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  • Cell Line  (35)
  • American Association for the Advancement of Science (AAAS)  (35)
  • Springer Science + Business Media
  • American Chemical Society (ACS)
  • 1975-1979  (35)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (35)
  • Springer Science + Business Media
  • American Chemical Society (ACS)
Years
Year
  • 1
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    Thiourea reverses cross-links and restores biological activity in DNA treated with dichlorodiaminoplatinum (II) (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Cis and trans dichlorodiaminoplatinum (II) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt (II) treatment of lambda decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated lambda DNA can be restored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Filipski, J -- Kohn, K W -- Prather, R -- Bonner, W M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571145" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Coliphages ; DNA/*metabolism ; DNA, Neoplasm/metabolism ; DNA, Viral/metabolism ; Leukemia L1210 ; Organoplatinum Compounds/*antagonists & inhibitors ; Structure-Activity Relationship ; Thiourea/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
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  • 3
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    Permeability of the cell-to-cell membrane channels in mammalian cell juncton (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flagg-Newton, J -- Simpson, I -- Loewenstein, W R -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):404-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Membrane/physiology ; *Cell Membrane Permeability ; Cells, Cultured ; Cricetinae ; Fluorescent Antibody Technique ; Kidney ; Mice ; Mice, Inbred BALB C ; Species Specificity
    Print ISSN: 0036-8075
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  • 4
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    Membrane effects of thyrotropin-releasing hormone and estrogen shown by intracellular recording from pituitary cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: The effects of thyrotropin-releasing hormone and 17 beta-estradiol on the electrical membrane properties of a prolactin-secretin pituitary cell line (GH3/B6) were studied with intracellular microelectrode recordings. Of the cells tested, 50 percent were excitable and displayed calcium-dependent action potentials when depolarized. When injected directly on the membrane of an excitable cell, thyrotropin-releasing hormone and 17 beta-estradiol induced action potentials within 1 minute. The spiking activity was preceded by a progressive increase of the input resistance without any detectable change in the resting membrane polarization. The results reveal a rapid effect of both substances on the membrane of GH3/B6 cells. In the case of thyrotropin-releasing hormone, which has both a short-term effect on release of prolactin and a long-term effect on its synthesis, the induced electrical activity may be associated with the stimulation of prolactin production. The physiological implication of 17 beta-estradiol-induced, calcium-dependent spiking activity remains to be elucidated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dufy, B -- Vincent, J D -- Fleury, H -- Du Pasquier, P -- Gourdji, D -- Tixier-Vidal, A -- New York, N.Y. -- Science. 1979 May 4;204(4392):509-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107590" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Cell Line ; Cell Membrane/drug effects ; Estradiol/*pharmacology ; Pituitary Gland/*drug effects ; Stimulation, Chemical ; Thyrotropin-Releasing Hormone/*pharmacology
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  • 5
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    Opiate (Enkephalin) receptors of neuroblastoma cells: occurrence in clusters on the cell surface (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: A bioactive, fluorescent derivative of enkephalin, Tyr-D-Ala-Gly-Phe-Leu-Lys-rhodamine, was used to determine the distribution of opiate receptors in living neuroblastoma cells. The receptors appeared in clusters on the cell surface, and no internalization was detected. No specific fluorescence or clusters were observed in the presence of [D-Ala2, Leu5]enkephalin or at 4 degrees C, and the clusters were much reduced under ionic conditions (that is, with 100 millimolars sodium) that specifically decrease the binding of opiate agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Mice ; Microscopy, Fluorescence ; Neoplasms, Experimental/metabolism ; Neuroblastoma/*metabolism ; Receptors, Opioid/*metabolism ; Synaptic Membranes/metabolism
    Print ISSN: 0036-8075
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  • 6
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    Noncycling tumor cells are sensitive targets for the antiproliferative activity of human interferon (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Resting Burkitt's lymphoma cells (Daudi) in culture are more sensitive targets for the antiproliferative activity of purified human fibroblast interferon than cells that are rapidly multiplying. Thus, interferon may be of significant clinical value in neoplasms involving stem cells and, after chemotherapy, in suppressing the reemergence of tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horoszewicz, J S -- Leong, S S -- Carter, W A -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1091-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493995" target="_blank"〉PubMed〈/a〉
