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  • Pregnancy  (45)
  • Mutation
  • American Association for the Advancement of Science (AAAS)  (66)
  • Elsevier
  • American Institute of Physics (AIP)
  • 1975-1979  (66)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (66)
  • Elsevier
  • American Institute of Physics (AIP)
  • Springer  (11)
Years
Year
  • 1
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    Difference between postpartum and nutritional amenorrhea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frisch, R E -- McArthur, J W -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419411" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*etiology/physiopathology ; Body Weight ; Female ; Humans ; Lactation ; Nutrition Disorders/complications ; Pregnancy ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human placental membranes, human lymphoblastoid cells, and mouse liver membranes; and measures the receptor independently of its binding function. Down-regulation, or loss of binding after exposure to insulin, is associated with loss of immunoreactive receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harrison, L C -- Flier, J -- Itin, A -- Kahn, C R -- Roth, J -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):544-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/83675" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Binding Sites ; Binding Sites, Antibody ; Epitopes ; Female ; Humans ; Liver/analysis ; Lymphocytes/analysis ; Mice ; Placenta/analysis ; Pregnancy ; Radioimmunoassay/methods ; Receptor, Insulin/analysis/*immunology ; Solubility
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide adenosine and deoxyadenosine adducts: structure and stereochemistry (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉
    Keywords: *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Scientists attack report that obstetrical medications endanger children (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Apr 27;204(4391):391-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/87012" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthesia, Obstetrical/*adverse effects ; Child ; Child Development/*drug effects ; Child, Preschool ; Delivery, Obstetric/methods ; Developmental Disabilities/chemically induced ; Female ; Humans ; Infant ; Infant, Newborn ; Labor, Obstetric ; Methods ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: In rats, a single injection of clomiphene citrate (Clomid) during pregnancy causes multiple abnormalities of the reproductive tract in the offspring and mothers. These abnormalities probably result from the ability of Clomid to cause long-term estrogenic stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCormack, S -- Clark, J H -- New York, N.Y. -- Science. 1979 May 11;204(4393):629-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432668" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*pathology ; Animals ; Clomiphene/*toxicity ; Fallopian Tubes/pathology ; Female ; Metaplasia ; Pregnancy ; Pregnancy, Animal/*drug effects ; Rats ; Uterine Diseases/chemically induced/pathology ; Vaginal Diseases/chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Dynamics of skeletal pattern formation in developing chick limb (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that could be the basis of the emergent primordia. As cellular differentiation proceeds, the size of the mesenchymal diffusion chamber is reduced in descrete steps, leading to sequential reorganizations of the morphogen pattern. The successive patterns correspond to observed rows of skeletal elements, whose emergence, in theory and in practice, depends on the maintenance of a unique boundary condition at the limb bud apex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newman, S A -- Frisch, H L -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):662-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462174" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone and Bones/*embryology ; Cell Differentiation ; Chick Embryo ; Diffusion ; Extremities/*embryology ; Growth Substances/physiology ; Mesoderm/cytology ; Models, Biological ; Muscles/embryology ; Mutation ; Wings, Animal/*embryology
    Print ISSN: 0036-8075
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  • 8
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    Osmotic shock prevents nuclear exchange and produces whole-genome homozygotes in conjugating Tetrahymena (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-16
    Description: Exposure of conjugating Tetrahymena to a hyperosmotic shock blocks the exchange of gametic nuclei and produces self-fertilized exconjugants that are homozygous for their whole genome. Cells are sensitive to this induction during a brief period after meiosis. The high efficiency of the treatment and the fertility of the progeny make this a useful method for the isolation of induced recessive mutations and enhances the value of Tetrahymena as an animal-cell model system in which genetic dissection is practical. The sharp peak of sensitivity is useful in the study of those cellular mechanisms responsible for the independent handling of several functionally distinct nuclei during conjugation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orias, E -- Hamilton, E P -- Flacks, M -- New York, N.Y. -- Science. 1979 Feb 16;203(4381):660-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760210" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/physiology ; Conjugation, Genetic ; Genes, Recessive ; Homozygote ; Mutation ; Osmotic Pressure ; Tetrahymena/*genetics
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  • 9
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    Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-29
    Description: The concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH)2D during lactation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pike, J W -- Parker, J B -- Haussler, M R -- Boass, A -- Toverud, S V -- New York, N.Y. -- Science. 1979 Jun 29;204(4400):1427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451573" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/blood ; Dihydroxycholecalciferols/*blood ; Female ; Hydroxycholecalciferols/*blood ; *Lactation ; Parathyroid Glands/physiology ; Parathyroid Hormone/physiology ; Phosphorus/blood ; Pregnancy ; *Pregnancy, Animal ; Rats
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Nickel carbonyl: prenatal exposure (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warner, J S -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1194-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424746" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Female ; Humans ; Ketones/*toxicity ; Nickel/*toxicity ; Occupational Medicine ; Pregnancy ; Rats ; *Teratogens
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Effects of anesthesia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Feb 23;203(4382):705.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419403" target="_blank"〉PubMed〈/a〉
