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  • 1
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    Self-Assembled Molecules – New Kind of Protein Ligands : Supramolecular Ligands (2018)
    Cham : Springer
    Details
    Keywords: Medicine ; Proteins ; Biology ; Technique ; Biomedicine ; Biomedicine general ; Protein Science ; Protein-Ligand Interactions ; Biological Techniques
    Description / Table of Contents: Supramolecular Protein Ligands – Unexplored Teritory Of Potential Pharmacological Activity --- Supramolecular Congo Red As Specific Ligand Of Antibodies Engaged In Immune Complex --- Protein Conditioning For Binding Congo Red And Other Supramolecular Ligands --- Metal Ions Introduced To Proteins By Supramolecular Ligands --- Possible Mechanism Of Amyloidogenesis Of V Domains --- Supramolecular Structures As Carrier Systems Enabling The Use Of Metal Ions In Antibacterial Therapy --- Congo Red Interactions With Single-Walled Carbon Nanotubes
    Pages: Online-Ressource (XII, 136 pages) , 98 illustrations, 44 illustrations in color
    ISBN: 9783319656397
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-65639-7
    Language: English
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  • 2
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    Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018)
    Singapore : Springer
    Details
    Keywords: Medicine ; Neurosciences ; Pharmacology ; Neurology ; Biomedicine ; Neurosciences ; Neurology ; Pharmacology/Toxicology
    Description / Table of Contents: 1.Overview --- 2.In vivo imaging of nicotinic acetylcholine receptors in the central nervous system --- 3.A new aspect of cholinergic transmission in the central nervous system --- 4.Nicotinic acetylcholine receptor signaling: roles in neuroprotection --- 5.Regulation by nicotinic acetylcholine receptors of microglial glutamate transporters: role of microglia in neuroprotection --- 6.Shati/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans --- 7.Nicotinic acetylcholine receptors in regulation of pathology of cerebrovascular disorders --- 8.Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer’s and Parkinson’s diseases --- 9.SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors --- 10.Removal of blood amyloid as a therapeutic strategy for Alzheimer’s disease: the influence of smoking and nicotine
    Pages: Online-Ressource (X, 191 pages) , 62 illustrations, 20 illustrations in color
    ISBN: 9789811084881
    URL: https://link.springer.com/openurl?genre=book&isbn=978-981-10-8488-1
    Language: English
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  • 3
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    Hormones, Metabolism and the Benefits of Exercise (2017)
    Cham : Springer
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    Keywords: Medicine ; Molecular biology ; Health promotion ; Cardiology ; Diabetes ; Endocrinology ; Metabolic diseases ; Biomedicine ; Molecular Medicine ; Health Promotion and Disease Prevention ; Endocrinology ; Cardiology ; Diabetes ; Metabolic Diseases
    Description / Table of Contents: Introduction --- Human brown adipose tissue plasticity: hormonal and environmental manipulation --- The energy sensor AMPK: Adaptations to exercise, nutritional and hormonal signals --- Plasma steroids and cardiorespiratory fitness response to regular exercise --- Sending the signal: Muscle glycogen availability as a regulator of training adaptation --- Optimized engagement of macrophages and satellite cells in the repair and regeneration of exercised muscle --- Skeletal muscle microRNAs: Roles in differentiation, disease and exercise --- Tryptophan-kynurenine metabolites in exercise and mental health --- FNDC5/irisin - their role in the nervous system and as a mediator for beneficial effects of exercise on the brain
    Pages: Online-Ressource (X, 102 pages)
    ISBN: 9783319727905
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-72790-5
    Language: English
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  • 4
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    Genome Editing in Neurosciences (2017)
    Cham : Springer
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    Keywords: Medicine ; Human genetics ; Neurosciences ; Biomedical engineering ; Biomedicine ; Human Genetics ; Neurosciences ; Biomedical Engineering/Biotechnology
    Description / Table of Contents: Introduction --- In vitro modeling of complex neurological diseases --- Aquatic model organisms in neurosciences : the genome editing revolution --- Genome-wide genetic screening in the mammalian CNS --- CRISPR/Cas9-mediated Knockin and Knockout in Zebrafish --- Dissecting the role of synaptic proteins with CRISPR --- Recurrently Breaking Genes in Neural Progenitors: Potential Roles of DNA Breaks in Neuronal Function, Degeneration and Cancer --- Neuroscience research using non-human primate models and genome editing --- Multiscale genome engineering: Genome-wide screens and targeted approaches --- Using Genome Engineering to Understand Huntington’s Disease --- Therapeutic gene editing in muscles and muscle stem cells