    Keywords: Burkitt Lymphoma/drug therapy/pathology ; Cell Cycle/drug effects ; Cell Division/*drug effects ; Cell Line ; Cells, Cultured ; Humans ; Interferons/*pharmacology/therapeutic use ; Lymphocytes/drug effects
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  • 7
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    Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marcu, K B -- Schibler, U -- Perry, R P -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1087-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109919" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cell Line ; Cell Nucleus/metabolism ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/immunology ; Nucleic Acid Precursors/genetics ; Plasmacytoma/immunology ; Poly A/metabolism ; RNA, Heterogeneous Nuclear/genetics ; *Transcription, Genetic
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  • 8
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    Chemotactic responses of tumor cells to products of resorbing bone (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factoor is released by a variety of agents that induce resorption of bone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Orr, W -- Varani, J -- Gondex, M K -- Ward, P A -- Mundy, G R -- New York, N.Y. -- Science. 1979 Jan 12;203(4376):176-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569363" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Resorption/*physiopathology ; Bone and Bones/*physiopathology ; Carcinoma 256, Walker/*physiopathology ; Cell Line ; Cell Movement ; *Chemotaxis ; Chemotaxis, Leukocyte ; Lymphoma/physiopathology ; Neoplasm Metastasis ; Neoplasms, Experimental/physiopathology ; Organ Culture Techniques
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  • 9
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    Human macrophage migration inhibition factor: evidence for subunit structure (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: Macrophage migration inhibition factor (MIF) derived from human lymphoid cell lines was found to lose biologic activity on dialysis. Although activity was not recovered in the dialyzate, mixing experiments demonstrated that the components in the retentate and dialyzate could reassociate to restore activity. The fragment of larger molecular weight (less than 10,000) could inhibit the activity of intact MIF, whereas the smaller molecular weight fragment (5,000 to 10,000) could not. These findings suggest that human MIF is composed of at least two noncovalently linked subunits. In analogy to the situation for certain bacterial toxins, one of these may represent an attachment piece for a target cell membrane receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Possanza, G -- Cohen, M C -- Yoshida, T -- Cohen, S -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):300-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377487" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Dialysis ; Humans ; In Vitro Techniques ; Lymphocytes/physiology ; Macromolecular Substances ; *Macrophage Migration-Inhibitory Factors ; Molecular Weight
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  • 10
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    Induction of differentiation in human promyelocytic leukemia cells by tumor promoters (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Phorbol diester tumor promoters and the promoter mezerein convert human promyelocytic leukemia cells in culture into adherent, nonproliferating cells with many of the characteristics of macrophages. Other types of promoters such as anthralin, phenobarbital, and saccharin do not have this effect. Various compounds that can inhibit some of the biological and biochemical effects of tumor promoters do not interfere with the induction of cell adherence and differentiation by the effective promoters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rovera, G -- O'Brien, T G -- Diamond, L -- New York, N.Y. -- Science. 1979 May 25;204(4395):868-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/286421" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Adhesion/drug effects ; Cell Differentiation/*drug effects ; Cell Line ; Humans ; Leukemia, Myeloid, Acute/*pathology ; Phorbol Esters/pharmacology ; Phorbols/*pharmacology ; Tetradecanoylphorbol Acetate/*pharmacology
    Print ISSN: 0036-8075
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  • 11