    Keywords: *Abnormalities, Drug-Induced ; Abortion, Spontaneous/*chemically induced ; Anesthetics/*adverse effects ; Female ; Humans ; Male ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Evidence for extra-renal 1 alpha-hydroxylation of 25-hydroxyvitamin D3 in pregnancy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The kidneys are thought to be the only organs capable of 1 alpha-hydroxylation of vitamin D and its metabolites. We have examined the in vivo conversion of 3H-(25,26)-25-hydroxyvitamin D3(25OHD3) to 3H-(25,26)-1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in vitamin D-deficient, pregnant and nonpregnant rats. As expected, nephrectomy of nonpregnant, vitamin D-deficient rats prevented the conversion of 25OHD3 to 1 alpha,25(OH)2D3. In contrast, nephrectomy of pregnant, vitamin D-deficient rats reduced but did not abolish the formation of 1 alpha,25(OH)2D3 from its precursor. The identity of the radioactive metabolite formed from 3H-25OHD3 which circulated in nephrectomized, pregnant rats was established as 1 alpha,25(OH)2D3 by comigration with synthetic 1 alpha,25(OH)2D3 on high-pressure liquid chromatography. The simultaneous absence of 1 alpha,25(OH)2D3 in the fetal kidneys indicated that the site of 1 alpha-hydroxylation after nephrectomy of the pregnant rat was probably extra-renal in origin. Two sites of 1 alpha-hydroxylation of 25OHD3, one renal and the other extra-renal, either fetoplacental or maternal, may exist in the pregnant, vitamin D-deficient rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gray, T K -- Lester, G E -- Lorenc, R S -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dihydroxycholecalciferols/biosynthesis ; Female ; Fetal Blood/metabolism ; Hydroxycholecalciferols/*metabolism ; Hydroxylation ; Kidney/embryology/metabolism ; *Nephrectomy ; Placenta/metabolism ; Pregnancy ; *Pregnancy, Animal
    Print ISSN: 0036-8075
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  • 13
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    Toxaphene, a complex mixture of polychloroterpenes and a major insecticide, is mutagenic (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: Toxaphene, the most widely used chlorinated insecticide, is mutagenic in the Salmonella test without requiring liver homogenate for activity. This insecticide is a complex mixture (more than 177 polychloroterpenes) with carcinogenic activity in rodents. Some but not all of the mutagenic components are easily separated from the insecticidal ingredients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hooper, N K -- Ames, B N -- Saleh, M A -- Casida, J E -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):591-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377495" target="_blank"〉PubMed〈/a〉
    Keywords: Dose-Response Relationship, Drug ; Insecticides/*pharmacology ; *Mutagens ; Mutation ; Salmonella typhimurium/drug effects ; Toxaphene/*pharmacology
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  • 14
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    Normal anterior endoderm corrects the heart defect in cardiac mutant salamanders (Ambystoma mexicanum) (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Recessive mutant gene c in axolotl embryos results in an absence of heart function. Normal (+/+) anterior endoderm cultured with mutant (c/c) hearts totally corrects the defect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemanski, L F -- Paulson, D J -- Hill, C S -- New York, N.Y. -- Science. 1979 May 25;204(4395):860-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/441740" target="_blank"〉PubMed〈/a〉
    Keywords: Ambystoma/*embryology/genetics ; Animals ; Culture Techniques ; Embryonic Induction ; Endoderm/physiology ; Genes, Recessive ; Heart/*embryology ; Mutation ; Myocardium/ultrastructure
    Print ISSN: 0036-8075
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  • 15
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    Albumin-deficient rat mutant (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagase, S -- Shimamune, K -- Shumiya, S -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):590-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Aberrations/*blood ; Chromosome Disorders ; Crosses, Genetic ; Female ; Immunoelectrophoresis ; Male ; Mutation ; Rats/*genetics ; Serum Albumin/*deficiency ; Serum Globulins/analysis
    Print ISSN: 0036-8075
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  • 16
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    Membrane potential changes during chemokinesis in Paramecium (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Intracellular recordings show that (i) paramecia hyperpolarize slightly in attractants and depolarize in repellents that depend on the avoiding reaction (an abrupt change of swimming direction), and (ii) paramecia more strongly hyperpolarize in repellents and more strongly depolarize in attractants that depend on changes of swimming velocity. These membrane potential changes are in agreement with a hypothesis of membrane potential control of chemokinesis in Paramecium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Houten, J -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1100-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572085" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; *Chemotaxis ; Escape Reaction/physiology ; *Membrane Potentials ; Mutation ; Paramecium/*physiology
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  • 17
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    Phenacetin studies (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaught, J B -- King, C M -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):637, 639.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493967" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Kidney Injury/chemically induced ; Animals ; Biotransformation ; *Carcinogens ; Humans ; Kidney Neoplasms/chemically induced ; Mice ; Mutation ; Phenacetin/*adverse effects/metabolism
    Print ISSN: 0036-8075
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  • 18
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    Fetal research ethics (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brackbill, Y -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):404-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504983" target="_blank"〉PubMed〈/a〉
    Keywords: Abortion, Induced ; Disclosure ; *Ethics, Medical ; Female ; Fetus/*physiology ; Humans ; Informed Consent ; Pregnancy ; *Risk Assessment
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  • 19
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    Ethanol embryotoxicity: direct effects on mammalian embryos in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethanol, which causes reduced embryonic cellular proliferation early in gestation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, N A -- Goulding, E H -- Fabro, S -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Ectogenesis/*drug effects ; Embryo, Mammalian/*drug effects ; Ethanol/*toxicity ; Female ; Fetal Growth Retardation/chemically induced ; Pregnancy ; Rats ; *Teratogens
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  • 20
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    Release of luteinizing hormone in male mice during exposure to females: habituation of the response (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coquelin, A -- Bronson, F H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1099-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Diestrus ; Female ; Habituation, Psychophysiologic/*physiology ; Luteinizing Hormone/*metabolism ; Male ; Mice ; Pregnancy ; Sexual Behavior, Animal/physiology
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  • 21
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    Prenatal stress reduces fertility and fecundity in female offspring (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Female rats subjected to prenatal stress later experienced fewer conceptions, more spontaneous abortions and vaginal hemorrhaging, longer pregnancies, and fewer viable young than nonstressed rats. The offspring of the prenatally stressed rats were lighter in weight and less likely to survive the neonatal period. Prenatal stress may influence the balance of adrenal and gonadal hormones during a critical stage of fetal hypothalamic differentiation, thereby producing a variety of reproductive dysfunctions in adulthood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herrenkohl, L R -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1097-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573923" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/etiology ; Female ; Gestational Age ; Humans ; Infertility, Female/*etiology ; Lighting ; Litter Size ; Maternal Behavior ; Pregnancy ; Rats ; Reproduction ; Stress, Psychological/*complications