    Pages: Online-Ressource (XI, 123 pages) , 16 illustrations in color
    ISBN: 9783319601922
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-60192-2
    Language: English
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  • 5
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    Micro-, Meso- and Macro-Connectomics of the Brain (2016)
    Cham : Springer
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    Keywords: Medicine ; Neurosciences ; Neurology ; Biomedicine ; Neurosciences ; Neurology
    Description / Table of Contents: Parcellations and connectivity patterns in human and macaque cerebral cortex --- Nanoconnectomics --- Inhibitory cell cypes, circuits and receptive fields in mouse visual cortex --- Form meets function in the brain: observing the activity and structure of specific neural connections --- The network for intracortical communication in mouse visual cortex --- The brain in space --- In-vivo connectivity in monkeys --- Connectome networks: from cells to systems --- Intra- and Inter-hemispheric connectivity supporting hemispheric specialization --- Genetics of the connectome and the ENIGMA project
    Pages: Online-Ressource (X, 166 pages) , 32 illustrations, 28 illustrations in color
    ISBN: 9783319277776
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-27777-6
    Language: English
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  • 6
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    Physiology, Psychoacoustics and Cognition in Normal and Impaired Hearing (2016)
    Cham : Springer
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    Keywords: Medicine ; Neurosciences ; Otorhinolaryngology ; Biomedicine ; Neurosciences ; Otorhinolaryngology
    Description / Table of Contents: The International Symposium on Hearing is a prestigious,triennial gathering where world-class scientists present and discuss the most recent advances in the field of human and animal hearing research. The 2015 edition will particularly focus on integrative approaches linking physiological, psychophysical and cognitive aspects of normal and impaired hearing. Like previous editions, the proceedings will contain about 50 chapters ranging from basic to applied research, and of interest to neuroscientists, psychologists, audiologists, engineers, otolaryngologists, and artificial intelligent researchers
    Pages: Online-Ressource (XXIX, 484 pages) , 138 illustrations, 92 illustrations in color
    ISBN: 9783319254746
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-25474-6
    Language: English
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  • 7
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    Stem Cells in Neuroendocrinology (2016)
    Cham : Springer
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    Keywords: Medicine ; Neurosciences ; Endocrinology ; Biomedicine ; Neurosciences ; Endocrinology
    Description / Table of Contents: A brief overview of techniques for modulating neuroendocrine and other neural systems --- Basics of stem cell biology as applied to the brain --- Human pluripotent-derived lineages for repairing hypopituitarism --- Recapitulating hypothalamus and pituitary development using ES/iPS cells --- Regulation of body weight and metabolism by tanycyte-derived neurogenesis in young adult mice --- Genetic dissection of the neuroendocrine and behavioral responses to stressful challenges --- Pituitary stem cells: quest for hidden functions --- Pituitary stem cells during normal physiology and disease --- Epigenetic mechanisms of pituitary cell fate specification --- Advances in stem cells biology: new approaches to understand depression --- Perspective on stem cells in developmental biology, with special reference to neuroendocrine systems.
    Pages: Online-Ressource (XII, 156 pages) , 16 illustrations in color
    ISBN: 9783319416038
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-41603-8
    Language: English
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  • 8
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    A Time for Metabolism and Hormones (2016)
    Cham : Springer
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    Keywords: Medicine ; Human physiology ; Neurosciences ; Endocrinology ; Cell biology ; Biomedicine ; Human Physiology ; Endocrinology ; Cell Biology ; Neurosciences
    Description / Table of Contents: The Epigenetic And Metabolic Language Of the Circadian Clock --- Molecular Architecture of the Circadian Clock in Mammals --- Circadian Mechanisms in Bioenergetics and Cell Metabolism --- Control of metabolism by central and peripheral clocks in Drosophila --- Circadian post-transcriptional control of metabolism --- Redox and Metabolic Oscillations in the Clockwork --- Rev-erbs: Integrating Metabolism Around the Clock --- Control of sleep-wake cycles in Drosophila --- Circadian metabolomics: insights for biology and medicine --- Rhythms within rhythms: the importance of oscillations for glucocorticoid hormones --- The genetics of autism spectrum disorders.
