Estuarine turbulence is notable in that both the dissipation rate and the buoyancy frequency extend to much higher values than in other natural environments. The high dissipation rates lead to a distinct inertial subrange in the velocity and scalar spectra, which can be exploited for quantifying the turbulence quantities. However, high buoyancy frequencies lead to small Ozmidov scales, which require high sampling rates and small spatial aperture to resolve the turbulent fluxes. A set of observations in a highly stratified estuary demonstrate the effectiveness of a vessel-mounted turbulence array for resolving turbulent processes, and for relating the turbulence to the forcing by the Reynolds-averaged flow. The observations focus on the ebb, when most of the buoyancy flux occurs. Three stages of mixing are observed: (1) intermittent and localized but intense shear instability during the early ebb; (2) continuous and relatively homogeneous shear-induced mixing during the mid-ebb, and weakly stratified, boundary-layer mixing during the late ebb. The mixing efficiency as quantified by the flux Richardson number Rf was frequently observed to be higher than the canonical value of 0.15 from Osborn (J Phys Oceanogr 10:83–89, 1980). The high efficiency may be linked to the temporal–spatial evolution of shear instabilities.
    Description: The funding for this research was obtained from ONR Grant N00014-06-1-0292 and NSF Grant OCE-0729547.
    Keywords: Turbulence ; Estuaries ; Shear instability ; Buoyancy flux
    Repository Name: Woods Hole Open Access Server
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  • 122
    Publication Date: 2022-05-25
    Description: © 2009 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License. The definitive version was published in JARO - Journal of the Association for Research in Otolaryngology 10 (2009): 497-509, doi:10.1007/s10162-009-0174-y.
    Description: The dynamic displacement of the semicircular canal cupula and modulation of afferent nerve discharge were measured simultaneously in response to physiological stimuli in vivo. The adaptation time constant(s) of normal cupulae in response to step stimuli averaged 36 s, corresponding to a mechanical lower corner frequency for sinusoidal stimuli of 0.0044 Hz. For stimuli equivalent to 40–200 deg/s of angular head velocity, the displacement gain of the central region of the cupula averaged 53 nm per deg/s. Afferents adapted more rapidly than the cupula, demonstrating the presence of a relaxation process that contributes significantly to the neural representation of angular head motions by the discharge patterns of canal afferent neurons. We also investigated changes in time constants of the cupula and afferents following detachment of the cupula at its apex—mechanical detachment that occurs in response to excessive transcupular endolymph pressure. Detached cupulae exhibited sharply reduced adaptation time constants (300 ms–3 s, n = 3) and can be explained by endolymph flowing rapidly over the apex of the cupula. Partially detached cupulae reattached and normal afferent discharge patterns were recovered 5–7 h following detachment. This regeneration process may have relevance to the recovery of semicircular canal function following head trauma.
    Description: Financial support was provided by the NIDCD R01 DC06685 (Rabbitt) and NASA GSRP 56000135 & NSF IGERT DGE- 9987616 (Breneman).
    Keywords: Vestibular ; Inner ear micromechanics ; Cupula regeneration ; Angular motion sensation ; Afferent response dynamics
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  • 123
    Publication Date: 2022-05-25
    Description: First published online as a Review in Advance on October 24, 2005. (Some corrections may occur before final publication online and in print)
    Description: Author Posting. © Annual Reviews, 2005. This article is posted here by permission of Annual Reviews for personal use, not for redistribution. The definitive version was published in Annual Review of Physiology 68 (2006): 22.1-22.29, doi:10.1146/annurev.physiol.68.040104.105418.
    Description: Superfast muscles of vertebrates power sound production. The fastest, the swimbladder muscle of toadfish, generates mechanical power at frequencies in excess of 200 Hz. To operate at these frequencies, the speed of relaxation has had to increase approximately 50-fold. This increase is accomplished by modifications of three kinetic traits: (a) a fast calcium transient due to extremely high concentration of sarcoplasmic reticulum (SR)-Ca2+ pumps and parvalbumin, (b) fast off-rate of Ca2+ from troponin C due to an alteration in troponin, and (c) fast cross-bridge detachment rate constant (g, 50 times faster than that in rabbit fast-twitch muscle) due to an alteration in myosin. Although these three modifications permit swimbladder muscle to generate mechanical work at high frequencies (where locomotor muscles cannot), it comes with a cost: The high g causes a large reduction in attached force-generating cross-bridges, making the swimbladder incapable of powering low-frequency locomotory movements. Hence the locomotory and sound-producing muscles have mutually exclusive designs.
    Description: This work was made possible by support from NIH grants AR38404 and AR46125 as well as the University of Pennsylvania Research Foundation.
    Keywords: Parvalbumin ; Ca2+ release ; Ca2+ uptake ; Cross-bridges ; Adaptation ; Sound production ; Whitman Center
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  • 124
    Publication Date: 2022-02-16
    Description: The role of mud volcanoes (MVs) as a source of methane(CH4) flux to the atmosphere and the ocean has been increasingly recognised in the last several years (Milkov 2000; Dimitrov 2002, 2003; Etiope and Klusman 2002; Kopf 2002, 2003; Milkov et al. 2003; Etiope and Milkov 2004). In one of the most recent papers, Kopf (2003) claims to report a reliable estimate of the global CH4 emission from MVs. However, the significance and usefulness of the estimate presented by Kopf (2003) are rather poor. The used dataset is smaller than in previous studies (although the author makes a reverse claim), and some previously published works are misquoted and misinterpreted. Numerous arithmetic mistakes made during simple calculations and data manipulations lead to confusing results and conclusions. In this comment, we highlight some of the most significant problems with the estimates published by Kopf (2003).
    Description: Published
    Description: 490-492
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: reserved
    Keywords: Methane ; mud volcanoes ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 125
    Publication Date: 2022-02-16
    Description: A new estimate of global methane emission into the atmosphere from mud volcanoes (MVs) on land and shallow seafloor is presented. The estimate, considered a lower limit, is based on 1) new direct measurements of flux, including both venting of methane and diffuse microseepage around craters and vents, and 2) a classification of MV sizes in terms of area (km2) based on a compilation of data from 120 MVs. The methane flux to the atmosphere is conservatively estimated between 6 and 9 Mt y)1. This emission from MVs is 3–6% of the natural methane sources and is comparable with ocean and hydrate sources, officially considered in the atmospheric methane budget. The total geologic source, including MVs, seepage from seafloor, microseepage in hydrocarbon-prone areas and geothermal sources, would amount to 35–45 Mt y)1. The authors believe it is time to add this parameter in the Intergovernmental Panel on Climate Change official tables of atmospheric methane sources.
    Description: Published
    Description: 997-1002
    Description: 4.5. Degassamento naturale
    Description: JCR Journal
    Description: reserved
    Keywords: Methane ; Mud volcanoes ; 03. Hydrosphere::03.04. Chemical and biological::03.04.05. Gases
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 126
    Publication Date: 2022-06-09
    Description: Results of geological, geomechanical and seismometric investigations aiming at the analysis of the seismic response in a carbonate ridge of the Nera River valley (Central Apennines – Italy) are discussed. Geological and geomechanical surveys were aimed at defining the stratigraphic and structural setting of the outcropping formations and the jointing conditions of the rock mass. Velocimetric records of both ambient noise and small-magnitude earthquakes were analysed in order to identify amplification conditions. The analysis was carried out in the time domain, through directional energy evaluation, and in the frequency domain, through H/V spectral ratios and spectral ratios with respect to a reference station. A local amplification factor was estimated from Housner intensity. The study revealed a significant seismic amplification in a fault zone. This effect was observed in intensely jointed and mylonitic rock masses, located inside moderately jointed rock masses, and is the result of specific geometries and significant impedance contrasts. A map of fault zones prone to amplification of ground motion was constructed, taking into account the jointing conditions of the rock masses and the structural setting of the investigated ridge. The study relied on an integrated methodological approach, which combined the available data under union and intersection criteria.