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    GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: A "recptor unit" for gamma-aminobutyric acid (GABA), which includes brainlike receptor binding sites for tritium-labeled GABA and benzodiazepines (diazepam, clonazepam, and flunitrazepam) and a thermostable endogenous protein (GABA modulin) that inhibits both GABA and benzodiazepine binding, has been demonstrated in membranes prepared from NB2a neuroblastoma and C6 glioma clonal cell lines. In these cells, as in brain, diazepam (1 micromolar) prevents the effect of GABA modulin, and in turn GABA (0.oma and, to a lesser extent, the glioma cells represent a suitable model to study the interactions and the sequence of membrane and intracellular events triggered by the stimulation of benzodiazepine and GABA receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baraldi, M -- Guidotti, A -- Schwartz, J P -- Costa, E -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):821-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepines/*metabolism ; Brain/*metabolism ; Cell Line ; Clonazepam/metabolism ; Clone Cells/metabolism ; Diazepam/metabolism/pharmacology ; Flunitrazepam/metabolism ; Membrane Proteins/pharmacology ; Mice ; Nerve Tissue Proteins/pharmacology ; Rats ; Receptors, Drug/*metabolism ; gamma-Aminobutyric Acid/*metabolism
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  • 12
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    Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-12
    Description: Human and mouse hypoxanthine-guanine phosphoribosyltransferase subunits combine to form an active heteropolymer. Dimers form the basic subunit structure of the enzymes, yet the dimers can readily associate to form tetramers. The equilibrium between dimers and tetramers is significantly influenced by the ionic strength of the enzyme solvent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Johnson, G G -- Eisenberg, L R -- Migeon, B R -- New York, N.Y. -- Science. 1979 Jan 12;203(4376):174-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/569362" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Female ; Genetic Linkage ; Humans ; Hybrid Cells/enzymology ; *Hypoxanthine Phosphoribosyltransferase/genetics ; Macromolecular Substances ; Mice ; Molecular Weight ; Protein Conformation ; X Chromosome
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  • 13
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    Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: C6 glioma cells and B104 neuroblastoma cells both possess adenylate cyclase activity, but only C6 cells have beta-adrenergic receptors. However, when cocultured with B104 cells, C6 cells show a marked decrease in their ability to accumulate adenosine 3', 5'-monophosphate upon stimulation with beta receptor agonists. Since both beta receptors and cholera toxin-stimulated adenylate cyclase activities are present in C6/B104 cocultures, we conclude that the beta receptor/adenylate cyclase transduction mechanism in cocultured C6 cells is uncoupled.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ciment, G -- de Vellis, J -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):765-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/213832" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; *Cell Communication ; Cell Line ; Cholera Toxin/pharmacology ; Cyclic AMP/metabolism ; Enzyme Activation/drug effects ; Membrane Proteins/metabolism ; Protein Binding ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
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  • 14
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    Rabies viruses increase in virulence when propagated in neuroblastoma cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-10
    Description: Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Clark, H F -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1072-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628831" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cells, Cultured ; Mice ; Neuroblastoma/*microbiology ; Neurons/microbiology ; Rabies Vaccines/toxicity ; Rabies virus/genetics/*pathogenicity ; Vaccines, Attenuated/toxicity ; Virus Replication
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  • 15
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    Estrogen-binding sites in endothelial cell cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: The cytosol extracted from a vascular endothelial cell line binds [3H]estradiol with high affinity and a high degree of specificity. In contrast, in experiments performed with cytosol labeled in the intact cell, progesterone and, to a smaller extent, testosterone gave an apparent inhibition of estradiol binding. These data support the concept that ovarian hormones may influence the role of the endothelium in various physiological and pathophysiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Colburn, P -- Buonassisi, V -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):817-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684408" target="_blank"〉PubMed〈/a〉
    Keywords: Aorta/*metabolism ; Cell Line ; Cytosol/metabolism ; Diethylstilbestrol/metabolism ; Endothelium/metabolism ; Estradiol/metabolism ; Progesterone/pharmacology ; Receptors, Estrogen/drug effects/*metabolism ; Testosterone/pharmacology
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  • 16
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    Trisodium phosphonoformate, a new antiviral compound (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Helgstrand, E -- Eriksson, B -- Johansson, N G -- Lannero, B -- Larsson, A -- Misiorny, A -- Noren, J O -- Sjoberg, B -- Stenberg, K -- Stening, G -- Stridh, S -- Oberg, B -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):819-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210500" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antiviral Agents/therapeutic use/toxicity ; Cell Line ; DNA-Directed RNA Polymerases/*antagonists & inhibitors ; Formates/pharmacology/toxicity ; Guinea Pigs ; Herpesviridae Infections/drug therapy ; *Nucleic Acid Synthesis Inhibitors ; Organophosphorus Compounds/*pharmacology/toxicity ; Phosphonoacetic Acid/pharmacology ; Simplexvirus/enzymology