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  • 22
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    Fetal mortality and sex ratio (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lowry, J T -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1428.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505019" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Fetal Death/*epidemiology ; Humans ; Male ; Pregnancy ; *Sex Ratio
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  • 23
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    Hydrostatic pressure reversibly blocks membrane control of ciliary motility in Paramecium (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: A hydrostatic pressure of only 68 atmospheres prevented swimming Paramecium caudatum from "avoiding" or reversing direction; 170 atmospheres stopped or decreased forward velocity by more than 75 percent. A decompression of 40 atmospheres invoked a single reversal, even at ,80 atmospheres. In contrast, 170 atmospheres did not significantly affect swimming behavior of paramecium "models" that were reactivated in a solution containing adenosine triphosphate and magnesium ions after their membrane had been disrupted by Triton X-100.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Otter, T -- Salmon, E D -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482945" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/physiology ; Cilia/physiology ; Hydrostatic Pressure ; Ion Channels/physiology ; Membrane Potentials ; Movement ; Mutation ; Paramecium/genetics/*physiology ; Polyethylene Glycols/pharmacology
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  • 24
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    Acetaminophen: potentially toxic metabolite formed by human fetal and adult liver microsomes and isolated fetal liver cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: A reactive metabolite of acetaminophen is hepatotoxic in humans when the drug is ingested in large overdoses. The ability of the human fetal and adult liver to oxidize acetaminophen by trapping the potentially toxic metabolite as a glutathione conjugate has been measured. Oxidation by fetal liver was approximately ten times slower than by adult liver. However, there was a definite increase in acetaminophen oxidation with fetal age. Isolated human fetal liver cells conjugated acetaminophen with sulfate but not with glucuronic acid. The results indicate that the human fetal liver is able to detoxify acetaminophen by conjugation. However, it also catalyzes the formation of an active metabolite of acetaminophen through oxidation. Hence the fetus remains at risk should a large dose of the drug cross into the fetal circulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rollins, D E -- von Bahr, C -- Glaumann, H -- Moldeus, P -- Rane, A -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1414-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/38505" target="_blank"〉PubMed〈/a〉
    Keywords: Acetaminophen/*metabolism/toxicity ; Biotransformation ; Cytochrome P-450 Enzyme System/metabolism ; Female ; Glutathione/metabolism ; Humans ; Liver/embryology ; Maternal-Fetal Exchange ; Microsomes, Liver/*metabolism ; NADP/metabolism ; Pregnancy
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  • 25
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    Genetic variance in nonverbal intelligence: data from the kinships of identical twins (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: The multiple relationships within kinships of adult monozygotic twins permit incisive analyses to be made of genetic and environmental effects on behavioral traits. Data from families of 65 monozygotic twin pairs yield evidence of genetic variance on the Block Design Test, a nonverbal measure of general intelligence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rose, R J -- Harris, E L -- Christian, J C -- Nance, W E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1153-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572991" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Humans ; *Intelligence ; Pedigree ; Pregnancy ; *Twins ; *Twins, Monozygotic ; Wechsler Scales
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  • 26
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    Enduring changes in dopamine receptor cells of pups from drug administration to pregnant and nursing rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: A decrease in specific [3H]spiroperidol binding to rat caudate tissue and a parallel decrease in sensitivity to apomorphine in eliciting stereotyped behavior was observed in the offspring of rat mothers treated with either haloperidol or alpha-methyl-p-tyrosine-methyl ester during pregnancy. In contrast, evidence of increased dopamine-receptor sensitivity was observed in the pups if haloperidol was administered to their mothers postpartum during nursing rather than during pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosengarten, H -- Friedhoff, A J -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1133-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/570724" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Corpus Striatum/*drug effects/embryology/growth & development ; Female ; Fetus/*drug effects ; Haloperidol/*pharmacology ; Humans ; *Lactation ; Maternal-Fetal Exchange ; Methyltyrosines/*pharmacology ; Pregnancy ; Rats ; Receptors, Dopamine/*drug effects ; Stereotyped Behavior/drug effects
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  • 27
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    Siamese cat: altered connections of visual cortex (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: In siamese cats, each side of the brain receives a retinal input serving part of the ipsilateral visual field as well as the normal contralateral field representation. Both corticothalamic and cortico-cortical projections are systematically rearranged, but while one is retinotopically appropriate, the other fails to make a distinction between ipsilateral and contralateral fields. Different rules appear to govern the development of these two sets of connections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shatz, C J -- LeVay, S -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):328-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; Cats/*anatomy & histology/growth & development ; Functional Laterality ; Geniculate Bodies/anatomy & histology ; Mutation ; Retina/*anatomy & histology ; Visual Cortex/*anatomy & histology ; Visual Pathways/anatomy & histology/growth & development
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  • 28
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    EPA halts most use of herbicide 2,4,5-T (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, J -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1090-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424734" target="_blank"〉PubMed〈/a〉
    Keywords: 2,4,5-Trichlorophenoxyacetic Acid/adverse effects/*standards ; Abortion, Spontaneous/*chemically induced ; Female ; Government Agencies ; Humans ; Legislation, Drug ; Pregnancy ; Tetrachlorodibenzodioxin/toxicity ; United States
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  • 29
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    Prednisone therapy and birth weight (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, K D -- Steinberger, E -- Rodriguez-Rigau, L J -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):96-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482933" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Weight/*drug effects ; Female ; Humans ; Prednisone/*adverse effects ; Pregnancy
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  • 30