    Description: Published
    Description: 416-449
    Description: JCR Journal
    Description: reserved
    Keywords: jointed rock masses ; velocimetric records ; seismic amplification ; trapped waves ; Central Italy ; 04. Solid Earth::04.06. Seismology::04.06.09. Waves and wave analysis
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  • 127
    Publication Date: 2022-05-24
    Description: Various authors, analysing the set of accelerograms recorded at Gubbio Piana (GBP) (central Italy), have demonstrated that strong amplification occurs at this accelerometric station, which is installed within an alluvial basin. In particular, Ambraseys et al. [(2005a), Bull Earthq Eng 3:1–53; (2005b), Bull Earth Eng 3:55–73] observed that the strong motion peaks at GBP greatly exceed the median values predicted by the attenuation relationships they derived for Europe. In this work, we analyse and discuss some characteristics of the ground motion recorded at the GBP station. We show that the ground motion parameters, such as peak-ground acceleration and peak-ground velocity, are strongly influenced by the presence of locally induced surface waves that produce both a lengthening of the significant shaking duration and an increase in the peak values with respect to a nearby bedrock site. The basin-induced surface waves are observed in the three components of motion and their effects on the peak values are particularly evident in the vertical component. In the frequency domain, the energy of the surface waves is mostly restricted to the frequency band 0.4–0.8Hz for both the horizontal and vertical components. The horizontal and vertical Fourier amplitudes are also very similar, and this indicates that the H/V spectral ratio technique is not applicable to describing the site response due to the propagation of seismic wave in a complex 2D/3D geological structure. Finally, a preliminary polarization analysis shows that the directions of polarization, as well as the degree of elliptical polarization, exhibit a strong variability with time, that may be related to a complex propagation of Love and Rayleigh waves within the basin.
    Description: Published
    Description: JCR Journal
    Description: reserved
    Keywords: Strong motion ; Alluvial basin effects ; Site effects ; Gubbio plain ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion
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  • 128
    Publication Date: 2022-05-30
    Description: Scientific investigations in Antarctica are, for many different reasons, a challenging and fascinating task. Measurements, observations and field operations must be carefully planned well in advance and the capacity of successfully meeting the goals of a scientific project is often related to the capacity of forecasting and anticipating the many different potential mishaps. In order to do that, experience and logistic support are crucial. On the scientific side, the team must be aware of its tasks and be prepared to carry out observations in a hostile environment: both technology and human resources have to be suitably selected, prepared, tested and trained. On the logistic side, nations, institutions and any other organisation involved in the expeditions must ensure the proper amount of competence and practical support. The history of modern Italian Antarctic expeditions dates back to the middle 80’s when the first infrastructures of “Mario Zucchelli Station”, formerly Terra Nova Bay Station, were settled at Terra Nova Bay, Northern Victoria Land. Only a few years later, the first geodetic infrastructures were planned and built. Italian geodetic facilities and activities were, ever since, being constantly maintained and developed. Nowadays, the most remarkable geodetic infrastructures are the permanent Global Positioning System (GPS) station (TNB1) installed at Mario Zucchelli and the GPS geodetic network Victoria Land Network for DEFormation control (VLNDEF) entirely deployed on an area extending between 71° S and 76° S and 160° E and 170° E. These facilities do not only allow carrying out utmost geodetic investigations but also posses interesting capacities on the international multidisciplinary scientific scenario. In order to fully exploit their potentiality, management and maintenance of the infrastructure are crucial; nevertheless, in order to perform high quality scientific research, these abilities must be coupled with the knowledge concerning a proper use and a correct processing of the information that these infrastructures can provide. This work focuses on the different methods that can be applied to process the observations that are performed with GPS technique in Northern Victoria Land, aiming at reaching the highest accuracy of results and assuring the larger significance and versatility of the processing outcomes. Three software were used for the analysis, namely: Bernese v.5.0, Gipsy/Oasis II and Gamit/Globk. The working data sets are (i) the permanent GPS station TNB1 observations continuously performed since 1998 and (ii) the five episodic campaigns performed on the sites of VLNDEF. The two infrastructures can be regarded as neat examples of standard geodetic installation in Antarctica. Therefore, the technological solutions that were adopted and applied for establishing the GPS permanent station and the VLNDEF geodetic network as well as the data processing strategies and the data analysis procedures that were tested on their observation will be illustrated in detail. The results will be presented, compared and discussed. Furthermore, their potentials and role in geodetic research will be carefully described; their versatility will also be highlighted in the foreground of a multidisciplinary Antarctic international scientific activity.
    Description: Published
    Description: 37-72
    Description: 1.8. Osservazioni di geofisica ambientale
    Description: reserved
    Keywords: Antarctica ; Geodesy ; Geodetic Infrastructures ; GPS ; 01. Atmosphere::01.01. Atmosphere::01.01.08. Instruments and techniques
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 129
    Publication Date: 2022-05-24
    Description: In the framework of the SESAME project one of the taskswas the compilation of all available ambient noise measurements within urban environments affected by historical or/and recent strong earthquakes in Europe. The aim of such a task was to give an answer to the question; “How does horizontal-to-vertical ambient noise spectral ratio compare with damage in modern cities?”. For this purpose five European urban areas, namely, Angra do Heroismo (Portugal), Fabriano and Palermo (Italy), Thessaloniki and Kalamata (Greece) were selected for which spatial damage information was available either in terms of modified Mercalli intensity or in EMS98 damage grades. The geological setting of the examined sites as well as the causative earthquakes are satisfactorily known. Ambient noise recordings compiled for all examined sites have been homogeneously processed by a technique developed and agreed upon SESAME project. Using a standard multivariate statistical analysis, namely, factor analysis and canonical correlation, the horizontal-to-vertical ambient noise spectral ratio (HVNSR) is correlated with damage pattern observed within examined urban areas. Results show that, in some cases (Thessaloniki, Palermo), the HVNSR seems to be able to differentiate between areas previously shown to be associated with higher damage. In other cases however (Angra do Heroismo, Fabriano, Kalamata), the correlation is not statistically significant indicating thus the complex character of the parameters involved, implying that currently there is no a straightforward way that a value of HVNSR can correctly predict the extent to which a given region will be associated with increased damage.
    Description: Published
    Description: 109–140
    Description: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Description: JCR Journal
    Description: reserved
    Keywords: Ambient noise ; Site effect ; Macroseismic intensity ; Factor and canonical analysis ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous
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  • 130
    Publication Date: 2022-05-24
    Description: The concerted effort to collect earthquake damage data in Italy over the past 30 years has led to the development of an extensive database from which vulnerability predictions for the Italian building stock can be derived. A methodology to derive empirical vulnerability curves with the aforementioned data is presented herein and the resulting curves have been directly compared with mechanics-based vulnerability curves. However, it has been found that a valid comparison between the empirical and analytical vulnerability curves is not possible mainly due to a number of shortcomings in the database of surveyed buildings. A detailed discussion of the difficulties in deriving vulnerability curves from the current observed damage database is thus also presented.