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  • 17
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    Biological activity of some oxygenated sterols (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: A group of oxygenated sterols has been identified as potent and specific inhibitors of sterol biosynthesis. The ability of these compounds to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated sterol rather than by cholesterol. The nature of the regulatory sterol may vary in different cells with their specific requirements for cholesterol as a structural component or as a precursor of other steroid products. The use of oxygenated sterols to block sterol synthesis in cultured cells provides new information regarding the role of sterol in cell membrane structure and function. For example, de novo sterol synthesis is required for DNA synthesis and cell division by some cultured cells. Studies with cultured cells, and with rats and mice in vivo, suggest that oxygenated sterols could be of value in the treatment of several important human diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kandutsch, A A -- Chen, H W -- Heiniger, H J -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):498-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663671" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/metabolism ; Cell Division ; Cell Line ; Cholesterol/biosynthesis/*metabolism ; Feedback ; Humans ; Hydroxycholesterols/*metabolism ; Hydroxymethylglutaryl CoA Reductases/metabolism ; Intestines/metabolism ; Ketosteroids/*metabolism ; Liver/metabolism
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  • 18
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    Enhancement of oncogenesis in C3H/10T1/2 mouse embryo cell cultures by saccharin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: Impure and pure samples of saccharin (2 milligrams per milliliter) did not produce oncogenic transformation of C3H/10T1/2, clone 8, mouse embryo fibroblasts. However, after treatment of the cells with a nontransforming initiating dose (0.1 microgram per milliliter) of 3-methylcholanthrene, continuous treatment with either sample of saccharin (100 micrograms per milliliter) led to significant transformation. It is concluded that in this system saccharin is a cocarginogen, probably functioning as a promoting agent that is 1000-fold less active than the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mondal, S -- Brankow, D W -- Heidelberger, C -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1141-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684434" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Carcinogens ; Cell Line ; Cell Transformation, Neoplastic/*chemically induced ; Cocarcinogenesis ; Embryo, Mammalian ; Methylcholanthrene ; Mice ; Mice, Inbred C3H ; Saccharin/*pharmacology ; Tetradecanoylphorbol Acetate
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  • 19
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    Growth inhibition of transformed cells with succinylated concanavalin A (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G1 phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mannino, R J -- Ballmer, K -- Burger, M M -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):824-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210502" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Adhesion/drug effects ; Cell Cycle/*drug effects ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Concanavalin A/*analogs & derivatives/pharmacology ; Simian virus 40 ; Succinates
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  • 20
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    Generation of new mouse sarcoma viruses in cell culture (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Endogenous nontumor-producing type C viruses from C3H mice were used to generate rapid, solid tumor-inducing variants in cell culture. The new mouse sarcoma viruses induce undifferentiated sarcomas with a short latency period upon inoculation into newborn NIH Swiss mice. Transforming viruses appear only transiently, at a time when the virus-infected cells show morphologic alterations; both before and after this time, transforming viruses cannot be detected. These results show that variants of endogenous type C virus which contain transforming genes (oncogenes) can arise during spread of the endogenous virus in fibroblast lines in vitro as well as in susceptible tissues in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rapp, U R -- Todaro, C -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):821-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/210501" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; *Cell Transformation, Neoplastic ; Cell Transformation, Viral ; *Genes, Viral ; Mice ; Retroviridae/genetics/*pathogenicity ; Sarcoma Viruses, Murine/genetics/pathogenicity ; Sarcoma, Experimental/*microbiology