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    Oxytocin receptors: triggers for parturition and lactation? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Specific binding of tritiated oxytocin to uterine receptors of pregnant rats increases dramatically at term and is maximal during labor. In mammary glands the increase in binding is gradual, reaching a maximum during the lactation period. Concomitant changes in the sensitivity of the uterus and mammary gland to oxytocin indicate that the receptor concentration is of functional significance. Oxytocin receptors, therefore, may regulate the response of the target organs to circulating oxytocin and thereby control the onset of labor and lactation. Ovarian steroids participate in the regulation of oxytocin receptors in a manner as yet unclarified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Soloff, M S -- Alexandrova, M -- Fernstrom, M J -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1313-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/221972" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/blood ; Female ; Kinetics ; *Labor, Obstetric ; *Lactation ; Mammary Glands, Animal/metabolism ; Myometrium/*metabolism ; Oxytocin/blood/*metabolism ; Pregnancy ; Progesterone/blood ; Receptors, Cell Surface/*metabolism ; Uterus/*metabolism
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  • 31
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    Eye malformations in rats: induction by prenatal exposure to nickel carbonyl (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-02-09
    Description: Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sunderman, F W Jr -- Allpass, P R -- Mitchell, J M -- Baselt, R C -- Albert, D M -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):550-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/104388" target="_blank"〉PubMed〈/a〉
    Keywords: Abnormalities, Drug-Induced/*embryology/pathology ; Animals ; Anophthalmos/chemically induced ; Carcinogens ; *Eye Abnormalities ; Female ; Gestational Age ; Ketones/*toxicity ; Microphthalmos/chemically induced ; Nickel/*toxicity ; Pregnancy ; Rats ; Teratogens
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  • 32
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    Iodide-induced hypothyroidism: a potential hazard during perinatal life (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-03
    Description: The administration of iodide to pregnant and nursing rats induces hypothyroidism in the term fetus and neonatal rat through age 10 days as indicated by an increase in the serum concentration of thyroid-stimulating hormone and a decrease in the serum of thyroxine and triiodothyronine. Thyroid function returned to normal from age 18 through 60 days in spite of continued iodide administration, strongly suggesting that resistance to the inhibitory effect of iodide on thyroid hormone synthesis is developed at approximately 18 days of age. This perinatal rat model can be used to study the mechanisms responsible for iodide-induced hypothyroidism and goiter in human newborns whose mothers received iodide-containing medications during pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Theodoropoulos, T -- Braverman, L E -- Vagenakis, A G -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):502-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451615" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Female ; Fetus ; Hypothyroidism/chemically induced/*physiopathology ; *Iodides ; Lactation ; Pregnancy ; Rats ; Thyrotropin/blood ; Thyroxine/blood ; Triiodothyronine/blood
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  • 33
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    Psychotropic drugs as behavioral teratogens (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-21
    Description: Three psychotropic drugs were administered to pregnant rats and were then evaluated for their behavioral and reproductive effects in the offspring. Control rats received either saline or vitamin A. Prochlorperazine had the most disruptive effects on reproduction and growth, but had the least effect on behavior. Propoxyphene had no apparent effects on reproduction or growth, but produced a variety of behavioral changes. Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development. The data suggest that systematic tests of behavior add important information to evaluations of reproductive toxicity that cannot, at present, be obtained by other means.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vorhees, C V -- Brunner, R L -- Butcher, R E -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1220-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472738" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Brain Chemistry/drug effects ; Dextropropoxyphene/*pharmacology ; *Disease Models, Animal ; Female ; Fenfluramine/*pharmacology ; Humans ; Litter Size/drug effects ; Male ; Movement Disorders/chemically induced ; Pregnancy ; Pregnancy, Animal/*drug effects ; Prochlorperazine/*pharmacology ; Rats ; Reproduction/drug effects ; Sex Ratio/drug effects ; Swimming
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  • 34
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    Delay of constant light-induced persistent vaginal estrus by 24-hour time cues in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: The normal ovarian cycle of female rats is typically replaced by persistent estrus when these animals are housed under constant light. Evidence presented here shows that the maintenance of periodicity in the environment can at least delay (if not prevent) the photic induction of persistent vaginal estrus. Female rats in constant light were exposed to vaginal smearing at random times or at the same time every day. In another experiment, female rats were exposed to either constant bright light, constant dim light, or a 24-hour photic cycle of bright and dim light. The onset of persistent vaginal estrus was delayed in rats exposed to 24-hour time cues even though the light intensities were the same as or greater than those for the aperiodic control groups. The results suggest that the absence of 24-hour time cues in constant light contributes to the induction of persistent estrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weber, A L -- Adler, N T -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571146" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks ; Dose-Response Relationship, Radiation ; Estrus/*radiation effects ; Female ; *Light ; Periodicity/radiation effects ; Pregnancy ; Rats ; Time Factors
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  • 35
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    Sex pheromone in the dog (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-02-09
    Description: Methyl p-hydroxybenzoate has been identified in the vaginal secretions of female dogs in estrus. When small amounts of this compound were applied to the vulvas of anestrous or spayed females, males placed with these females became sexually aroused and attempted to mount them.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goodwin, M -- Gooding, K M -- Regnier, F -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569903" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dogs/*physiology ; *Estrus ; Female ; Hydroxybenzoates ; Male ; Pheromones/*physiology ; Posture ; Pregnancy ; Proestrus ; Sex Attractants/*physiology ; Sexual Behavior, Animal/physiology ; Smell ; Vagina/physiology
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  • 36
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    Prednisone therapy and birth weight (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jefferies, W M -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):96-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482932" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Cortex Hormones/*adverse effects ; Birth Weight/drug effects ; Cortisone/adverse effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Hydrocortisone/adverse effects ; Prednisone/*adverse effects ; Pregnancy