    Description: DPC — Dipartimento della Protezione Civile MIUR – Ministero dell’Università e della Ricerca - project AIRPLANE
    Description: Published
    Description: 485–504
    Description: 4.2. TTC - Scenari e mappe di pericolosità sismica
    Description: JCR Journal
    Description: reserved
    Keywords: vulnerability curves ; damage data ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 131
    Publication Date: 2022-05-26
    Description: © 2009 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License. The definitive version was published in Coral Reefs 28 (2009): 327-337, doi:10.1007/s00338-009-0466-z.
    Description: Design and decision-making for marine protected areas (MPAs) on coral reefs require prediction of MPA effects with population models. Modeling of MPAs has shown how the persistence of metapopulations in systems of MPAs depends on the size and spacing of MPAs, and levels of fishing outside the MPAs. However, the pattern of demographic connectivity produced by larval dispersal is a key uncertainty in those modeling studies. The information required to assess population persistence is a dispersal matrix containing the fraction of larvae traveling to each location from each location, not just the current number of larvae exchanged among locations. Recent metapopulation modeling research with hypothetical dispersal matrices has shown how the spatial scale of dispersal, degree of advection versus diffusion, total larval output, and temporal and spatial variability in dispersal influence population persistence. Recent empirical studies using population genetics, parentage analysis, and geochemical and artificial marks in calcified structures have improved the understanding of dispersal. However, many such studies report current self-recruitment (locally produced settlement/settlement from elsewhere), which is not as directly useful as local retention (locally produced settlement/total locally released), which is a component of the dispersal matrix. Modeling of biophysical circulation with larval particle tracking can provide the required elements of dispersal matrices and assess their sensitivity to flows and larval behavior, but it requires more assumptions than direct empirical methods. To make rapid progress in understanding the scales and patterns of connectivity, greater communication between empiricists and population modelers will be needed. Empiricists need to focus more on identifying the characteristics of the dispersal matrix, while population modelers need to track and assimilate evolving empirical results.
    Description: Work by CB Paris was supported by the National Science Foundation grant NSF-OCE 0550732. Work by M-A Coffroth and SR Thorrold was supported by the National Science Foundation grant NSF-OCE 0424688. Work by TL Shearer was supported by an International Cooperative Biodiversity Group grant R21 TW006662-01 from the Fogarty International Center at the National Institutes of Health.
    Keywords: Connectivity ; Larval dispersal ; Marine protected areas ; Resilience ; Replacement ; Genetics
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  • 132
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    In:  Primate Biogeography, Progress and Prospects vol. 77 no. 2, pp. 135-138
    Publication Date: 2024-01-12
    Keywords: primates ; biogeography
    Repository Name: National Museum of Natural History, Netherlands
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  • 133
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    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
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  • 134
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
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  • 135
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    In:  International Association of Geodesy Symposia
    Publication Date: 2020-02-12
    Description: The lAG International Symposium on Gravity, Geoid, and Space Missions 2004 (GGSM2004) was lield in the beautiful city of Porto, Portugal, from 30 August to 3 September 2004. This symposium encompassed the themes of Commission 2 (Gravity Field) of the newly structured lAG, as well as interdisciplinary topics related to geoid and gravity modeling, with special attention given to the current and planned gravi- dedicated satellite missions. The symposium also followed in the tradition of mid-term meetings that were held between the quadrennial joint meetings of the International Geoid and Gravity Commissions. The previous mid-term meetings were the International Symposia on Gravity, Geoid, and Marine Geodesy (Tokyo, 1996), and Gravity, Geoid, and Geodynamics (Banff, 2000). GGSM2004 aimed to bring together scientists from different areas in the geosciences, working with gravity and geoid related problems, both from the theoretical and practical points of view. Topics of interest included the integration of heterogeneous data and contributions from satellite and airborne techniques to the study of the spatial and temporal variations of the gravity field. In addition to the special focus on the CHAMP, GRACE, and GOCE satellite missions, attention was also directed toward projects addressing topographic and ice field mapping using SAR, LIDAR, and laser altimetry, as well as missions and studies related to planetary geodesy.
    Language: English
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  • 136
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  • 137
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
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  • 138
    Publication Date: 2020-02-12
    Keywords: 550 - Earth sciences
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  • 139
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  • 140
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    Publication Date: 2020-02-12
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  • 141
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  • 142
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 14 (1996), S. 301-331 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Precise regulation of major histocompatibility complex class II (MHC-II) gene expression plays a crucial role in the control of the immune response. A major breakthrough in the elucidation of the molecular mechanisms involved in MHC-II regulation has recently come from the study of patients that suffer from a primary immunodeficiency resulting from regulatory defects in MHC-II expression. A genetic complementation cloning approach has led to the isolation of CIITA and RFX5, two essential MHC-II gene transactivators. CIITA and RFX5 are mutated in these patients, and the wild-type genes are capable of correcting their defect in MHC-II expression. The identification of these regulatory factors has furthered our understanding of the molecular mechanisms that regulate MHC-II genes. CIITA was found to be a non-DNA binding transactivator that functions as a molecular switch controlling both constitutive and inducible MHC-II expression. The finding that RFX5 is a subunit of the nuclear RFX-complex has confirmed that a deficiency in the binding of this complex is indeed the molecular basis for MHC-II deficiency in the majority of patients. Furthermore, the study of RFX has demonstrated that MHC-II promoter activity is dependent on the binding of higher-order complexes that are formed by highly specific cooperative binding interactions between certain MHC-II promoter-binding proteins. Two of these proteins belong to families of which the other members, although capable of binding to the same DNA motifs, are probably not directly involved in the control of MHC-II expression. Finally, the facts that CIITA and RFX5 are both essential and highly specific for MHC-II genes make possible novel strategies designed to achieve immunomodulation via transcriptional intervention.
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  • 143
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 14 (1996), S. 397-440 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNFalpha, IL-1, IL-6, GM-CSF, and chemokines such as IL-8 are abundant in all patients regardless of therapy. This is compensated to some degree by the increased production of anti-inflammatory cytokines such as IL-10 and TGFbeta and cytokine inhibitors such as IL-1ra and soluble TNF-R. However, this upregulation in homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the TNFalpha and IL-1 produced. In rheumatoid joint cell cultures that spontaneously produce IL-1, TNFalpha was the major dominant regulator of IL-1. Subsequently, other proinflammatory cytokines were also inhibited if TNFalpha was neutralized, leading to the new concept that the proinflammatory cytokines were linked in a network with TNFalpha at its apex. This led to the hypothesis that TNFalpha was of major importance in rheumatoid arthritis and was a therapeutic target. This hypothesis has been successfully tested in animal models, of, for example, collagen-induced arthritis, and these studies have provided the rationale for clinical trials of anti-TNFalpha therapy in patients with long-standing rheumatoid arthritis. Several clinical trials using a chimeric anti-TNFalpha antibody have shown marked clinical benefit, verifying the hypothesis that TNFalpha is of major importance in rheumatoid arthritis. Retreatment studies have also shown benefit in repeated relapses, indicating that the disease remains TNFalpha dependent. Overall these studies demonstrate that analysis of cytokine expression and regulation may yield effective therapeutic targets in inflammatory disease.