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  • 21
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    Antibody diversity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-06
    Description: Three important aspects of immunoglobulin gene organization and structure have emerged from studies of cloned immunoglobulin kappa chain genes. (i) Multiple variable genes are encoded separately in the genome of both immunoglobulin-producing and uncommitted (embryonic) cells, thereby establishing the evolutionary base for generating immunoglobulin diversity. (ii) These genes exist as many small, closely related families (subgroups) that share close sequence homology largely within their own subgroup. (iii) Comparison of two cloned variable gene segments derived from a single subgroup reveals a feature of their structure that distinguishes them from fixed genes (that is, globin genes) and provides, through extensive surrounding sequence homology, a large target for intergenic recombination. This last observation suggests that a simple recombination mechanism may account for their genetic instability in both germ line and somatic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seidman, J G -- Leder, A -- Nau, M -- Norman, B -- Leder, P -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):11-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Specificity ; Base Sequence ; Binding Sites, Antibody/*genetics ; Biological Evolution ; Cell Line ; Embryo, Mammalian/immunology ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Light Chains/*genetics ; Immunoglobulin Variable Region/*genetics ; Immunoglobulin kappa-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; Neoplasms, Experimental/immunology ; Plasmacytoma/immunology ; Recombination, Genetic
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  • 22
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    Stimulated DNA synthesis in frog nuclei by cytoplasmic extracts of temperature-sensitive mammalian cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-18
    Description: Cytoplasmic extracts of proliferating cells stimulate DNA synthesis in isolated nuclei of Xenopus laevis liver. When tested by the same assay, cytoplasmic extracts of resting cells are completely inactive. When cytoplasmic extracts are prepared from cell cycle-specific temperature-sensitive mutants arrestd in the G1 phase of the cell cycle by the nonpermissive temperature, they also fail to stimulate DNA synthesis in frog nuclei. The results indicate that, to stimulate DNA synthesis in isolated frog nuclei, essentially all information of G1 cells must be present.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floros, J -- Chang, H -- Baserga, R -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):651-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675253" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cell Nucleus/*metabolism ; Chickens ; Cytoplasm/physiology ; DNA/*biosynthesis ; Liver/ultrastructure ; Mutation ; Temperature ; Xenopus
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  • 23
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    Magnetic microspheres prepared by redox polymerization used in a cell separation based on gangliosides (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: A facile method is described for making magnetic microspheres that bind specifically to cell surfaces, in order to separate cells magnetophoretically. Control over the sizes of the spheres is effected by using their magnetic cores as part of a redox polymerization system. The use of the microspheres is demonstrated with a separation involving C-1300 neuroblastoma cells, 10% of which express the ganglioside GM1 in their membranes. The GM1-containing cells were separated with better than 99% purity, while the deficient cells were obtained at least 98% pure. The separation, which was carried out under sterile conditions, required only 6 minutes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kronick, P L -- Campbell, G L -- Joseph, K -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653356" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Separation/*methods ; *Gangliosides ; Magnetics ; Microspheres ; Neoplasms, Experimental/pathology ; Neuroblastoma/pathology ; Oxidation-Reduction
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  • 24
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    Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells. Receptor agonists for H1, but not H2, caused this effect which was reduced by H1 but not by H2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H1 receptors in these cultured nerve cells stimulated cyclic GMP formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richelson, E -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/pharmacology ; Carbachol/pharmacology ; Cell Line ; Cyclic GMP/*metabolism ; Histamine/*pharmacology ; Histamine H1 Antagonists/pharmacology ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Receptors, Histamine/*drug effects ; Receptors, Histamine H1/*drug effects