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  • 37
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    Differential mortality by sex in fetal and neonatal deaths (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Vital statistics data for the United States from 1922 to 1936 and from 1950 to 1972 were used to analyze fetal and early neonatal mortality. This analysis corroborates the previously established pattern of the sex ratio of fetal deaths--highest from months 3 to 5, lower from months 6 to 7 or 8, and increasing at term. It also indicates a postponement of late fetal deaths into the early infant period. Whereas earlier research reports have described the pattern of the sex ratio of fetal deaths, this report repeats this analysis for a recent national data base. This line of analysis is extended by using the patterns observed in the data to produce an empirical estimate of the primary sex ratio. For 1950 to 1972, this ratio (male to female) is conservatively estimated to be 120:100.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMillen, M M -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571144" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Fetal Death/*epidemiology ; Humans ; *Infant Mortality ; Male ; Pregnancy ; *Sex Ratio ; United States
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Water, protein folding, and the genetic code (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: The absolute affinities of amino acid side chains for solvent water closely match their relative distributions between the surface and the interior of native proteins and are associated with a remarkable bias in the genetic code.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfenden, R V -- Cullis, P M -- Southgate, C C -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):575-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493962" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/*genetics ; *Genetic Code ; Mutation ; Protein Conformation ; Solubility ; Thermodynamics ; Water
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-24
    Description: Sulfhydryl reagents exert a profound influence on the monodeiodination of thyroxine to triiodothyronine by rat and sheep tissues in vitro. A marked dithiothreitol-induced increase in the monodeiodination by fetal sheep liver homogenates suggests that the characteristically low conversion in fetal tissues is related more to the status of sulfhydryl groups than to a deficiency of the monodeiodinating enzyme.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chopra, I J -- New York, N.Y. -- Science. 1978 Feb 24;199(4331):904-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622575" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dithiothreitol/pharmacology ; Female ; Fetus/*metabolism ; Liver/embryology/*metabolism ; Pregnancy ; Rats ; Sheep ; Sulfhydryl Compounds/*metabolism ; Sulfhydryl Reagents/pharmacology ; Thyroxine/*metabolism ; Triiodothyronine/*metabolism
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Dieldrin-induced mortality in an endangered species, the gray bat (Myotis grisescens) (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Brains of juvenile gray bats, Myotis grisescens, found dead beneath maternity roosts in two Missouri caves contained lethal concentrations of dieldrin. One colony appeared to be abnormally small, and more dead bats were found a year after the juvenile bats had been collected. This is the first report to link the field mortality of bats directly to insecticide residues acquired through the food chain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, D R Jr -- LaVal, R K -- Swineford, D M -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1357-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/564550" target="_blank"〉PubMed〈/a〉
    Keywords: Aldrin/adverse effects ; Animals ; Body Weight ; Brain Chemistry ; *Chiroptera ; Dieldrin/*adverse effects/analysis ; Environmental Exposure ; Female ; Lactation ; Male ; Missouri ; Pesticide Residues ; Pregnancy
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    Hepatitis B virus and sex ratio of offspring (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Drew, J S -- London, W T -- Lustbader, E D -- Hesser, J E -- Blumberg, B S -- New York, N.Y. -- Science. 1978 Aug 25;201(4357):687-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/566954" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Birth Order ; Cross Reactions ; Female ; Fetal Death ; Graft Survival ; Hepatitis B/immunology/*physiopathology/transmission ; Hepatitis B Surface Antigens/analysis ; Humans ; Male ; Parity ; Pregnancy ; Sex Factors ; *Sex Ratio
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    Malignant neoplasms of genetic origin in Drosophila melanogaster (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-30
    Description: Malignant neoplasms that develop in 12 recessive-lethal, larval mutants of Drosophila melanogaster are discussed. These mutations affect the adult optic neuroblasts and ganglion-mother cells in the larval brain, the imaginal discs, and the hematopoietic organs. The malignant neoplasms exhibit fast, autonomous growth, loss of the capacity for differentiation, increased mobility and invasiveness, lethality in situ and after transplantation, and histological, fine structural, and karyotypic abnormalities. Intermediate neoplasms are also found. These combine both benign and malignant qualities. They grow in a noninvasive, compact fashion, typical of benign tumors, yet they also exhibit malignant qualities such as fast, autonomous, and lethal growth, loss of differentiation capacity, changes in cellular morphology, and lethal growth after transplantation into wild-type hosts. Thus Drosophila and vertebrate neoplasms show striking similarities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gateff, E -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1448-59.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96525" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Cells/pathology ; *Cell Transformation, Neoplastic ; Drosophila melanogaster/*genetics/growth & development ; Ecdysone/pharmacology ; Hematopoiesis ; Mutation ; Neoplasm Transplantation ; Neoplasms, Experimental/*genetics/pathology ; Neuroblastoma/genetics/pathology
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    Estrogen formation in the early rabbit embryo (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: Androgen formation (3beta-hydroxysteroid dehydrogenase activity) was detectable in the rabbit blastocyst on day 5 of gestation (before implantation); estrogen formation was first detectable on day 7. The capacity to form estrogen on the day of implantation suggests that estrogen formation in the blastocyst may play a role in the implantation process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉George, F W -- Wilson, J D -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):200-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/579477" target="_blank"〉PubMed〈/a〉
    Keywords: 3-Hydroxysteroid Dehydrogenases/*metabolism ; Androgens/biosynthesis ; Animals ; Blastocyst/*metabolism ; *Embryo Implantation ; Embryonic Development ; Estradiol/*biosynthesis ; Female ; Gestational Age ; Pregnancy ; Rabbits