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  • 144
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    Annual Review of Immunology 14 (1996), S. 511-532 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract In contrast with the study of alphabeta T cells, that of gammadelta T cells is relatively recent and stems from the discovery of their rearranged genes, rather than from any knowledge of their biological function. Thus, experiments designed to characterize their specificity and function have drawn heavily on our knowledge of alphabeta T cells. During the past few years, many studies, especially with mice lacking either alphabeta or gammadelta T cells, have demonstrated that gammadelta T cells can contribute to immune competence, but they do so in a way that is distinct from alphabeta T cells. It is also evident that gammadelta T cells may not recognize antigen the same way as do alphabeta T cells. Analysis of three protein antigens-the murine MHC class II IEk, the nonclassical MHC T10/T22, and the Herpes virus glycoprotein gI-indicates that gammadelta T cell recognition does not require antigen processing and that the proteins are recognized directly. In all three cases, recognition by these T cell clones involves neither peptides bound to these proteins nor peptides derived from them. Moreover, a group of small phosphate-containing nonpeptide compounds derived from mycobacterial extracts has been found to stimulate a major population of human peripheral gammadelta T cells in a T cell receptor (TCR)-dependent manner. This indicates that gammadelta T cells can respond to ligands that are different from those of alphabeta T cells. Analysis of complementarity determining region (CDR3) length distributions of gamma and delta chains indicates that they are more similar to those of immunoglobulins than to TCR alpha and beta. This further supports the idea that gammadelta and alphabeta T cells recognize antigens differently and suggests that gammadelta T cells may be more like immunoglobulins in their recognition properties. gammadelta T cells share many cell surface proteins with alphabeta T cells and are able to secrete lymphokines and express cytolytic activities in response to antigenic stimulation. These, together with the results cited above, indicate that gammadelta T cells can mediate cellular immune functions without a requirement for antigen processing. Thus, pathogens, damaged tissues, or even B and T cells can be recognized directly, and cellular immune responses can be initiated without a requirement for antigen degradation or specialized antigen-presenting cells. This would give gammadelta T cells greater flexibility than the more classical type of alphabeta T cell-mediated cellular immunity.
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    Annual Review of Immunology 14 (1996), S. 649-681 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The transcription factor NF-kappaB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases. A primary level of control for NF-kappaB is through interactions with an inhibitor protein called IkappaB. Recent evidence confirms the existence of multiple forms of IkappaB that appear to regulate NF-kappaB by distinct mechanisms. NF-kappaB can be activated by exposure of cells to LPS or inflammatory cytokines such as TNF or IL-1, viral infection or expression of certain viral gene products, UV irradiation, B or T cell activation, and by other physiological and nonphysiological stimuli. Activation of NF-kappaB to move into the nucleus is controlled by the targeted phosphorylation and subsequent degradation of IkappaB. Exciting new research has elaborated several important and unexpected findings that explain mechanisms involved in the activation of NF-kappaB. In the nucleus, NF-kappaB dimers bind to target DNA elements and activate transcription of genes encoding proteins involved with immune or inflammation responses and with cell growth control. Recent data provide evidence that NF-kappaB is constitutively active in several cell types, potentially playing unexpected roles in regulation of gene expression. In addition to advances in describing the mechanisms of NF-kappaB activation, excitement in NF-kappaB research has been generated by the first report of a crystal structure for one form of NF-kappaB, the first gene knockout studies for different forms of NF-kappaB and of IkappaB, and the implications for therapies of diseases thought to involve the inappropriate activation of NF-kappaB.
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    Annual Review of Immunology 15 (1997), S. 93-124 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis complements the information provided by the generation of genetic defects in mice created using homologous recombination techniques. In this review, the recent findings made in three areas are focused upon deficiencies in T cell differentiation and in T lymphocyte activation, and on the control process of peripheral immune response.
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    Annual Review of Immunology 15 (1997), S. 203-234 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract This review deals with membrane Fc receptors (FcR) of the immunoglobulin superfamily. It is focused on the mechanisms by which FcR trigger and regulate biological responses of cells on which they are expressed. FcR deliver signals when they are aggregated at the cell surface. The aggregation of FcR having immunoreceptor tyrosine-based activation motifs (ITAMs) activates sequentially src family tyrosine kinases and syk family tyrosine kinases that connect transduced signals to common activation pathways shared with other receptors. FcR with ITAMs elicit cell activation, endocytosis, and phagocytosis. The nature of responses depends primarily on the cell type. The aggregation of FcR without ITAM does not trigger cell activation. Most of these FcR internalize their ligands, which can be endocytosed, phagocytosed, or transcytosed. The fate of internalized receptor-ligand complexes depends on defined sequences in the intracytoplasmic domain of the receptors. The coaggregation of different FcR results in positive or negative cooperation. Some FcR without ITAM use FcR with ITAM as signal transduction subunits. The coaggregation of antigen receptors or of FcR having ITAMs with FcR having immunoreceptor tyrosine-based inhibition motifs (ITIMs) negatively regulates cell activation. FcR therefore appear as the subunits of multichain receptors whose constitution is not predetermined and which deliver adaptative messages as a function of the environment.
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    Annual Review of Immunology 15 (1997), S. 297-322 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract T helper lymphocytes can be divided into two distinct subsets of effector cells based on their functional capabilities and the profile of cytokines they produce. The Th1 subset of CD4+ T cells secretes cytokines usually associated with inflammation, such as IFN-gamma and TNF and induces cell-mediated immune responses. The Th2 subset produces cytokines such as IL-4 and IL-5 that help B cells to proliferate and differentiate and is associated with humoral-type immune responses. The selective differentiation of either subset is established during priming and can be significantly influenced by a variety of factors. One of these factors, the cytokine environment, has been put forward as the major variable influencing Th development and is already well reviewed by others. Instead, in the current review, we focus on some of the alternative approaches for skewing Th1/Th2 responses. Specifically, we discuss the effects on Th priming of (a) using altered peptide ligands as antigens, (b) varying the dose of antigen, and (c) altering costimulatory signals. The potential importance of each of these variables to influence immune responses to pathogens in vivo is discussed throughout.
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    Annual Review of Immunology 15 (1997), S. 405-431 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Epstein-Barr virus (EBV) provides one of the most informative systems with which to study cytotoxic T lymphocyte (CTL) responses in humans. The virus establishes a highly immunogenic growth-transforming infection of B lymphocytes, associated with the coordinate expression of six virus-coded nuclear antigens (EBNAs 1, 2, 3A, 3B, 3C, -LP) and two latent membrane proteins (LMPs 1 and 2). This elicits both primary and memory CT8+ CTL responses that are markedly skewed toward HLA allele-specific epitopes drawn from the EBNA3A, 3B, 3C subset of latent proteins, with reactivities to other antigens being generally much less frequent. This heirarchy of immunodominance among the different latent proteins may at least partly reflect their differential accessibility to the HLA class I-processing pathway. Furthermore, CTLs to some of the immunodominant epitopes involve highly conserved T cell receptor (TCR) usage, a level of focusing which evidence suggests could have immunopathological consequences from cross-reactive recognition of other target structures. EBV is associated with a range of human tumors, and there is increasing interest in the possibility of targeting such malignancies using virus-specific CTLs. The dramatic reversal of EBV-driven lymphoproliferations in bone marrow transplant patients following CTL infusion demonstrates the potential of this approach, and here we discuss prospects for its extension to other EBV-positive tumors in which the immunodominant EBNA3A, 3B, 3C proteins are not expressed.