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    Myosin: immunofluorescent localization in neuronal and glial cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: The distribution of intracellular myosin was studied by the double antibody immunofluorescence method in primary organotypic neuronal cultures and two established neuronal and glial cell lines. An array of parallel filaments aligned with the major cellular axis and a three-dimensional subsurface network were shown to react with two different myosin antibodies. The presence of myosin-rich filaments in regions known to contain actin filaments suggests that these proteins interact to generate the motive force in nonmuscle contractile systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roisen, F -- Inczedy-Marcsek, M -- Hsu, L -- Yorke, W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1445-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/343252" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cytoplasm/ultrastructure ; Fluorescent Antibody Technique ; Ganglia, Spinal/cytology ; Myosins/*metabolism ; Neuroglia/*metabolism/ultrastructure ; Neurons/*metabolism/ultrastructure
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    Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, H -- Singer, M -- Rosenberg, M -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):394-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Cell Line ; Cercopithecus/*genetics ; Cercopithecus aethiops/*genetics ; DNA/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Haplorhini ; Molecular Weight ; Recombination, Genetic ; Simian virus 40/genetics
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    Human breast cancer: androgen action mediated by estrogen receptor (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-02-17
    Description: Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses significantly increase both DNA and estrogen-dependent protein synthesis. We therefore propose that androgens stimulate MCF-7 cell growth not through the androgen receptor but rather through the estrogen receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zava, D T -- McGuire, W L -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):787-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622569" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*pharmacology ; Breast Neoplasms/*metabolism ; Cell Line ; Cell Nucleus/drug effects/metabolism ; Cytoplasm/drug effects/metabolism ; Dihydrotestosterone/pharmacology ; Humans ; Receptors, Androgen/drug effects ; Receptors, Estrogen/drug effects/*physiology ; Receptors, Glucocorticoid/drug effects/metabolism ; Receptors, Progesterone/drug effects/metabolism ; Stimulation, Chemical ; Translocation, Genetic
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  • 28
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    Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishii, D N -- Fibach, E -- Yamasaki, H -- Weinstein, I B -- New York, N.Y. -- Science. 1978 May 5;200(4341):556-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644318" target="_blank"〉PubMed〈/a〉
    Keywords: Bromodeoxyuridine/antagonists & inhibitors ; Cell Differentiation/drug effects ; Cell Line ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Neuroblastoma/pathology ; Neurons/*cytology ; Papaverine/antagonists & inhibitors ; Phorbols/*pharmacology ; Prostaglandins E/antagonists & inhibitors ; Tetradecanoylphorbol Acetate/*pharmacology
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    Chick embryonic skin as a rapid organ culture assay for cellular neoplasia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: We used chick embryonic skin (CES) in organ culture to assess the neoplastic potential of a variety of cultured human and nonhuman cell lines. Cells derived from cancer tissues grew in CES and formed tumors in nude mice while cells derived from normal tissues grew in neither system. The CES proved to be more sensitive than the nude mouse when used to assay SV40 transformed human cells; each of four such lines grew in CES while only one of the four lines grew and formed tumors in nude mice. In addition, the patterns of invasion by inoculated cells can be easily studied in the CES. These results suggest that CES in organ culture offers an inexpensive, rapid, and reliable alternative to the nude mouse as a tumorigenicity test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, P D -- Johnson, J B -- O'Donnell, R -- Petricciani, J C -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):980-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Line ; Cell Survival ; *Cell Transformation, Neoplastic ; *Chick Embryo/metabolism ; Mice ; Mice, Nude ; Mitosis ; Neoplasm Invasiveness ; Neoplasms/*metabolism/pathology ; *Organ Culture Techniques ; Simian virus 40 ; Skin/*embryology/metabolism/pathology
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  • 30
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    Histidine transfer RNA levels in Friend leukemia cells: stimulation by histidine deprivation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Friend leukemia cells incubated with sublethal concentrations of histidinol for 5 to 6 days show up to twofold increases in their relative concentrations of histidine transfer RNA and no change in the relative concentrations of leucine transfer RNA. A similar effect is seen when cells are grown to stationary phase in the presence of 0.2 times the amount of histidine in Eagle's minimum essential medium. These observations support the theory that the concentrations of specific transfer RNA's are regulated by a mechanism that is sensitive to the extent of their aminoacylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Litt, M -- Weiser, K -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):527-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/248241" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cell Line ; Histidine/metabolism ; Histidine-tRNA Ligase/antagonists & inhibitors ; Histidinol/pharmacology ; Leucine/metabolism ; RNA, Transfer/*metabolism ; RNA, Transfer, Amino Acyl/*metabolism