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    alpha1-Antitrypsin: the presence of excess mannose in the Z variant isolated from liver (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: The Z variant of alpha1-antitrypsin was isolated by a new technique from the liver of a patient homozygous for the Z allele of the protease inhibitor locus. The material was homogenous and antigenically competent but had no protease inhibiting capacity. An interesting correlation was found between the subcellular localization and the carbohydrate composition of the Z variant from liver. Carbohydate analysis of this glycoprotein showed an absence of galactose and sialic acid, an appreciable decrease in N-acetylglucosamine, and an almost twofold increase in mannose residues. These data indicate a considerable slowdown in the processing of the oligosaccharides of liver Z variant. In spite of the absence of sialyl residues, the liver Z varant was microheterogeneous by analytical isoelectric focusing. The isoproteins of liver Z variant coincided with those of asialo M variant in the focusing field.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hercz, A -- Katona, E -- Cutz, E -- Wilson, J R -- Barton, M -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1229-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/308696" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Carbohydrate Metabolism ; Female ; Galactose/metabolism ; Glycoproteins/genetics ; Homozygote ; Humans ; Liver/metabolism ; Mannose/metabolism ; Middle Aged ; Mutation ; Phenotype ; Sialic Acids/metabolism ; alpha 1-Antitrypsin/*genetics/metabolism
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    S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-11-17
    Description: When adenosine deaminase activity is inhibited, low concentrations of adenosine are toxic to human lymphoblast mutants that are unable to convert adenosine to intracellular nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was identified in extracts of human lymphoblasts and placenta as the enzyme S-adenosylhomocysteine hydrolase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hershfield, M S -- Krodich, N M -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):757-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715439" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine/*metabolism ; Adenosine Deaminase/*deficiency ; Carrier Proteins/*metabolism ; Female ; Humans ; Hydrolases/*metabolism ; Kinetics ; Lymphocytes/metabolism ; Nucleoside Deaminases/*deficiency ; Placenta/metabolism ; Pregnancy ; S-Adenosylhomocysteine/metabolism
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    Enhanced dexamethasone resistance in cystic fibrosis cells: potential use for heterozygote detection and prenatal diagnosis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Cultured skin fibroblasts from patients with cystic fibrosis (CF) are more resistant to dexamethasone toxicity than are normal cells. We now report that, when fibroblasts cultured from obligate CF heterozygotes are exposed to dexamethasone, they have an intermediate survival compared to normal and homozygous CF cells. When dexamethasone survival was tested on cells from four patients undergoing amniocentesis, cells from a woman at risk of producing a child with CF showed significant dexamethasone resistance, similar to that of fibroblasts derived from lnown CF homozygotes; the other amniotic cell specimens showed dexamethasone sensitivity similar to that of normal skin fibroblasts. These data suggest that the dexamethasone resistance previously observed in skin fibroblasts may also be useful in the prenatal diagnosis of CF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, J L -- Epstein, J -- Fontaine, J H -- Forbes, G B -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):180-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663650" target="_blank"〉PubMed〈/a〉
    Keywords: Amniotic Fluid/cytology ; Cell Survival/drug effects ; Cystic Fibrosis/diagnosis/genetics/*physiopathology ; Dexamethasone/*toxicity ; Drug Resistance ; Female ; Heterozygote ; Homozygote ; Humans ; Pregnancy ; Prenatal Diagnosis
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    Postpartum amenorrhea: how is it affected by maternal nutritional status? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: The average length of postpartum amenorrhea reported by breast-feeding women in rural Bangladesh in 1975 was 18 to 20 months. Its duration was found to be only slightly related to maternal nutritional status. There was no evidence of a threshold of weight for height necessary for the resumption of menses postpartum. Factors related to the duration of postpartum amenorrhea were maternal age, socioeconomic status, and supplemental feeding of the infant.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huffman, S L -- Chowdhury, A K -- Mosley, W H -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1155-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653359" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*etiology ; Body Water/metabolism ; Body Weight ; Female ; Humans ; Infant Nutritional Physiological Phenomena ; *Lactation ; Maternal Age ; Menstruation ; Nutrition Disorders/metabolism ; *Nutritional Physiological Phenomena ; *Postpartum Period ; Pregnancy ; Socioeconomic Factors ; Time Factors
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    Prenatal diagnosis of genetic disorders (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-05-26
    Description: Sampling of amniotic fluid, visualization of the fetus, fetal blood sampling, and screening of maternal blood represent successive approaches to the diagnosis of specific genetic disorders in the second trimester of pregnancy. Clinical and ethical concerns about the appropriateness, safety, and efficacy of the techniques have led to multidisciplinary assessments at an early stage. A major growth in demand for medical and educational genetic services can be anticipated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Omenn, G S -- New York, N.Y. -- Science. 1978 May 26;200(4344):952-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/77042" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Amniocentesis/adverse effects/methods ; Amniotic Fluid/analysis ; Chromosome Aberrations/diagnosis ; Chromosome Disorders ; Congenital Abnormalities/diagnosis ; Female ; Fetal Blood/analysis ; Fetoscopy/methods ; Genetic Diseases, Inborn/*diagnosis/therapy ; Humans ; Metabolism, Inborn Errors/diagnosis ; Pregnancy ; Prenatal Diagnosis/*methods ; Ultrasonography ; alpha-Fetoproteins/analysis
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    Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-01-13
    Description: The inability of nursing pups to survive on milk of mice homozygous for the recessive mutation, lethal milk (lm), is correlated with a reduction in zinc levels of both milk and pup carcass. Administration of zinc to pups nursing on lmlm dams reduces the observed mortality and morbidity. It is suggested that lm alters zinc transport from maternal blood to milk and that its study may provide useful information for understanding the rare human disease, acrodermatitis enteropathica.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Piletz, J E -- Ganschow, R E -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; *Lactation ; Mice ; Mice, Inbred C57BL/*genetics ; Milk/*metabolism ; Pregnancy ; Zinc/blood/*deficiency/metabolism
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    Restriction enzymes: prenatal diagnosis of genetic disease (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1068-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715458" target="_blank"〉PubMed〈/a〉
    Keywords: Anemia, Sickle Cell/*diagnosis/genetics ; DNA Restriction Enzymes/*metabolism ; Female ; Globins/genetics ; Humans ; Pregnancy ; Prenatal Diagnosis/*methods ; Thalassemia/*diagnosis
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    The problem of defensive medicine (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-05-26