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    Annual Review of Immunology 15 (1997), S. 535-562 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract NK1 T cells are a specialized population of alpha/beta T cells that coexpress receptors of the NK lineage and have the unique potential to very rapidly secrete large amounts of cytokines, providing early help for effector cells and regulating the Th1 or Th2 differentiation of some immune responses. NK1 T cells express a restricted TCR repertoire made of an invariant TCR alpha chain, Valpha14-Jalpha281, associated with polyclonal Vbeta8, Vbeta7, and Vbeta2 TCR beta chains. NK1 T cells recognize the products of the conserved family of MHC class I-like CD1 genes, apparently in the absence of foreign antigens. Thus, this novel regulatory pathway, which straddles the innate and the adaptive immune systems, is unique in that its activation may not require associative recognition of antigen. Here, we review the specificity and function of mouse NK1 T cells, and we discuss the relationship of this lineage to mainstream T cells and NK cells.
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    Annual Review of Immunology 15 (1997), S. 797-819 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Receptors for most interleukins and cytokines that regulate immune and hematopoietic systems belong to the class I cytokine receptor family. These molecules form multichain receptor complexes in order to exhibit high-affinity binding to, and mediate biological functions of, their respective cytokines. In most cases, these functional receptor complexes share common signal transducing receptor components that are also in the class I cytokine receptor family, i.e. gp130, common beta, and common gamma molecules. Interleukin-6 and related cytokines, interleukin-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1 are all pleiotropic and exhibit overlapping biological functions. Functional receptor complexes for this interleukin-6 family of cytokines share gp130 as a component critical for signal transduction. Unlike cytokines sharing common beta and common gamma chains that mainly function in hematopoietic and lymphoid cell systems, the interleukin-6 family of cytokines function extensively outside these systems as well, e.g. from the cardiovascular to the nervous system, owing to ubiquitously expressed gp130. Stimulation of cells with the interleukin-6 family of cytokines triggers homo- or hetero-dimerization of gp130. Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors. This paper reviews recent progress in the study of the interleukin-6 family of cytokines and gp130.
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    Annual Review of Immunology 16 (1998), S. 1-25 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: At first one is very pleased at being invited to write a Prefatory Chapter, but as the delivery deadline draws closer one begins to think, "Oh my God! What on earth can I say that all but family members and few close friends will not find a great bore?" One solution is to write a scientific essay, but I concluded that that was a cop-out. I decided that perhaps the best tack to follow was to try to convey to the reader the personal characteristics I bring to my science and to other aspects of my professional career. The writing of this chapter has certainly convinced me that my particular background influenced what problems I chose to work on and how I approached their solution, but I hope that my results have a more ecumenical significance. There's been much written recently about how one's cultural background affects one's science, but I think that thesis can also be exaggerated. Science is a method of inquiry that by using certain guidelines permits rational individuals to observe Nature in a way that their findings will agree and have permanence. We shouldn't be diffident about defending that claim of objectivity.
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    Annual Review of Immunology 16 (1998), S. 111-135 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: Abstract CD40-CD154-mediated contact-dependent signals between B and T cells are required for the generation of thymus dependent (TD) humoral immune responses. CD40-CD154 interactions are however also important in many other cell systems. CD40 is expressed by a large variety of cell types other than B cells, and these include dendritic cells, follicular dendritic cells, monocytes, macrophages, mast cells, fibroblasts, and endothelial cells. CD40- and CD154-knockout mice and antibodies to CD40 and CD154 have helped to elucidate the role of the CD40-CD154 system in immune responses. Recently published studies indicate that CD40-CD154 interactions can influence T cell priming and T cell-mediated effector functions; they can also upregulate costimulatory molecules and activate macrophages, NK cells, and endothelia as well as participate in organ-specific autoimmune disease, graft rejection, and even atherosclerosis. This review focuses on the role of the CD40-CD154 system in the regulation of many newly discovered functions important in inflammation and cell-mediated immunity.
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    Annual Review of Immunology 16 (1998), S. 201-223 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: Abstract Immunological memory can be defined as the faster and stronger response of an animal that follows reexposure to the same antigen. By this definition, it is an operational property of the whole animal or the immune system. Memory cells express a different pattern of cell surface markers, and they respond in several ways that are functionally different from those of naive cells. Murine memory cells are CD44 high and low in the expression of activation markers such as CD25 (IL-2R), whereas human memory cells are CD45RA-, CD45RO+. In contrast to naive cells, memory cells secrete a full range of T cell cytokines and can be polarized to secrete particular restricted patterns of secretion for both CD4 and CD8 T cells. The requirements for the activation of memory cells for proliferation and cytokine production are not quite as strict as those of naive cells, but costimulation in the broad sense is required for optimum responses and for responses to suboptimum antigen concentrations. It would appear that memory cells can persist in the absence of antigenic stimulation and persist as nondividing cells. Reencounter with the same antigen can expand the population to a new, stable, higher level and generate a separate population of CD44 high effectors that may be required for protection, while competition from other antigens can drive it down to a lower stable level. It is unclear how or where memory cells arise, but once generated they have different pathways of recirculation and homing.
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    Annual Review of Immunology 16 (1998), S. 359-393 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation may be initiated by an array of co-stimulatory receptors, specificity is provided by inhibitory signals transduced by receptors for MHC class I. Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules. A common pathway of inhibitory signaling is provided by ITIM sequences in the cytoplasmic domains of these otherwise structurally diverse receptors. Upon ligand binding and activation, the inhibitory NK cell receptors become tyrosine phosphorylated and recruit tyrosine phosphatases, SHP-1 and possibly SHP-2, resulting in inhibition of NK cell-mediated cytotoxicity and cytokine expression. Recent studies suggest these inhibitory NK cell receptors are members of a larger superfamily containing ITIM sequences, the inhibitory receptor superfamily (IRS).
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    Annual Review of Immunology 16 (1998), S. 433-470 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: Abstract This review summarizes the clinical history and rationale for xenotransplantation; recent progress in understanding the physiologic, immunologic, and infectious obstacles to the procedure's success; and some of the strategies being pursued to overcome these obstacles. The problems of xenotransplantation are complex, and a combination of approaches is required. The earliest and most striking immunologic obstacle, that of hyperacute rejection, appears to be the closest to being solved. This phenomenon depends on the binding of natural antibody to the vascular endothelium, fixation of complement by that antibody, and finally, activation of the endothelium and initiation of coagulation. Therefore, these three pathways have been targeted as sites for intervention in the process. The mechanisms responsible for the next immunologic barrier, that of delayed xenograft/acute vascular rejection, remain to be fully elucidated. They probably also involve multiple pathways, including antibody and/or immune cell binding and endothelial cell activation. The final immunologic barrier, that of the cellular immune response, involves mechanisms that are similar to those involved in allograft rejection. However, the strength of the cellular immune response to xenografts is so great that it is unlikely to be controlled by the types of nonspecific immunosuppression used routinely to prevent allograft rejection. For this reason, it may be essential to induce specific immunologic unresponsiveness to at least some of the most antigenic xenogeneic molecules.