    Pages: Online-Ressource (XIII, 132 pages) , 28 illustrations, 26 illustrations in color
    ISBN: 9783319270692
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-27069-2
    Language: English
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  • 9
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    Micro-, Meso- and Macro-Dynamics of the Brain (2016)
    Cham : Springer
    Details
    Keywords: Medicine ; Neurosciences ; Neurology ; Psychiatry ; Biomedicine ; Neurosciences ; Neurology ; Psychiatry
    Description / Table of Contents: Hippocampal mechanisms for the segmentation of space by goals and boundaries --- Cortical Evolution: Introduction to the Reptilian Cortex --- Flow of information underlying a tactile decision in mice --- The Visual Brain: Computing through Multiscale Complexity --- Grid cells and spatial maps in entorhinal cortex and hippocampus --- The striatum and decision-making based on value --- Decoding the dynamics of conscious perception: The temporal generalization method --- Sleep and synaptic down-selection --- Federating and integrating what we know about the brain at all scales - a challenge for the future. Computer science meets the clinical neurosciences
    Pages: Online-Ressource (XIII, 172 pages) , 33 illustrations, 30 illustrations in color
    ISBN: 9783319288024
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-28802-4
    Language: English
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  • 10
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    Contemporary Bioethics : Islamic Perspective (2015)
    Cham : Springer
    Details
    Keywords: Medicine ; Human genetics ; Ethics ; Medical ethics ; Biomedicine ; Human Genetics ; Theory of Medicine/Bioethics ; Ethics
    Description / Table of Contents: This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s special gifts to human beings, God’s revelation as given to the prophets is the supernatural source of divine guidance through which human communities have been guided at all times through history. The second part of the book concentrates on the objectives of Islamic religious practice – the maqa' sid – which include: Preservation of Faith, Preservation of Life, Preservation of Mind (intellect and reason), Preservation of Progeny (al-nasl) and Preservation of Property. Lastly, the third part of the book discusses selected topical issues, including abortion, assisted reproduction devices, genetics, organ transplantation, brain death and end-of-life aspects. For each topic, the current medical evidence is followed by a detailed discussion of the ethical issues involved
    Pages: Online-Ressource (XV, 267 pages)
    ISBN: 9783319184289
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-18428-9
    Language: English
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  • 11
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    High Density Lipoproteins : From Biological Understanding to Clinical Exploitation (2015)
    Cham : Springer
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    Keywords: Toxicology ; Medicine ; Human physiology ; Immunology ; Cytology ; Pharmacology/Toxicology ; Molecular Medicine ; Human Physiology ; Immunology ; Cell Biology
    Description / Table of Contents: Preface --- Part 1. Physiology of HDL --- Part 2. Pathology of HDL --- Part 3. Possible Indications and Target Mechanisms of HDL Therapy --- Part 4. Treatments for Dyslipidemias and Dysfunction of HDL
    Pages: Online-Ressource (XIII, 694 pages) , 40 illustrations, 37 illustrations in color
    ISBN: 9783319096650
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-09665-0
    Language: English
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  • 12
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    Innovative Medicine : Basic Research and Development (2015)
    Tokyo : Springer
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    Keywords: Medicine ; Immunology ; Molecular biology ; Cell biology ; Biomedicine ; Molecular Medicine ; Immunology ; Cell Biology