    Description: Defensive medicine--the use of diagnostic and end-treatment measures explicitly for the purposes of averting malpractice suits--is frequently cited as one of the least desirable effects of the current rise in medical litigation. Many physicians and policy-makers claim that defensive medicine is responsible not only for the increasing costs of health care but the exposing of patients to significant risks of harm from unnecessary procedures. Very little solid information is available about defensive medicine. The studies that have been conducted have been fraught with statistical difficulties and are by no means definitive. Even more important than the issue of defensive medicine is the more basic problem of our system of compensation for medical injuries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tancredi, L R -- Barondess, J A -- New York, N.Y. -- Science. 1978 May 26;200(4344):879-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644329" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Cesarean Section/utilization ; Child ; Costs and Cost Analysis ; Craniocerebral Trauma/radiography ; *Defensive Medicine/economics ; Female ; Fetal Monitoring/utilization ; Humans ; *Malpractice/economics ; Physician-Patient Relations ; Pregnancy ; Quality of Health Care ; Surveys and Questionnaires ; United States
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    Stimulated DNA synthesis in frog nuclei by cytoplasmic extracts of temperature-sensitive mammalian cells (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-08-18
    Description: Cytoplasmic extracts of proliferating cells stimulate DNA synthesis in isolated nuclei of Xenopus laevis liver. When tested by the same assay, cytoplasmic extracts of resting cells are completely inactive. When cytoplasmic extracts are prepared from cell cycle-specific temperature-sensitive mutants arrestd in the G1 phase of the cell cycle by the nonpermissive temperature, they also fail to stimulate DNA synthesis in frog nuclei. The results indicate that, to stimulate DNA synthesis in isolated frog nuclei, essentially all information of G1 cells must be present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floros, J -- Chang, H -- Baserga, R -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):651-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675253" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cell Nucleus/*metabolism ; Chickens ; Cytoplasm/physiology ; DNA/*biosynthesis ; Liver/ultrastructure ; Mutation ; Temperature ; Xenopus
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    Prolactin synthesis by human chorion-decidual tissue: a possible source of prolactin in the amniotic fluid (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Explants of human chorion-decidual tissue obtained at delivery from normal, full-term pregnancies synthesize and secrete prolactin. This hormone is indistinguishable from pituitary prolactin by chromatographic, electrophoretic, immunologic, and receptor assay techniques. These results suggest that chorion-decidua may be the source of the large quantities of prolactin in amniotic fluid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Golander, A -- Hurley, T -- Barrett, J -- Hizi, A -- Handwerger, S -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):311-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694535" target="_blank"〉PubMed〈/a〉
    Keywords: Amnion/metabolism ; Amniotic Fluid/*metabolism ; Chorion/*metabolism ; Decidua/*metabolism ; Female ; Humans ; In Vitro Techniques ; Pregnancy ; Prolactin/*biosynthesis ; Trophoblasts/metabolism
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    Primate infant's effects on mother's future reproduction (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-09-15
    Description: Female savanna baboons (Papio cynocephalus) had a longer postpartum amenorrhea and thereafter cycled longer before conceiving if their previous infant survived than if that infant died. Among mothers of surviving infants, differences in maternal care produced differences in age of weaning and age of independence but did not result in differences in interbirth intervals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altmann, J -- Altmann, S A -- Hausfater, G -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1028-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/98844" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea ; Animals ; Female ; Haplorhini ; Maternal Behavior ; Papio/*physiology ; *Postpartum Period ; Pregnancy ; *Reproduction ; Time Factors ; Weaning
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    Behavioral teratology: birth defects of the mind (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):732-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/568821" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthesia, Obstetrical/adverse effects ; Behavior/*drug effects ; Female ; Gonadal Steroid Hormones/adverse effects ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases/chemically induced ; Male ; Mental Disorders/*chemically induced ; Narcotics ; Pregnancy ; Semen/metabolism ; Spermatozoa/drug effects ; Substance Withdrawal Syndrome/etiology ; *Teratogens/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Attraction by repellents: an error in sensory information processing by bacterial mutants (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Normal Escherichia coli bacteria are repelled by acetate, benzoate, and indole and attracted by alpha-aminoisobutyrate. We have isolated mutants that are attracted to acetate, benzoate, and indole and may be repelled by alpha-aminoisobutyrate. These reversed-taxis mutants are defective in a central processing component: a set of methylated proteins known as MCP 1. The mechanism of reversal of taxis is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muskavitch, M A -- Kort, E N -- Springer, M S -- Goy, M F -- Adler, J -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):63-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351803" target="_blank"〉PubMed〈/a〉
    Keywords: Acetates ; Bacterial Proteins/genetics/physiology ; Benzoates ; *Chemotaxis ; Escherichia coli/genetics/*physiology ; Indoles ; Methylation ; Mutation ; Receptors, Drug/physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Chloroquine resistance produced in vitro in an African strain of human malaria (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: After condinous cultivation in the presence of chloroquine, an African strain of the malaria parasite, Plasmodium falciparu, acquired resistance to the drug. The resistance was stable and comparable in vitro to that occurring naturally in a strain from Southeast Asia. This suggests that chloroquine resistance, absent until now in Africa, might arise in the future.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nguyen-Dinh, P -- Trager, W -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1397-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351801" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chloroquine/*pharmacology ; Drug Resistance ; Mutation ; Plasmodium falciparum/*drug effects/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Supplemental lighting stimulates growth and lactation in cattle (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-24
    Description: Sixteen hours of light daily (114 to 207 lux) increased weight gains and milk yield 10 to 15% in Holstein cattle in comparison with cattle exposed to natural-length photoperiods (39 to 93 lux) of 9 to 12 hours. The weight gain was accomplished without increased consumption of feed. Manipulation of supplemental light may thus cause dramatic increases in food supplies from animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peters, R R -- Chapin, L T -- Leining, K B -- Tucker, H A -- New York, N.Y. -- Science. 1978 Feb 24;199(4331):911-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622576" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cattle/*growth & development ; Female ; *Lactation ; *Lighting ; Pregnancy ; Temperature ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 59
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    6-Mercaptopurine treatment of pregnant mice: effects on second and third generations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reimers, T J -- Sluss, P M -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663638" target="_blank"〉PubMed〈/a〉