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    Annual Review of Immunology 16 (1998), S. 545-568 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: Abstract Covalent attachment of activated complement C3 (C3d) to antigen links innate and adaptive immunity by targeting antigen to follicular dendritic cells (FDC) and B cells via specific receptors CD21 and CD35. Recent characterization of knockout mice deficient in complement components C3, C4, or the receptors CD21 and CD35 as well as biochemical studies of the CD21/CD19/Tapa-1 coreceptor on B cells have helped to elucidate the mechanism of complement regulation of both B-1 and B-2 lymphocytes. Interestingly, natural antibody of the adaptive immune system provides a major recognition role in activation of the complement system, which in turn enhances activation of antigen-specific B cells. Enhancement of the primary and secondary immune response to T-dependent antigens is mediated by coligation of the coreceptor and the B cell antigen receptor, which dramatically increases follicular retention and B cell survival within the germinal center. Most recent evidence suggests that complement also regulates elimination of self-reactive B cells, as breeding of mice that are deficient in C4 or CD21/CD35 with the lupus-prone strain of lpr mice demonstrates an exacerbation of disease due to an increase in autoantibodies.
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    Annual Review of Immunology 17 (1999), S. 1-17 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Work done in the late 1950s and in the 1960s revealed the role of the thymus in virus-induced leukemia in mice. Thymectomizing mice at birth to test whether the virus first multiplied in thymus tissue and then spread elsewhere ultimately led to the conclusion that the thymus was essential to the normal development of the immune system. Subsequent testing to try to understand how the thymus contributes to the pool of immunocompetent lymphocytes opened a new chapter in immunology and required a reappraisal of many immunological phenomena and an understanding of the molecular interactions that take place during cell-to-cell interactions.
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    Annual Review of Immunology 17 (1999), S. 19-49 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Interleukin-15 (IL-15) is a 14- to 15-kDa member of the 4 alpha-helix bundle family of cytokines. IL-15 expression is controlled at the levels of transcription, translation, and intracellular trafficking. In particular, IL-15 protein is posttranscriptionally regulated by multiple controlling elements that impede translation, including 12 upstream AUGs of the 5' UTR, 2 unusual signal peptides, and the C-terminus of the mature protein. IL-15 uses two distinct receptor and signaling pathways. In T and NK cells the IL-15 receptor includes IL-2/15Rbeta and gammac, subunits, which are shared with IL-2, and an IL-15-specific receptor subunit, IL-15Ralpha. Mast cells respond to IL-15 with a receptor system that does not share elements with the IL-2 receptor but uses a novel 60- to 65-kDa IL-15RX subunit. In mast cells IL-15 signaling involves Jak2/STAT5 activation rather than the Jak1/Jak3 and STAT5/STAT3 system used in activated T cells. In addition to its other functional activities in immune and nonimmune cells, IL-15 plays a pivotal role in the development, survival, and function of NK cells. Abnormalities of IL-15 expression have been described in patients with rheumatoid arthritis or inflammatory bowel disease and in diseases associated with the retroviruses HIV and HTLV-I. New approaches directed toward IL-15, its receptor, or its signaling pathway may be of value in the therapy of these disorders.
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    Annual Review of Immunology 17 (1999), S. 189-220 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to mediate significant levels of cytotoxic activity and produce high levels of certain cytokines and chemokines. NK cells respond to and are important in defense against a number of different infectious agents. The first indications for this function came from the observations that virus-induced interferons alpha/beta (IFN-alpha and -beta) are potent inducers of NK cell-mediated cytotoxicity, and that NK cells are important contributors to innate defense against viral infections. In addition to IFN-alpha/beta, a wide range of other innate cytokines can mediate biological functions regulating the NK cell responses of cytotoxicity, proliferation, and gamma interferon (IFN-gamma) production. Certain, but not all, viral infections induce interleukin 12 (IL-12) to elicit NK cell IFN-gamma production and antiviral mechanisms. However, high levels of IFN-alpha/beta appear to be unique and/or uniquely dominant in the context of viral infections and act to regulate other innate responses, including induction of NK cell proliferation in vivo and overall negative regulation of IL-12 production. A detailed picture is developing of particular innate cytokines activating NK cell responses and their consorted effects in providing unique endogenous milieus promoting downstream adaptive responses, most beneficial in defense against viral infections.
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    Annual Review of Immunology 17 (1999), S. 331-367 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-alpha, LT-alpha, LT-beta, and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF receptor (CD120a), the p75 TNF receptor (CD120b), the lymphotoxin beta receptor (LTbetaR), and herpes virus entry mediator (HVEM) to control a wide range of innate and adaptive immune response functions. Of these, the most thoroughly studied are cell death induction and regulation of the inflammatory process. Fas/Apo1 (CD95), a receptor of the TNF receptor family activated by a distinct ligand, induces death in cells through mechanisms shared with CD120a. The last four years have seen a proliferation in knowledge of the proteins participating in the signaling by the TNF system and CD95. The downstream signaling molecules identified so far-caspases, phospholipases, the three known mitogen activated protein (MAP) kinase pathways, and the NF-kappaB activation cascade-mediate the effects of other inducers as well. However, the molecules that initiate these signaling events, including the death domain- and TNF receptor associated factor (TRAF) domain-containing adapter proteins and the signaling enzymes associated with them, are largely unique to the TNF/nerve growth factor receptor family.
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    Annual Review of Immunology 17 (1999), S. 369-397 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural basis of cellular immune recognition. Crystal structures have been determined for full-length and truncated forms of alphabeta T cell receptor (TCR) heterodimers, both alone and in complex with their peptide-MHC (pMHC) ligands or with anti-TCR antibodies. In addition, a truncated CD8 coreceptor has been visualized with a pMHC. Aided in large part by the substantial body of knowledge accumulated over the last 25 years on antibody structure, a number of general conclusions about TCR structure and its recognition of antigen can already be derived from the relatively few TCR structures that have been determined. Small, but important, variations between TCR and antibody structures bear on their functional differences as well as on their specific antigen recognition requirements. As observed in antibodies, canonical CDR loop structures are already emerging for some of the TCR CDR loops. Highly similar docking orientations of the TCR Valpha domains in the TCR/pMHC complex appear to play a primary role in dictating orientation, but the Vbeta positions diverge widely. Similar TCR contact positions, but whose exact amino acid content can vary, coupled with relatively poor interface shape complementarity, may explain the flexibility and short half-lives of many TCR interactions with pMHC. Here we summarize the current state of this field, and suggest that the knowledge gap between the three-dimensional structure and the signaling function of the TCR can be bridged through a synthesis of molecular biological and biophysical techniques.
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    Annual Review of Immunology 17 (1999), S. 555-592 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development. Combinations of intracellular signaling pathways downstream of these PTKs determine the quality and quantity of BCR signaling. For example, concerted actions of the PLC-gamma2 and PI3-K pathways are required for proper calcium responses. Similarly, the regulation of ERK and JNK responses involves both PLC-gamma2 and GTPases pathways. Since the immune response in vivo is regulated by alteration of these signaling outcomes, achieving a precise understanding of intracellular molecular events leading to B lymphocyte proliferation, deletion, anergy, receptor editing, and survival still remains a challenge for the future.
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    Annual Review of Immunology 17 (1999), S. 593-623 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Phagocytosis of pathogens by macrophages initiates the innate immune response, which in turn orchestrates the adaptive response. In order to discriminate between infectious agents and self, macrophages have evolved a restricted number of phagocytic receptors, like the mannose receptor, that recognize conserved motifs on pathogens. Pathogens are also phagocytosed by complement receptors after relatively nonspecific opsonization with complement and by Fc receptors after specific opsonization with antibodies. All these receptors induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle. However, important differences in the molecular mechanisms underlying phagocytosis by different receptors are now being appreciated. These include differences in the cytoskeletal elements that mediate ingestion, differences in vacuole maturation, and differences in inflammatory responses. Infectious agents, such as M. tuberculosis, Legionella pneumophila, and Salmonella typhimurium, enter macrophages via heterogeneous pathways and modify vacuolar maturation in a manner that favors their survival. Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response.