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    Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Exogenously added prostaglandins E1 and E2, but not F2alpha, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3',5'-monophosphate (cyclic AMP) in modulating macrophage functional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic AMP consistently inhibits expression of cytotoxicity. Since the activated macrophage releases high concentrations of prostaglandin E2, it is postulated that this prostaglandin could act locally in negative feedback inhibition to limit cell activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schultz, R M -- Pavlidis, N A -- Stylos, W A -- Chirigos, M A -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cytotoxicity, Immunologic/drug effects ; Immunity, Cellular/*drug effects ; Interferons/*antagonists & inhibitors ; Macrophages/*immunology ; Male ; Mice ; Neoplasms, Experimental/*immunology ; Nucleotides, Cyclic/pharmacology ; Prostaglandins E/*pharmacology ; Prostaglandins F/pharmacology
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    L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wick, M M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):775-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622565" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benserazide/pharmacology ; Cell Line ; Drug Synergism ; Leucine/metabolism ; Levodopa/*analogs & derivatives/pharmacology/therapeutic use ; Male ; Mice ; Neoplasms, Experimental/drug therapy/metabolism ; Neuroblastoma/*drug therapy/metabolism ; Thymidine/metabolism ; Uridine/metabolism
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    Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolff, S -- Rodin, B -- New York, N.Y. -- Science. 1978 May 5;200(4341):543-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644315" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Chromatids/*drug effects ; Crossing Over, Genetic/*drug effects ; Dose-Response Relationship, Drug ; HeLa Cells ; Saccharin/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 34
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    Production of antibody to tetanus toxoid by continuous human lymphoblastoid cell lines (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: Peripheral lymphocytes from human volunteers boosted with tetanus toxoid were cultured after in vitro infection with Epstein-Barr virus. Forty-four continuous lymphoblastoid lines were established which continued to secrete human gamma globulin; seven of these secreted antibody to tetanus toxoid. Subcultures derived from limiting dilution experiments continued to secrete the antibody. Some of these antibody-secreting cells have been in continuous culture for more than 6 months.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zurawski, V R Jr -- Haber, E -- Black, P H -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1439-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204013" target="_blank"〉PubMed〈/a〉
    Keywords: Antibody Formation ; Antibody Specificity ; Cell Line ; Clone Cells/immunology ; Herpesvirus 4, Human ; Histological Techniques ; Humans ; Lymphocytes/*immunology ; *Tetanus Antitoxin ; *Tetanus Toxoid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 35
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    Immunofluorescent detection of nuclear double-stranded RNA in situ in Vero and mosquito cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-23
    Description: Double-stranded RNA (dsRNA) was detected in situ by indirect immunofluorescence with antibodies to dsRNA. It was seen in nuclei of Vero and Aedes albopictus cells, but not in BHK cells, KB cells, chick embryo fibroblasts, or HeLa cells. Reactive dsRNA was present in the nucleoplasm, but not in nucleoli or cytoplasm. Extracted RNA from the whole cell contained from 0.08 percent (BHK) to 0.46 percent (HeLa) dsRNA, as estimated by serological methods. This dsRNA, found in molecules having the size distribution of heterogeneous nuclear RNA, did not renature rapidly after denaturation. The quantity of dsRNA in total extracted RNA did not correlate with the presence or absence of nuclear staining in situ.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stollar, B D -- Koo, R -- Stollar, V -- New York, N.Y. -- Science. 1978 Jun 23;200(4348):1381-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26972" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Nucleolus/analysis ; Cell Nucleus/*analysis ; Culicidae ; Cytoplasm/analysis ; Fluorescent Antibody Technique ; Nucleic Acid Conformation ; RNA/*analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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