    Description / Table of Contents: Part I Basic Research for Innovative Medicine --- 1. Diverting Glycolysis to Combat Oxidative Stress --- 2. Metabolic Regulation by Nuclear Receptors --- 3. Fighting Fire with Fire in Cancer --- 4. Linear Polyubiquitination: a Crucial Regulator of NF-kB Activation --- 5. VCP, a major ATPase in the cells, as a novel drug target for currently incurable disorders --- 6. Roles of E-cadherin in hepatocarcinogenesis --- 7. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors --- 8. Inhibitory immunoreceptors on mast cells in allergy and inflammation --- 9. Doxycycline-inducible Autoimmune Blistering Skin Disease Model --- 10. T-cell Senescence and Autoimmunity --- Part II Translational Research for Innovative Medicine --- 11. IL-6: A new era for the treatment of autoimmune inflammatory diseases --- 12. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies --- 13. Multifaceted translational approach of major mental illness --- 14. Translational research of leptin in lipodystrophy and its related diseases --- 15. Translational research of the activation of the C-type natriuretic peptide (CNP)-guanylyl cyclase-B pathway for skeletal dysplasia --- 16. Clarity and Challenges in Tissue Fibrosis --- 17. TRP Channels: Their Function and Potentiality as Drug Targets --- 18. Autophagic Cell Death and Cancer Chemotherapeutics --- 19. Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis --- 20. RNA activation --- Part III New Technology for Innovative Medicine --- 21. Cardiac Reprogramming for Heart Repair --- 22. Development of a new in vivo optical probe for biological diagnosis and therapy --- 23. Introduction of mesenchymal stem cells for liver surgery (hepatectomy and transplantation) --- 24. Synaptic and axonal plasticity induction in the human cerebral cortex --- 25. TIM-3 is a novel therapeutic target for eradicating acute myelogenous leukemia stem cells --- 26. TGF-beta LAP degradation products, a novel biomarker and promising therapeutic target for liver fibrogenesis --- 27. Cell-based regenerative therapy for liver disease
    Pages: Online-Ressource (IX, 339 pages)
    ISBN: 9784431556510
    URL: https://link.springer.com/openurl?genre=book&isbn=978-4-431-55651-0
    Language: English
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  • 13
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    Self-Reported Population Health: An International Perspective based on EQ-5D (2014)
    Dordrecht : Springer
    Details
    Keywords: Medicine ; Public health ; Medical research ; Quality of life ; Biomedicine ; Biomedicine general ; Public Health ; Quality of Life Research
    Description / Table of Contents: Preface.- Data and Methods.- Population Norms for the EQ-5D --- Cross-Country Analysis of EQ-5D Data --- Socio-demographic Indicators based on EQ-5D --- Annex 1 --- Annex 2
    Pages: Online-Ressource (XV, 196 pages) , 14 illustrations, 9 illustrations in color
    ISBN: 9789400775961
    URL: https://link.springer.com/openurl?genre=book&isbn=978-94-007-7596-1
    Language: English
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  • 14
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    Self-Reported Population Health: An International Perspective based on EQ-5D (2014)
    Dordrecht : Springer
    Details
    Keywords: Medicine ; Public health ; Medical research ; Quality of life ; Biomedicine ; Biomedicine general ; Public Health ; Quality of Life Research
    Description / Table of Contents: Preface.- Data and Methods.- Population Norms for the EQ-5D --- Cross-Country Analysis of EQ-5D Data --- Socio-demographic Indicators based on EQ-5D --- Annex 1 --- Annex 2
    Pages: Online-Ressource (XV, 196 pages) , 14 illustrations, 9 illustrations in color
    ISBN: 9789400775961
    URL: https://link.springer.com/openurl?genre=book&isbn=978-94-007-7596-1
    Language: English
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  • 15
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    Ion Channels (2008)
    Berlin, Heidelberg : Springer
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    Keywords: Biochemistry ; Chemistry, Organic ; Medicine ; Toxicology
    ISBN: 9783540797296
    URL: https://doi.org/10.1007/978-3-540-79729-6
    Language: English
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  • 16
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    Alzheimer's Disease (2008)
    Berlin, Heidelberg : Springer
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    Keywords: Biochemistry ; Chemistry, Organic ; Medicine ; Toxicology
    ISBN: 9783540742296
    URL: https://doi.org/10.1007/978-3-540-74229-6
    Language: English
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