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    Annual Review of Immunology 17 (1999), S. 781-828 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract The immune system relies on cell death to maintain lymphoid homeostasis and avoid disease. Recent evidence has indicated that the caspase family of cysteine proteases is a central effector in apoptotic cell death and is absolutely responsible for many of the morphological features of apoptosis. Cell death, however, can occur through caspase-independent and caspase-dependent pathways. In the case of cells that are irreversibly neglected or damaged, death occurs even in the absence of caspase activity. In contrast, healthy cells require caspase activation to undergo cell death induced by surface receptors. This review summarizes the current understanding of these two pathways of cell death in the immune system.
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    Annual Review of Immunology 17 (1999), S. 973-976 
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    Annual Review of Immunology 1 (1983), S. 87-115 
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    Annual Review of Immunology 1 (1983), S. 143-173 
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    Annual Review of Immunology 1 (1983), S. 335-359 
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    Annual Review of Immunology 1 (1983), S. 307-327 
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    Annual Review of Immunology 1 (1983), S. 439-461 
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    Annual Review of Immunology 1 (1983), S. 529-568 
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    Annual Review of Immunology 23 (2005), S. 161-196 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Our views regarding the origins and functions of splenic marginal zone B cells have changed considerably over the past few years. Perspectives regarding the development and function of these cells vary considerably between investigators studying human and rodent immunology. Marginal zone B cells are now recognized to constitute a distinct naive B lymphoid lineage. Considerable progress has been made regarding the mechanisms involved in marginal zone B cell development in the mouse. Many of the molecular events that participate in the retention of this lineage of B cells in the marginal zone have been identified. Here, we discuss the functions of these cells in both innate and adaptive immunity. We also attempt to reconcile differing viewpoints regarding the generation and function of marginal zone B cells in rodents and primates.
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    Annual Review of Immunology 23 (2005), S. 487-513 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Helper T (Th) cellĐ??regulated B cell immunity progresses in an ordered cascade of cellular development that culminates in the production of antigen-specific memory B cells. The recognition of peptide MHC class II complexes on activated antigen-presenting cells is critical for effective Th cell selection, clonal expansion, and effector Th cell function development (Phase I). Cognate effector Th cellĐ??B cell interactions then promote the development of either short-lived plasma cells (PCs) or germinal centers (GCs) (Phase II). These GCs expand, diversify, and select high-affinity variants of antigen-specific B cells for entry into the long-lived memory B cell compartment (Phase III). Upon antigen rechallenge, memory B cells rapidly expand and differentiate into PCs under the cognate control of memory Th cells (Phase IV). We review the cellular and molecular regulators of this dynamic process with emphasis on the multiple memory B cell fates that develop in vivo.
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    Annual Review of Immunology 23 (2005), S. 415-445 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: The proliferation and differentiation of lymphocytes are regulated by receptors localized on the cell surface. Engagement of these receptors induces the activation of intracellular signaling proteins that transmit the receptor signals to distinct targets and control the cellular responses. The first signaling proteins to be discovered in higher organisms were the products of oncogenes. For example, the kinases Src and Abelson (Abl) were originally identified as oncogenes and were later characterized as important proteins for signal transduction in various cell types, including lymphocytes. Now, as many cellular signaling molecules have been discovered and ordered into certain pathways, we can better understand why particular signaling proteins are associated with tumorigenesis. In this review, we discuss recent progress in unraveling the molecular mechanisms of signaling pathways that control the proliferation and differentiation of early B cells. We point out the concepts of auto-inhibition and subcellular localization as crucial aspects in the regulation of B cell signaling.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 23 (2005), S. 683-747 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Multiple sclerosis (MS) develops in young adults with a complex predisposing genetic trait and probably requires an inciting environmental insult such as a viral infection to trigger the disease. The activation of CD4+ autoreactive T cells and their differentiation into a Th1 phenotype are a crucial events in the initial steps, and these cells are probably also important players in the long-term evolution of the disease. Damage of the target tissue, the central nervous system, is, however, most likely mediated by other components of the immune system, such as antibodies, complement, CD8+ T cells, and factors produced by innate immune cells. Perturbations in immunomodulatory networks that include Th2 cells, regulatory CD4+ T cells, NK cells, and others may in part be responsible for the relapsing-remitting or chronic progressive nature of the disease. However, an important paradigmatic shift in the study of MS has occurred in the past decade. It is now clear that MS is not just a disease of the immune system, but that factors contributed by the central nervous system are equally important and must be considered in the future.
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    Annual Review of Immunology 23 (2005), S. 651-682 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: CD8+ T cells play a critical role in antiviral immunity by exerting direct antiviral activity against infected cells. Because of their ability to recognize all types of viral proteins, they offer the promise of providing broad immunity to viruses that evade humoral immunity by varying their surface proteins. Consequently, there is considerable interest in developing vaccines that elicit effective antiviral TCD8+ responses. Generating optimal vaccines ultimately requires rational design based on detailed knowledge of how TCD8+ are activated in vivo under natural circumstances. Here we review recent progress obtained largely by in vivo studies in mice to understand the mechanistic basis for activation of naive TCD8+ in virus infections. These studies point the way to detailed understanding and provide some key information for vaccine development, although much remains to be learned to enable truly rational vaccine design.
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    Annual Review of Immunology 23 (2005), S. 945-974 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: The Notch pathway is gaining increasing recognition as a key regulator of developmental choices, differentiation, and function throughout the hematolymphoid system. Notch controls the generation of hematopoietic stem cells during embryonic development and may affect their subsequent homeostasis. Commitment to the T??cell lineage and subsequent stages of early thymopoiesis is critically regulated by Notch. Recent data indicate that Notch can also direct the differentiation and activity of peripheral T and B cells. Thus, the full spectrum of Notch effects is just beginning to be understood. In this review, we discuss this explosion of knowledge as well as current controversies and challenges in the field.
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    Annual Review of Immunology 1 (1983), S. 119-142 
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    Annual Review of Immunology 1 (1983), S. 211-241 
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    Annual Review of Immunology 1 (1983), S. 393-422 
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    Annual Review of Immunology 23 (2005), S. 975-1028 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: The conversion of exogenous and endogenous proteins into immunogenic peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic events culminating in the formation of peptides bound to MHC class I or class II molecules. Although the biochemistry of these events has been studied in detail, only in the past few years has similar information begun to emerge describing the cellular context in which these events take place. This review thus concentrates on the properties of antigen-presenting cells, especially those aspects of their overall organization, regulation, and intracellular transport that both facilitate and modulate the processing of protein antigens. Emphasis is placed on dendritic cells and the specializations that help account for their marked efficiency at antigen processing and presentation both in vitro and, importantly, in vivo. How dendritic cells handle antigens is likely to be as important a determinant of immunogenicity and tolerance as is the nature of the antigens themselves.