    Keywords: 6-Mercaptopurine/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Fetal Death/*chemically induced ; Fetus/drug effects ; Germ Cells/*drug effects ; Infertility, Female/*chemically induced ; Litter Size/drug effects ; Mice ; Ovary/cytology/drug effects/embryology ; Pregnancy ; Pregnancy, Animal/*drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 60
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    Control of sequential compartment formation in Drosophila (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-20
    Description: During development of Drosophila melanogaster, sequential commitment to alternative development programs occurs in neighboring groups of cells. These commitments appear to be reflected by lines of clonal restriction, called compartmental boundaries, which progressively subdivide the early embryo, and later the imaginal discs, which give rise to different adult appendages. We propose that a reaction-diffusion system acts throughout development and generates a sequence of differently shaped chemical patterns. These patterns account for the sequence and geometries of compartmental boundaries, and predict that each terminal compartment is specifiied by a unique combination of binary choices made during its formation. This binary "code" interprets coherently the patterned metaplasia seen in transdetermination and homeotic mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kauffman, S A -- Shymko, R M -- Trabert, K -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):259-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/413193" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blastoderm/cytology ; Cell Differentiation ; Clone Cells/cytology ; Drosophila melanogaster/cytology/embryology/*growth & development ; Embryo, Nonmammalian/cytology ; Models, Biological ; Mutation ; Wings, Animal/growth & development
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    An ultrastructural correlate of the membrane mutant "paranoiac" in Paramecium (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: The highly organized array of intramembranous particles, the ciliary plaque, varies from the wild type in size and organization in two stocks of the Paramecium behavioral mutant, paranoiac. In one of these stocks, the alteration is dramatic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Byrne, B J -- Byrne, B C -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1091-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628834" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/ultrastructure ; Cilia/ultrastructure ; Locomotion ; Mutation ; Paramecium/*genetics/physiology/ultrastructure ; Sodium/pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Nutrition, population, and health: some implications for policy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Winikoff, B -- New York, N.Y. -- Science. 1978 May 26;200(4344):895-902.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644332" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/physiology ; Birth Rate ; Breast Feeding ; Female ; Food Supply ; *Health ; Humans ; Infant ; Infant Mortality ; Infant Nutritional Physiological Phenomena ; Milk, Human ; Nutrition Disorders/mortality/physiopathology ; *Nutritional Physiological Phenomena ; *Population Dynamics ; Pregnancy ; Public Policy
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Synchronies in mental development: an epigenetic perspective (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Early mental development is analyzed from an evolutionary viewpoint and related to the dynamic interplay of genetic programming, maturational status, and environmental influence. Data are reported from a large sample of twins and siblings who have been tested longitudinally from 3 months to 6 years of age. Monozygotic twins became increasingly concordant with age and also paralleled each other for the spurts and lags in development. Dizygotic twins became less concordant with age and eventually matched their singleton siblings as closely as one another. The overall results suggested that the course of mental development is guided by the intrinsic scheduling of the genetic program acting in concert with maturational status and environmental influence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, R S -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):939-48.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/568822" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/physiology ; *Biological Evolution ; Child ; Child, Preschool ; Environment ; Female ; Genes ; *Growth ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Intelligence ; Mental Processes/*physiology ; Pregnancy ; *Twins
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 64
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    A mutant of yeast defective in cellular morphogenesis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: In the budding yeast Saccharomyces cerevisiae, each bud appears within a ring of chitin formed in the cell wall of the mother cell. Temperature-sensitive mutants defective in gene cdc24 synthesize chitin at restrictive temperatures, but do not organize it into the discrete rings found in normal cells, nor do they form buds. The chitin ring or an annular precursor structure may play an essential role in reinforcing the region of the cell wall involved in budding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sloat, B F -- Pringle, J R -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1171-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/349694" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Wall/metabolism/ultrastructure ; Chitin/biosynthesis/metabolism ; Microscopy, Fluorescence ; *Morphogenesis ; Mutation ; Saccharomyces cerevisiae/genetics/*ultrastructure
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Genetic method for the preferential elimination of females of anopheles albimanus (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-16
    Description: Recent field experiments demonstrated the possibility of using the sterile male method for the control of Anopheles albimanus Wiedemann, the most important vector of human malaria in Central America. Until now there was no practical method for excluding females from the releases of sterile males. A genetic method was developed for the preferential elimination of females during any of the four life stages. This genetic sexing system utilizes propoxur (o-isopropoxyphenyl methyl-carbamate) susceptibility as a recessive conditional lethal a T(Y:2R) translocation, and an In(2R)inversion. The propoxur resistance allele (dominant) was linked to the Y chromosome via a radiation-induced translocation, and genetic recombination was suppressed by inversions. In one of the strains produced, 99.7 percent of the females are eliminated when treated with propoxur, without male loss.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seawright, J A -- Kaiser, P E -- Dame, D A -- Lofgren, C S -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1303-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663614" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Anopheles/drug effects/genetics ; Female ; Genetic Linkage ; Infertility, Male ; Insect Control/*methods ; Male ; Mutation ; Pest Control, Biological/methods ; Propoxur/pharmacology ; Sex Chromosomes
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Corticosterone concentrations in the mouse (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spackman, D H -- Riley, V -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):87.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635580" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Circadian Rhythm ; Corticosterone/*blood ; Female ; Mice/*blood ; Pregnancy ; Radioimmunoassay
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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