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    Annual Review of Immunology 23 (2005), S. 515-548 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
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    Notes: The discovery of new functions for the original B7 family members, together with the identification of additional B7 and CD28 family members, have revealed new ways in which the B7:CD28 family regulates T cell activation and tolerance. B7-1/B7-2:CD28 interactions not only promote initial T cell activation but also regulate self-tolerance by supporting CD4+CD25+ T regulatory cell homeostasis. CTLA-4 can exert its inhibitory effects in both B7-1/B7-2 dependent and independent fashions. B7-1 and B7-2 can signal bidirectionally by engaging CD28 and CTLA-4 on T cells and by delivering signals into B7-expressing cells. The five new B7 family members, ICOS ligand, PD-L1 (B7-H1), PD-L2 (B7-DC), B7-H3, and B7-H4 (B7x/B7-S1) are expressed on professional antigen-presenting cells as well as on cells within nonlymphoid organs, providing new means for regulating T cell activation and tolerance in peripheral tissues. The new CD28 families members, ICOS, PD-1, and BTLA, are inducibly expressed on T cells, and they have important roles in regulating previously activated T cells. PD-1 and BTLA also are expressed on B cells and may have broader immunoregulatory functions. The ICOS:ICOSL pathway appears to be particularly important for stimulating effector T cell responses and T cellĐ??dependent B cell responses, but it also has an important role in regulating T cell tolerance. In addition, the PD-1:PD-L1/PD-L2 pathway plays a critical role in regulating T cell activation and tolerance. In this review, we revisit the roles of the B7:CD28 family members in regulating immune responses, and we discuss their therapeutic potential.
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    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 26 (2005), S. 877-900 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an invariant T cell antigen receptor (TCR) ʼ̛ chain, and unusual requirements for thymic selection. They rapidly produce many cytokines after stimulation and thus influence diverse immune responses and pathogenic processes. Because of intensive research effort, we have learned much about factors promoting the development and survival of NKT cells, regulation of their cytokine production, and the means by which they influence dendritic cells and other cell types. Despite this progress, knowledge of the natural antigen(s) they recognize and their physiologic role remain incomplete. The activation of NKT cells paradoxically can lead either to suppression or stimulation of immune responses, and we cannot predict which will occur. Despite this uncertainty, many investigators are hopeful that immune therapies can be developed based on NKT cell stimulation.
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    Annual Review of Immunology 23 (2005), S. 549-600 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: The Tec family tyrosine kinases are now recognized as important mediators of antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec, are expressed in T cells and activated in response to T cell receptor (TCR) engagement. Although initial studies demonstrated a role for these proteins in TCR-mediated activation of phospholipase C-??, recent data indicate that Tec family kinases also regulate actin cytoskeletal reorganization and cellular adhesion following TCR stimulation. In addition, Tec family kinases are activated downstream of G proteinĐ??coupled chemokine receptors, where they play parallel roles in the regulation of Rho GTPases, cell polarization, adhesion, and migration. In all these systems, however, Tec family kinases are not essential signaling components, but instead function to modulate or amplify signaling pathways. Although they quantitatively reduce proximal signaling, mutations that eliminate Tec family kinases in T cells nonetheless qualitatively alter T cell development and differentiation.
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    Notes: The immune response to the malaria parasite is complex and poorly understood. Although antibodies and T cells can control parasite growth in model systems, natural immunity to malaria in regions of high endemicity takes several years to develop. Variation and polymorphism of antibody target antigens are known to impede immune responses, but these factors alone cannot account for the slow acquisition of immunity. In human and animal model systems, cell-mediated responses can control parasite growth effectively, but such responses are regulated by parasite load via direct effects on dendritic cells and possibly on T and B cells as well. Furthermore, high parasite load is associated with pathology, and cell-mediated responses may also harm the host. Inflammatory cytokines have been implicated in the pathogenesis of cerebral malaria, anemia, weight loss, and respiratory distress in malaria. Immunity without pathology requires rapid parasite clearance, effective regulation of the inflammatory antiparasite effects of cellular responses, and the eventual development of a repertoire of antibodies effective against multiple strains. Data suggest that this may be hastened by exposure to malaria antigens in low dose, leading to augmented cellular immunity and rapid parasite clearance.
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    Annual Review of Immunology 23 (2005), S. 23-68 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Several members of the tumor necrosis factor receptor (TNFR) family function after initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB (CD137), OX40 (CD134), HVEM, CD30, and GITR, all of which can have costimulatory effects on T cells. The effects of these costimulatory TNFR family members can often be functionally, temporally, or spatially segregated from those of CD28 and from each other. The sequential and transient regulation of T cell activation/survival signals by different costimulators may function to allow longevity of the response while maintaining tight control of T cell survival. Depending on the disease condition, stimulation via costimulatory TNF family members can exacerbate or ameliorate disease. Despite these complexities, stimulation or blockade of TNFR family costimulators shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity.
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    Annual Review of Immunology 23 (2005), S. 447-485 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Autoimmunity is a complex process that likely results from the summation of multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of autoimmune disease and an important tool for dissecting tolerance mechanisms. The strength of this mouse strain is that it develops spontaneous autoimmune diabetes, which shares many similarities to autoimmune or type 1a diabetes (T1D) in human subjects, including the presence of pancreas-specific autoantibodies, autoreactive CD4+ and CD8+ T cells, and genetic linkage to disease syntenic to that found in humans. During the past ten years, investigators have used a wide variety of tools to study these mice, including immunological reagents and transgenic and knockout strains; these tools have tremendously enhanced the study of the fundamental disease mechanisms. In addition, investigators have recently developed a number of therapeutic interventions in this animal model that have now been translated into human therapies. In this review, we summarize many of the important features of disease development and progression in the NOD strain, emphasizing the role of central and peripheral tolerance mechanisms that affect diabetes in these mice. The information gained from this highly relevant model of human disease will lead to potential therapies that may alter the development of the disease and its progression in patients with T1D.
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    Annual Review of Immunology 23 (2005), S. 101-125 
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    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Recent studies have demonstrated that cell membranes provide a unique environment for protein-protein and protein-lipid interactions that are critical for the assembly and function of the T cell receptor (TCR)-CD3 complex. Highly specific polar interactions among transmembrane (TM) domains that are uniquely favorable in the lipid environment organize the association of the three signaling dimers with the TCR. Each of these three assembly steps depends on the formation of a three-helix interface between one basic and two acidic residues in the membrane environment. The same polar TM residues that drive assembly also play a central role in quality control and export by directing the retention and degradation of free subunits and partial complexes, while membrane proximal cytoplasmic signals control recycling and degradation of surface receptors. Recent studies also suggest that interactions between the membrane and the cytoplasmic domains of CD3 proteins may be important for receptor triggering.
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    Annual Review of Immunology 2 (1984), S. 199-218 
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    Annual Review of Immunology 2 (1984), S. 283-318 
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    Annual Review of Immunology 2 (1984), S. 359-394 
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    Annual Review of Immunology 2 (1984), S. 395-428 
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    Annual Review of Immunology 2 (1984), S. 429-459 
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    Annual Review of Environment and Resources 5 (1980), S. 61-88 
    ISSN: 0362-1626
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    Topics: Energy, Environment Protection, Nuclear Power Engineering
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    Annual Review of Environment and Resources 5 (1980), S. 141-172 
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    Annual Review of Environment and Resources 5 (1980), S. 173-240 
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    Annual Review of Environment and Resources 5 (1980), S. 293-333 
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    Annual Review of Environment and Resources 5 (1980), S. 357-387 
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